7W3M
 
 | | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD5_USP14 | | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | | Deposit date: | 2021-11-25 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
Nature, 605, 2022
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1FYF
 | | CRYSTAL STRUCTURE OF A TRUNCATED FORM OF THREONYL-TRNA SYNTHETASE COMPLEXED WITH A SERYL ADENYLATE ANALOG | | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, THREONYL-TRNA SYNTHETASE, ZINC ION | | Authors: | Sankaranarayanan, R, Dock-Bregeon, A.C, Moras, D. | | Deposit date: | 2000-09-29 | | Release date: | 2000-12-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Transfer RNA-mediated editing in threonyl-tRNA synthetase. The class II solution to the double discrimination problem.
Cell(Cambridge,Mass.), 103, 2000
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6ZTQ
 | | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | | Deposit date: | 2020-07-20 | | Release date: | 2020-10-21 | | Last modified: | 2020-10-28 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of inhibitor-bound mammalian complex I.
Nat Commun, 11, 2020
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4D5L
 | | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state | | Descriptor: | 18S RRNA 2, 40S RIBOSOMAL PROTEIN ES1, 40S RIBOSOMAL PROTEIN ES10, ... | | Authors: | Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T. | | Deposit date: | 2014-11-05 | | Release date: | 2015-02-04 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires.
Mol.Cell, 57, 2015
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6ZR2
 | | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | | Deposit date: | 2020-07-10 | | Release date: | 2020-10-21 | | Last modified: | 2020-10-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of inhibitor-bound mammalian complex I.
Nat Commun, 11, 2020
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7W3H
 | | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | | Deposit date: | 2021-11-25 | | Release date: | 2022-05-04 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
Nature, 605, 2022
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7W3J
 | | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SC_USP14 | | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | | Deposit date: | 2021-11-25 | | Release date: | 2022-05-04 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
Nature, 605, 2022
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7W39
 | | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | | Deposit date: | 2021-11-25 | | Release date: | 2022-05-04 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
Nature, 605, 2022
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6SB0
 | | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | | Deposit date: | 2019-07-18 | | Release date: | 2019-10-16 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
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5UM6
 | | Crystal Structure of S. pombe Uba1 in a closed conformation | | Descriptor: | 2-(decylamino)ethane-1-thiol, N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine, SULFATE ION, ... | | Authors: | Lv, Z, Yuan, L, Aldana-Masangkay, G, Atkison, J.H, Chen, Y, Olsen, S.K. | | Deposit date: | 2017-01-26 | | Release date: | 2017-06-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.794 Å) | | Cite: | Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
J. Biol. Chem., 292, 2017
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3W31
 | | Structual basis for the recognition of Ubc13 by the Shigella flexneri effector OspI | | Descriptor: | IODIDE ION, ORF169b, Ubiquitin-conjugating enzyme E2 N | | Authors: | Nishide, A, Kim, M, Takagi, K, Sasakawa, C, Mizushima, T. | | Deposit date: | 2012-12-07 | | Release date: | 2013-03-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI.
J.Mol.Biol., 425, 2013
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3GZN
 | | Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 | | Descriptor: | NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... | | Authors: | Sintchak, M.D. | | Deposit date: | 2009-04-07 | | Release date: | 2010-02-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Mol.Cell, 37, 2010
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1B7Y
 | | PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINYL-ADENYLATE | | Descriptor: | ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PROTEIN (PHENYLALANYL-TRNA SYNTHETASE) | | Authors: | Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G. | | Deposit date: | 1999-01-26 | | Release date: | 2000-01-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue.
J.Mol.Biol., 287, 1999
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6BK8
 | | S. cerevisiae spliceosomal post-catalytic P complex | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Lea1, ... | | Authors: | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | Deposit date: | 2017-11-07 | | Release date: | 2018-02-21 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the yeast spliceosomal postcatalytic P complex.
Science, 358, 2017
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3VX7
 | | Crystal structure of Kluyveromyces marxianus Atg7NTD-Atg10 complex | | Descriptor: | E1, E2 | | Authors: | Yamaguchi, M, Matoba, K, Sawada, R, Fujioka, Y, Nakatogawa, H, Yamamoto, H, Kobashigawa, Y, Hoshida, H, Akada, R, Ohsumi, Y, Noda, N.N, Inagaki, F. | | Deposit date: | 2012-09-11 | | Release date: | 2012-11-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.
Nat.Struct.Mol.Biol., 19, 2012
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3VX6
 | | Crystal structure of Kluyveromyces marxianus Atg7NTD | | Descriptor: | E1 | | Authors: | Yamaguchi, M, Matoba, K, Sawada, R, Fujioka, Y, Nakatogawa, H, Yamamoto, H, Kobashigawa, Y, Hoshida, H, Akada, R, Ohsumi, Y, Noda, N.N, Inagaki, F. | | Deposit date: | 2012-09-11 | | Release date: | 2012-11-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.
Nat.Struct.Mol.Biol., 19, 2012
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1B8A
 | | ASPARTYL-TRNA SYNTHETASE | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PROTEIN (ASPARTYL-TRNA SYNTHETASE) | | Authors: | Schmitt, E, Moulinier, L, Thierry, J.-C, Moras, D. | | Deposit date: | 1999-01-27 | | Release date: | 1999-02-02 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation.
EMBO J., 17, 1998
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5C18
 | | p97-delta709-728 in complex with ATP-gamma-S | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Haenzelmann, P, Schindelin, H. | | Deposit date: | 2015-06-13 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.
Structure, 24, 2016
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5C19
 | | p97 variant 2 in the apo state | | Descriptor: | SULFATE ION, Transitional endoplasmic reticulum ATPase | | Authors: | Haenzelmann, P, Schindelin, H. | | Deposit date: | 2015-06-13 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.
Structure, 24, 2016
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5C1B
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5C1A
 | | p97-N750D/R753D/M757D/Q760D in complex with ATP-gamma-S | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Haenzelmann, P, Schindelin, H. | | Deposit date: | 2015-06-13 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.
Structure, 24, 2016
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6TGV
 | | Crystal structure of Mycobacterium smegmatis CoaBC in complex with CTP and FMN | | Descriptor: | 1,2-ETHANEDIOL, CYTIDINE-5'-TRIPHOSPHATE, Coenzyme A biosynthesis bifunctional protein CoaBC, ... | | Authors: | Mendes, V, Blaszczyk, M, Bryant, O, Cory-Wright, J, Blundell, T.L. | | Deposit date: | 2019-11-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Nat Commun, 12, 2021
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6P59
 | | Crystal structure of SIVrcm Vif-CBFbeta-ELOB-ELOC complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Core-binding factor subunit beta, Elongin-B, ... | | Authors: | Binning, J.M, Chesarino, N.M, Emerman, M, Gross, J.D. | | Deposit date: | 2019-05-29 | | Release date: | 2019-12-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.942214 Å) | | Cite: | Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Cell Host Microbe, 26, 2019
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1EUY
 | | GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH A TRNA MUTANT AND AN ACTIVE SITE INHIBITOR | | Descriptor: | 5'-O-[N-(L-GLUTAMINYL)-SULFAMOYL]ADENOSINE, GLUTAMINYL TRNA, GLUTAMINYL-TRNA SYNTHETASE | | Authors: | Sherlin, L.D, Bullock, T.L, Newberry, K.J, Lipman, R.S.A, Hou, Y.-M, Beijer, B, Sproat, B.S, Perona, J.J. | | Deposit date: | 2000-04-19 | | Release date: | 2000-06-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Influence of transfer RNA tertiary structure on aminoacylation efficiency by glutaminyl and cysteinyl-tRNA synthetases.
J.Mol.Biol., 299, 2000
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8P03
 | | 48S late-stage initiation complex with m6A mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | | Deposit date: | 2023-05-09 | | Release date: | 2024-03-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
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