4I2B
| Ternary complex of mouse TdT with ssDNA and AMPcPP | Descriptor: | 5'-D(P*AP*AP*AP*AP*A)-3', DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA nucleotidylexotransferase, ... | Authors: | Gouge, J, Delarue, M. | Deposit date: | 2012-11-21 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
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8SF7
| 48-nm doublet microtubule from Tetrahymena thermophila strain MEC17 | Descriptor: | CFAM166A, CFAM166B, CFAM166C, ... | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | Deposit date: | 2023-04-10 | Release date: | 2024-05-22 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Effect of alpha-tubulin acetylation on the doublet microtubule structure. Elife, 12, 2024
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9F1B
| Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Yudin, D, Scaiola, A, Ban, N. | Deposit date: | 2024-04-18 | Release date: | 2024-08-21 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | NAC guides a ribosomal multienzyme complex for nascent protein processing. Nature, 633, 2024
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9F1C
| Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Yudin, D, Scaiola, A, Ban, N. | Deposit date: | 2024-04-18 | Release date: | 2024-08-21 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | NAC guides a ribosomal multienzyme complex for nascent protein processing. Nature, 633, 2024
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9F1D
| Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Yudin, D, Scaiola, A, Ban, N. | Deposit date: | 2024-04-18 | Release date: | 2024-08-21 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | NAC guides a ribosomal multienzyme complex for nascent protein processing. Nature, 633, 2024
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8G3D
| 48-nm doublet microtubule from Tetrahymena thermophila strain K40R | Descriptor: | B2B3_fMIP, B5B6_fMIP, CFAM166A, ... | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | Deposit date: | 2023-02-07 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins. Nat Commun, 14, 2023
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8G2Z
| 48-nm doublet microtubule from Tetrahymena thermophila strain CU428 | Descriptor: | B2B3_fMIP, B5B6_fMIP, CFAM166A, ... | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | Deposit date: | 2023-02-06 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins. Nat Commun, 14, 2023
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8OKF
| WD repeat containing protein 5 (WDR5)- PER2 peptide | Descriptor: | CHLORIDE ION, Glutathione S-transferase class-mu 26 kDa isozyme,WD repeat domain 5, PENTAETHYLENE GLYCOL, ... | Authors: | Wolf, E, Boergel, A. | Deposit date: | 2023-03-28 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A structural competition involving WDR5 times circadian oscillations To Be Published
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8OK1
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8DHB
| Active FLCN GAP complex | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ... | Authors: | Jansen, R.M, Hurley, J.H. | Deposit date: | 2022-06-25 | Release date: | 2022-09-28 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation. Sci Adv, 8, 2022
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5LNC
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8WA3
| Cryo-EM structure of peptide free and Gs-coupled GIPR | Descriptor: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | Deposit date: | 2023-09-06 | Release date: | 2024-03-06 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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8FON
| Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Nguyen, H.A, Hoffer, E.D, Maehigashi, T, Fagan, C.E, Dunham, C.M. | Deposit date: | 2023-01-02 | Release date: | 2023-03-29 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.64 Å) | Cite: | Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches. J.Biol.Chem., 299, 2023
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8FOM
| Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Nguyen, H.A, Hoffer, E.D, Maehigashi, T, Fagan, C.E, Dunham, C.M. | Deposit date: | 2023-01-02 | Release date: | 2023-03-29 | Last modified: | 2023-04-26 | Method: | X-RAY DIFFRACTION (3.58 Å) | Cite: | Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches. J.Biol.Chem., 299, 2023
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3EZR
| CDK-2 with indazole inhibitor 17 bound at its active site | Descriptor: | 3-methoxy-4-{3-[4-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2 | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | Deposit date: | 2008-10-23 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor Bioorg.Med.Chem.Lett., 19, 2009
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3F5X
| CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site | Descriptor: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2, Cyclin-A2, ... | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | Deposit date: | 2008-11-04 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg.Med.Chem.Lett., 19, 2009
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3EZV
| CDK-2 with indazole inhibitor 9 bound at its active site | Descriptor: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2 | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | Deposit date: | 2008-10-23 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor Bioorg.Med.Chem.Lett., 19, 2009
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8G5Z
| mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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8G60
| mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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8G5Y
| mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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8GLP
| mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-03-22 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.67 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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8QOI
| Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA | Descriptor: | 18S rRNA (1740-MER), 28S rRNA (3773-MER), 40S ribosomal protein S10, ... | Authors: | Holvec, S, Barchet, C, Frechin, L, Hazemann, I, von Loeffelholz, O, Klaholz, B.P. | Deposit date: | 2023-09-29 | Release date: | 2024-06-12 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | The structure of the human 80S ribosome at 1.9 angstrom resolution reveals the molecular role of chemical modifications and ions in RNA. Nat.Struct.Mol.Biol., 31, 2024
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8P2K
| Ternary complex of translating ribosome, NAC and METAP1 | Descriptor: | 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N. | Deposit date: | 2023-05-16 | Release date: | 2023-07-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | NAC controls cotranslational N-terminal methionine excision in eukaryotes. Science, 380, 2023
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8SNB
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7QVP
| Human collided disome (di-ribosome) stalled on XBP1 mRNA | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Denk, T.G, Tesina, P, Beckmann, R. | Deposit date: | 2022-01-22 | Release date: | 2022-10-12 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat Commun, 13, 2022
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