PDB: 5631 resultsInfo pagesStatus searchChemie searchBIRD

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8CCR	Crystal structure of the T19D mutant of the de novo diheme binding 4D2 Descriptor: (2S)-2-hydroxybutanedioic acid, 4D2 (mutant T19D), CHLORIDE ION, ... Authors: Barringer, R, Anderson, R. Deposit date: 2023-01-27 Release date: 2023-08-09 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.1 Å) Cite: An expandable, modular de novo protein platform for precision redox engineering. Proc.Natl.Acad.Sci.USA, 120, 2023
5EZE	A de novo designed heptameric coiled coil CC-Hept-I18betaMeCys-L22H-I25E Descriptor: CC-Hept-bMeCys-His-Glu, GLYCEROL Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZ9	A de novo designed heptameric coiled coil CC-Hept-I-H-I Descriptor: CC-Hept-L22H, HEXANE-1,6-DIOL Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5F2Y	A de novo designed heptameric coiled coil CC-Hept-homoCys-H-E Descriptor: CC-Hept-hCys-H-E Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-12-02 Release date: 2016-07-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZ8	A de novo designed heptameric coiled coil CC-Hept-I-C-I Descriptor: CC-Hept-I-C-I Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZA	A de novo designed heptameric coiled coil CC-Hept-I18C-L22H Descriptor: CC-Hept-C-H-I, GLYCEROL Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
5EZC	A de novo designed heptameric coiled coil CC-Hept-I18C-L22H-I25E Descriptor: CC-Hept-C-H-E Authors: Burton, A.J, Brady, R.L, Woolfson, D.N. Deposit date: 2015-11-26 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Installing hydrolytic activity into a completely de novo protein framework. Nat.Chem., 8, 2016
6LLQ	Solution NMR structure of de novo Rossmann2x2 fold with most of the core mutated to valine, R2x2_VAL88 Descriptor: VAL88 Authors: Kobayashi, N, Sugiki, T, Fujiwara, T, Koga, R, Yamamoto, M, Kosugi, T, Koga, N. Deposit date: 2019-12-23 Release date: 2020-12-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Robust folding of a de novo designed ideal protein even with most of the core mutated to valine. Proc.Natl.Acad.Sci.USA, 117, 2020
5EON	Crystal structure of a de novo antiparallel coiled-coil hexamer - ACC-Hex Descriptor: ACC-Hex Authors: Spencer, R.K, Hochbaum, A.I. Deposit date: 2015-11-10 Release date: 2016-05-25 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.696 Å) Cite: X-ray Crystallographic Structure and Solution Behavior of an Antiparallel Coiled-Coil Hexamer Formed by de Novo Peptides. Biochemistry, 55, 2016
6W70	Crystal Structure of apixaban-bound ABLE Descriptor: 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ACETATE ION, De novo designed ABLE, ... Authors: Polizzi, N.F. Deposit date: 2020-03-18 Release date: 2020-08-26 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.296 Å) Cite: A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
6W6X	Crystal Structure of ABLE Apo-protein Descriptor: ACETATE ION, De novo designed ABLE protein, SULFATE ION Authors: Polizzi, N.F. Deposit date: 2020-03-18 Release date: 2020-08-26 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.297 Å) Cite: A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
5EHB	A de novo designed hexameric coiled-coil peptide with iodotyrosine Descriptor: pHiosYI Authors: Lizatovic, R, Aurelius, O, Stenstrom, O, Drakenberg, T, Akke, M, Logan, D.T, Andre, I. Deposit date: 2015-10-28 Release date: 2016-06-15 Last modified: 2018-01-17 Method: X-RAY DIFFRACTION (3.19 Å) Cite: A De Novo Designed Coiled-Coil Peptide with a Reversible pH-Induced Oligomerization Switch. Structure, 24, 2016
6Z0L	Het-N2 - De novo designed three-helix heterodimer with Cysteine at the N2 position of the alpha-helix Descriptor: CADMIUM ION, Cys-N2 Strand, Positive Strand, ... Authors: McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. Deposit date: 2020-05-09 Release date: 2021-03-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
6Z0M	Het-Ncap - De novo designed three-helix heterodimer with Cysteine at the Ncap position of the alpha-helix Descriptor: Cys-Ncap strand, Positive Strand, SULFATE ION, ... Authors: McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. Deposit date: 2020-05-09 Release date: 2021-03-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
5JI4	Solution structure of the de novo mini protein gEEHE_02 Descriptor: W37 Authors: Buchko, G.W, Bahl, C.D, Pulavarti, S.V, Baker, D, Szyperski, T. Deposit date: 2016-04-21 Release date: 2016-09-28 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Accurate de novo design of hyperstable constrained peptides. Nature, 538, 2016
7BEY	Het-N2-SO3- - De novo designed three-helix heterodimer with Cysteine S-sulfate at the N2 position of the alpha-helix Descriptor: 'Cys-N2-SO3-' Strand, 'Positive' Strand, SULFATE ION Authors: McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. Deposit date: 2021-01-06 Release date: 2021-03-17 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
7BIM	A de novo designed nonameric coiled coil, CC-Type2-(GgLaId)4 Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Nonameric de novo coiled coil CC-Type2-(GgLaId)4 Authors: Shelley, K.L, Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. Deposit date: 2021-01-12 Release date: 2021-04-21 Last modified: 2021-11-17 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
8UGC	FD15: Flat repeat helix-turn-helix-turn protein Descriptor: FD15 Authors: Davila-Hernandez, F, Bera, A.K, Kang, A, Baker, D. Deposit date: 2023-10-05 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (4 Å) Cite: Directing polymorph specific calcium carbonate formation with de novo protein templates. Nat Commun, 14, 2023
5JHI	Solution structure of the de novo mini protein gEHE_06 Descriptor: W35 Authors: Buchko, G.W, Bahl, C.D, Gilmore, J.M, Pulavarti, S.V, Baker, D, Szyperski, T. Deposit date: 2016-04-21 Release date: 2016-09-28 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Accurate de novo design of hyperstable constrained peptides. Nature, 538, 2016
7OSU	sTIM11noCys-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 1) Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Romero-Romero, S, Kordes, S, Hocker, B. Deposit date: 2021-06-09 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels. Protein Sci., 31, 2022
7OT7	sTIM11noCys-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 2) Descriptor: sTIM11noCys-SB Authors: Romero-Romero, S, Kordes, S, Hocker, B. Deposit date: 2021-06-09 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.51 Å) Cite: A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels. Protein Sci., 31, 2022
3VJF	Crystal structure of de novo 4-helix bundle protein WA20 Descriptor: POTASSIUM ION, WA20 Authors: Arai, R, Kimura, A, Kobayashi, N, Matsuo, K, Sato, T, Wang, A.F, Platt, J.M, Bradley, L.H, Hecht, M.H. Deposit date: 2011-10-18 Release date: 2012-03-28 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Domain-swapped dimeric structure of a stable and functional de novo four-helix bundle protein, WA20 J.Phys.Chem.B, 116, 2012
3P6I	Crystal structure of Symfoil-4T Permutation #2: de novo designed beta-trefoil architecture with symmetric primary structure Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, de novo designed beta-trefoil architecture with symmetric primary structure Authors: Blaber, M, Lee, J. Deposit date: 2010-10-11 Release date: 2011-10-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Permutations study of de novo designed symmetric beta-trefoil architecture To be Published
7AH0	Crystal structure of the de novo designed two-heme binding protein, 4D2 Descriptor: 4D2, PROTOPORPHYRIN IX CONTAINING FE Authors: Hutchins, G.H, Parnell, A.E, Anderson, J.L.R. Deposit date: 2020-09-23 Release date: 2021-10-06 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.91 Å) Cite: An expandable, modular de novo protein platform for precision redox engineering. Proc.Natl.Acad.Sci.USA, 120, 2023
3RA3	Crystal structure of a section of a de novo design gigaDalton protein fibre Descriptor: SODIUM ION, p1c, p2f Authors: Zaccai, N.R, Sharp, T.H, Bruning, M, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-27 Release date: 2012-08-08 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design Proc.Natl.Acad.Sci.USA, 109, 2012

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