7KIZ
 
 | | reduced human peroxiredoxin 2 | | Descriptor: | Peroxiredoxin-2 | | Authors: | Kean, K.M, Karplus, P.A. | | Deposit date: | 2020-10-25 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.
J.Biol.Chem., 296, 2021
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7KJ1
 | | human peroxiredoxin 2 - C172S mutant | | Descriptor: | Peroxiredoxin-2 | | Authors: | Kean, K.M, Karplus, P.A. | | Deposit date: | 2020-10-25 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.
J.Biol.Chem., 296, 2021
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1E2Y
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1ZME
 | | CRYSTAL STRUCTURE OF PUT3/DNA COMPLEX | | Descriptor: | DNA (5'-D(*AP*CP*GP*GP*AP*GP*(5IU)P*TP*GP*GP*CP*TP*(5IU)P*CP*CP*CP*G)-3'), DNA (5'-D(*AP*CP*GP*GP*GP*AP*AP*GP*CP*CP*AP*AP*CP*TP*CP*CP*G)-3'), PROLINE UTILIZATION TRANSCRIPTION ACTIVATOR, ... | | Authors: | Swaminathan, K, Marmorstein, R. | | Deposit date: | 1997-08-06 | | Release date: | 1998-09-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a PUT3-DNA complex reveals a novel mechanism for DNA recognition by a protein containing a Zn2Cys6 binuclear cluster.
Nat.Struct.Biol., 4, 1997
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8ZTP
 | | Crystal structure of cysteine desulfurase Sufs from Mycoplasma Pneumonia | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, cysteine desulfurase | | Authors: | Wang, W.M, Ma, D.Y, Gong, W.J, Yao, H, Liu, Y.H, Wang, H.F. | | Deposit date: | 2024-06-07 | | Release date: | 2024-12-11 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The reduced interaction between SufS and SufU in Mycoplasma penetrans results in diminished sulfotransferase activity.
Int.J.Biol.Macromol., 284, 2024
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1DM3
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2MFS
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1R1R
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4MLW
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3PNI
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1DKI
 | | CRYSTAL STRUCTURE OF THE ZYMOGEN FORM OF STREPTOCOCCAL PYROGENIC EXOTOXIN B ACTIVE SITE (C47S) MUTANT | | Descriptor: | PYROGENIC EXOTOXIN B ZYMOGEN, SULFATE ION | | Authors: | Kagawa, T.F, Cooney, J.C, Baker, H.M, McSweeney, S, Liu, M, Gubba, S, Musser, J.M, Baker, E.N. | | Deposit date: | 1999-12-07 | | Release date: | 2000-03-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
Proc.Natl.Acad.Sci.USA, 97, 2000
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5UAO
 | | Crystal structure of MibH, a lathipeptide tryptophan 5-halogenase | | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Tryptophane-5-halogenase | | Authors: | Cogan, D.P, Nair, S.K. | | Deposit date: | 2016-12-19 | | Release date: | 2017-01-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.
ACS Chem. Biol., 12, 2017
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2HT9
 | | The structure of dimeric human glutaredoxin 2 | | Descriptor: | 12-mer peptide, FE2/S2 (INORGANIC) CLUSTER, GLUTATHIONE, ... | | Authors: | Johansson, C, Smee, C, Kavanagh, K.L, Debreczeni, J, von Delft, F, Gileadi, O, Arrowsmith, C, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-07-25 | | Release date: | 2006-08-29 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria
J.Biol.Chem., 282, 2007
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2K7G
 | | Solution Structure of varv F | | Descriptor: | Varv peptide F | | Authors: | Wang, C.K. | | Deposit date: | 2008-08-10 | | Release date: | 2009-02-10 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold
J.Biol.Chem., 284, 2009
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2PNO
 | | Crystal structure of human leukotriene C4 synthase | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, Leukotriene C4 synthase | | Authors: | Ago, H, Kanaoka, Y, Irikura, D, Lam, B.K, Shimamura, T, Austen, K.F, Miyano, M. | | Deposit date: | 2007-04-24 | | Release date: | 2007-08-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
Nature, 448, 2007
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1M4U
 | | Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein-7, Noggin | | Authors: | Groppe, J, Greenwald, J, Wiater, E, Rodriguez-Leon, J, Economides, A.N, Kwiatkowski, W, Affolter, M, Vale, W.W, Izpisua-Belmonte, J.C, Choe, S. | | Deposit date: | 2002-07-03 | | Release date: | 2002-12-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin
Nature, 420, 2002
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1N7J
 | | The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor | | Descriptor: | 7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | McMillan, F.M, Archbold, J, McLeish, M.J, Caine, J.M, Criscione, K.R, Grunewald, G.L, Martin, J.L. | | Deposit date: | 2002-11-15 | | Release date: | 2003-12-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
J.Med.Chem., 47, 2004
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1N7I
 | | The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046 | | Descriptor: | 8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | McMillan, F.M, Archbold, J, McLeish, M.J, Caine, J.M, Criscione, K.R, Grunewald, G.L, Martin, J.L. | | Deposit date: | 2002-11-15 | | Release date: | 2003-12-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
J.Med.Chem., 47, 2004
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2AN4
 | | Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine | | Descriptor: | 4-(2R-AMINO-1-HYDROXYETHYL)PHENOL, PHOSPHATE ION, Phenylethanolamine N-methyltransferase, ... | | Authors: | Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L. | | Deposit date: | 2005-08-11 | | Release date: | 2006-03-14 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
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2AN5
 | | Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor, trans-(1S,2S)-2-amino-1-tetralol | | Descriptor: | PHOSPHATE ION, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L. | | Deposit date: | 2005-08-11 | | Release date: | 2006-03-14 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
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2AN3
 | | Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate cis-(1R,2S)-2-amino-1-tetralol. | | Descriptor: | CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L. | | Deposit date: | 2005-08-11 | | Release date: | 2006-03-14 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
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1N1U
 | | NMR structure of [Ala1,15]kalata B1 | | Descriptor: | kalata B1 | | Authors: | Daly, N.L, Clark, R.J, Craik, D.J. | | Deposit date: | 2002-10-20 | | Release date: | 2003-02-25 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Disulfide Folding Pathways of Cystine Knot Proteins. TYING THE KNOT WITHIN THE CIRCULAR BACKBONE OF THE CYCLOTIDES
J.Biol.Chem., 278, 2003
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1IY6
 | | Solution structure of OMSVP3 variant, P14C/N39C | | Descriptor: | OMSVP3 | | Authors: | Hemmi, H, Kumazaki, T, Yamazaki, T, Kojima, S, Yoshida, T, Kyogoku, Y, Katsu, M, Yokosawa, H, Miura, K, Kobayashi, Y. | | Deposit date: | 2002-07-23 | | Release date: | 2003-03-11 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Inhibitory Specificity Change of Ovomucoid Third Domain of the Silver Pheasant upon Introduction of an Engineered Cys14-Cys39 Bond
BIOCHEMISTRY, 42, 2003
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1IY5
 | | Solution structure of wild type OMSVP3 | | Descriptor: | OMSVP3 | | Authors: | Hemmi, H, Kumazaki, T, Yamazaki, T, Kojima, S, Yoshida, T, Kyogoku, Y, Katsu, M, Yokosawa, H, Miura, K, Kobayashi, Y. | | Deposit date: | 2002-07-23 | | Release date: | 2003-03-11 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Inhibitory Specificity Change of Ovomucoid Third Domain of the Silver Pheasant upon Introduction of an Engineered Cys14-Cys39 Bond
BIOCHEMISTRY, 42, 2003
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3CIU
 | | Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic | | Descriptor: | 5-(2,5-dioxopyrrolidin-1-yl)-N-[2-(2-{2-[(4-O-alpha-D-idopyranosyl-alpha-D-mannopyranosyl)oxy]ethoxy}ethoxy)ethyl]pentanamide, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | | Authors: | Bhatt, V.S, Zhang, Y, Sun, G, Wang, P.G, Palmer, A.F. | | Deposit date: | 2008-03-11 | | Release date: | 2008-04-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic
To be Published
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