4DS6
 
 | | Crystal structure of a group II intron in the pre-catalytic state | | Descriptor: | MAGNESIUM ION, Mutant Group IIC Intron | | Authors: | Chan, R.T, Robart, A.R, Rajashankar, K.R, Pyle, A.M, Toor, N. | | Deposit date: | 2012-02-17 | | Release date: | 2012-04-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.644 Å) | | Cite: | Crystal structure of a group II intron in the pre-catalytic state.
Nat.Struct.Mol.Biol., 19, 2012
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5ES3
 | | Co-crystal structure of LDH liganded with oxamate | | Descriptor: | L-lactate dehydrogenase A chain, OXAMIC ACID | | Authors: | Nowicki, M.W, Wear, M.A, McNae, I.W, Blackburn, E.A. | | Deposit date: | 2015-11-16 | | Release date: | 2016-01-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using AKTAxpressTM.
Plos One, 10, 2015
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6WJS
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3BPN
 | | Crystal structure of the IL4-IL4R-IL13Ra ternary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13 receptor alpha-1 chain, Interleukin-4, ... | | Authors: | Garcia, K.C. | | Deposit date: | 2007-12-18 | | Release date: | 2008-02-05 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
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4H62
 | | Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, ... | | Authors: | Lariviere, L, Plaschka, C, Seizl, M, Wenzeck, L, Kurth, F, Cramer, P. | | Deposit date: | 2012-09-19 | | Release date: | 2012-10-31 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the Mediator head module.
Nature, 492, 2012
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5OCT
 | | Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, GTPase KRas, ... | | Authors: | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | | Deposit date: | 2017-07-03 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
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3BPL
 | | Crystal structure of the IL4-IL4R-Common Gamma ternary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Garcia, K.C. | | Deposit date: | 2007-12-18 | | Release date: | 2008-02-05 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
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1AYN
 | | HUMAN RHINOVIRUS 16 COAT PROTEIN | | Descriptor: | HUMAN RHINOVIRUS 16 COAT PROTEIN, LAURIC ACID, MYRISTIC ACID, ... | | Authors: | Hadfield, A.T, Oliveira, M.A, Zhao, R, Rossmann, M.G. | | Deposit date: | 1997-11-06 | | Release date: | 1998-01-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The structure of human rhinovirus 16.
Structure, 1, 1993
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1CKP
 | | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B | | Descriptor: | 1,2-ETHANEDIOL, PROTEIN (CYCLIN-DEPENDENT PROTEIN KINASE 2), PURVALANOL B | | Authors: | Gray, N.S, Thunnissen, A.M.W.H, Schultz, P.G, Kim, S.H. | | Deposit date: | 1998-07-14 | | Release date: | 1999-01-13 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science, 281, 1998
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4V0U
 | | The crystal structure of ternary PP1G-PPP1R15B and G-actin complex | | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | | Deposit date: | 2014-09-18 | | Release date: | 2015-03-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (7.88 Å) | | Cite: | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
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1GIT
 | | STRUCTURE OF GTP-BINDING PROTEIN | | Descriptor: | G PROTEIN GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION | | Authors: | Berghuis, A.M, Lee, E, Sprang, S.R. | | Deposit date: | 1996-10-16 | | Release date: | 1997-02-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.
Structure, 4, 1996
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5D6Y
 | | Crystal structure of double tudor domain of human lysine demethylase KDM4A complexed with histone H3K23me3 | | Descriptor: | Lysine-specific demethylase 4A, peptide H3K23me3 (19-28) | | Authors: | Wang, F, Su, Z, Miller, M.D, Denu, J.M, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2015-08-13 | | Release date: | 2016-02-10 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.287 Å) | | Cite: | Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
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2E3U
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5NVB
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6CHR
 | | Crystal structure of a group II intron lariat with an intact 3' splice site (pre-2s state) | | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*UP*GP*UP*UP*UP*AP*UP*UP*AP*AP*AP*AP*A)-3'), RNA (621-MER), ... | | Authors: | Chan, R.T, Peters, J.K, Robart, A.R, Wiryaman, T, Rajashankar, K.R, Toor, N. | | Deposit date: | 2018-02-22 | | Release date: | 2018-11-21 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Structural basis for the second step of group II intron splicing.
Nat Commun, 9, 2018
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1CGM
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5N5B
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2H6M
 | | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | | Descriptor: | N-ACETYL-LEUCYL-ALANYL-ALANYL-(N,N-DIMETHYL)-GLUTAMINE-(1,4-DIOXO-3,4-DIHYDRO-1H-PHTHALAZIN-2-YL)METHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Picornain 3C | | Authors: | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | | Deposit date: | 2006-05-31 | | Release date: | 2006-08-08 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
J.Mol.Biol., 361, 2006
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1QBJ
 | | CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX | | Descriptor: | DNA (5'-D(*TP*CP*GP*CP*GP*CP*G)-3'), PROTEIN (DOUBLE-STRANDED RNA SPECIFIC ADENOSINE DEAMINASE (ADAR1)) | | Authors: | Schwartz, T, Rould, M.A, Rich, A. | | Deposit date: | 1999-04-22 | | Release date: | 1999-07-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.
Science, 284, 1999
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4FME
 | | EspG-Rab1-Arf6 complex | | Descriptor: | ADP-ribosylation factor 6, ALUMINUM FLUORIDE, EspG protein, ... | | Authors: | Shao, F, Zhu, Y. | | Deposit date: | 2012-06-16 | | Release date: | 2012-09-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses.
Cell(Cambridge,Mass.), 150, 2012
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4FMB
 | | VirA-Rab1 complex structure | | Descriptor: | ALUMINUM FLUORIDE, Cysteine protease-like virA, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Shao, F, Zhu, Y. | | Deposit date: | 2012-06-16 | | Release date: | 2012-09-05 | | Last modified: | 2012-10-03 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses.
Cell(Cambridge,Mass.), 150, 2012
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1ZM5
 | | Conjugative Relaxase TRWC in complex with ORIT dna, cooper-bound structure | | Descriptor: | COPPER (II) ION, DNA (25-MER), SULFATE ION, ... | | Authors: | Boer, R, Russi, S, Guasch, A, Lucas, M, Blanco, A.G, Coll, M, de la Cruz, F. | | Deposit date: | 2005-05-10 | | Release date: | 2006-04-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Unveiling the Molecular Mechanism of a Conjugative Relaxase: The Structure of TrwC Complexed with a 27-mer DNA Comprising the Recognition Hairpin and the Cleavage Site
J.Mol.Biol., 358, 2006
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1Y5R
 | | The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone | | Descriptor: | CORTICOSTERONE, Corticosteroid 11-beta-dehydrogenase, isozyme 1, ... | | Authors: | Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S. | | Deposit date: | 2004-12-02 | | Release date: | 2005-05-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
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1Y5M
 | | The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes | | Descriptor: | Corticosteroid 11-beta-dehydrogenase, isozyme 1, N-OCTANE, ... | | Authors: | Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S.R. | | Deposit date: | 2004-12-02 | | Release date: | 2005-05-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
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1TJL
 | | Crystal structure of transcription factor DksA from E. coli | | Descriptor: | DnaK suppressor protein, ZINC ION | | Authors: | Perederina, A, Svetlov, V, Vassylyeva, M.N, Artsimovitch, I, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-06-06 | | Release date: | 2004-09-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription
Cell(Cambridge,Mass.), 118, 2004
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