5OCT
Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.
Summary for 5OCT
Entry DOI | 10.2210/pdb5oct/pdb |
Descriptor | GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, [(2~{R})-6-chloranyl-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine, ... (7 entities in total) |
Functional Keywords | domain antibodies, small molecules, drug fragment screening, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 134248.95 |
Authors | Cruz-Migoni, A.,Ehebauer, M.T.,Phillips, S.E.V.,Quevedo, C.E.,Rabbitts, T.H. (deposition date: 2017-07-03, release date: 2018-08-22, Last modification date: 2024-01-17) |
Primary citation | Quevedo, C.E.,Cruz-Migoni, A.,Bery, N.,Miller, A.,Tanaka, T.,Petch, D.,Bataille, C.J.R.,Lee, L.Y.W.,Fallon, P.S.,Tulmin, H.,Ehebauer, M.T.,Fernandez-Fuentes, N.,Russell, A.J.,Carr, S.B.,Phillips, S.E.V.,Rabbitts, T.H. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9:3169-3169, 2018 Cited by PubMed: 30093669DOI: 10.1038/s41467-018-05707-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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