7S1Z
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![BU of 7s1z by Molmil](/molmil-images/mine/7s1z) | Cryo-EM structure of Human NKCC1 K289NA492EL671C | Descriptor: | Solute carrier family 12 member 2 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2021-09-02 | Release date: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13, 2022
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7S1Y
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8FEC
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![BU of 8fec by Molmil](/molmil-images/mine/8fec) | Structure of J-PKAc chimera complexed with Aplithianine derivative | Descriptor: | 6-[(6P)-6-(4-bromo-1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7H-purine, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | Authors: | Du, L, Wilson, B.A.P, Li, N, Martinez Fiesco, J.A, Dalilian, M, Wang, D, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. | Deposit date: | 2022-12-06 | Release date: | 2023-10-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86, 2023
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8FE2
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![BU of 8fe2 by Molmil](/molmil-images/mine/8fe2) | Structure of J-PKAc chimera complexed with Aplithianine A | Descriptor: | 6-[(6M)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-9H-purine, DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha, ... | Authors: | Du, L, Wilson, B.A.P, Li, N, Dalilian, M, Wang, D, Martinez Fiesco, J.A, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. | Deposit date: | 2022-12-05 | Release date: | 2023-10-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86, 2023
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8FE5
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![BU of 8fe5 by Molmil](/molmil-images/mine/8fe5) | Structure of J-PKAc chimera complexed with Aplithianine B | Descriptor: | 6-[(6P)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7,9-dihydro-8H-purin-8-one, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | Authors: | Du, L, Wilson, B.A.P, Li, N, Martinez Fiesco, J.A, Dalilian, M, Wang, D, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. | Deposit date: | 2022-12-05 | Release date: | 2023-10-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86, 2023
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8RKI
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![BU of 8rki by Molmil](/molmil-images/mine/8rki) | Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament fragment | Descriptor: | Choriogenin H, YTTERBIUM (III) ION, Zona pellucida sperm-binding protein 3, ... | Authors: | Wiseman, B, Zamora-Caballero, S, de Sanctis, D, Yasumasu, S, Jovine, L. | Deposit date: | 2023-12-25 | Release date: | 2024-03-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell, 187, 2024
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8EYM
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![BU of 8eym by Molmil](/molmil-images/mine/8eym) | CRYSTAL STRUCTURE OF NAGB-II PHOSPHOSUGAR ISOMERASE FROM SHEWANELLA DENITRIFICANS OS217 IN COMPLEX WITH GLUCITOLAMINE-6-PHOSPHATE AND N-ACETYLGLUCOSAMINE-6-PHOSPHATE AT 2.31 A RESOLUTION | Descriptor: | 2-DEOXY-2-AMINO GLUCITOL-6-PHOSPHATE, 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, GLUCOSAMINE-6-PHOSPHATE DEAMINASE | Authors: | Rodriguez-Hernandez, A, Marcos-Viquez, J, Rodriguez-Romero, A, Bustos-Jaimes, I. | Deposit date: | 2022-10-27 | Release date: | 2023-05-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.311 Å) | Cite: | Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases. Protein Sci., 32, 2023
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7AOI
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![BU of 7aoi by Molmil](/molmil-images/mine/7aoi) | Trypanosoma brucei mitochondrial ribosome large subunit assembly intermediate | Descriptor: | 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L17, ... | Authors: | Tobiasson, V, Gahura, O, Aibara, S, Baradaran, R, Zikova, A, Amunts, A. | Deposit date: | 2020-10-14 | Release date: | 2020-12-02 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit. Embo J., 40, 2021
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7AM2
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![BU of 7am2 by Molmil](/molmil-images/mine/7am2) | Intermediate assembly of the Large subunit from Leishmania major mitochondrial ribosome | Descriptor: | 50S ribosomal protein L13-like protein, ADENOSINE-5'-TRIPHOSPHATE, Acyl carrier protein, ... | Authors: | Soufari, H, Waltz, F, Parrot, C, Bochler, A, Hashem, Y. | Deposit date: | 2020-10-07 | Release date: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis. Proc.Natl.Acad.Sci.USA, 117, 2020
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5UQ7
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![BU of 5uq7 by Molmil](/molmil-images/mine/5uq7) | 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA ("in" conformation) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhang, Y, Hong, S, Skiniotis, G, Dunham, C.M. | Deposit date: | 2017-02-07 | Release date: | 2018-03-07 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel. Structure, 26, 2018
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5UQ8
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![BU of 5uq8 by Molmil](/molmil-images/mine/5uq8) | 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA ("out" conformation) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhang, Y, Hong, S, Skiniotis, G, Dunham, C.M. | Deposit date: | 2017-02-07 | Release date: | 2018-03-07 | Last modified: | 2018-03-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel. Structure, 26, 2018
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8IO3
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![BU of 8io3 by Molmil](/molmil-images/mine/8io3) | Cryo-EM structure of human HCN3 channel with cilobradine | Descriptor: | 3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Authors: | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | Deposit date: | 2023-03-10 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structure of human HCN3 channel with cilobradine To Be Published
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6YXX
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![BU of 6yxx by Molmil](/molmil-images/mine/6yxx) | State A of the Trypanosoma brucei mitoribosomal large subunit assembly intermediate | Descriptor: | 12S ribosomal RNA, 50S ribosomal protein L13, putative, ... | Authors: | Jaskolowski, M, Ramrath, D.J.F, Bieri, P, Niemann, M, Mattei, S, Calderaro, S, Leibundgut, M.A, Horn, E.K, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2020-05-04 | Release date: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis. Mol.Cell, 79, 2020
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8KGW
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![BU of 8kgw by Molmil](/molmil-images/mine/8kgw) | Molecular mechanism of prostaglandin transporter SLCO2A1 | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Solute carrier organic anion transporter family member 2A1 | Authors: | Li, Y.H, Qu, Q.H, Zhu, Z.N, Chao, Y.L, Zhou, Z.X. | Deposit date: | 2023-08-19 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular mechanism of prostaglandin transporter SLCO2A1 To Be Published
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5MV9
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![BU of 5mv9 by Molmil](/molmil-images/mine/5mv9) | Structure of human Myosin 7a C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain | Descriptor: | ACETATE ION, Unconventional myosin-VIIa, cDNA FLJ51329, ... | Authors: | Yu, I, Sourigues, Y, Titus, M.A, Houdusse, A. | Deposit date: | 2017-01-16 | Release date: | 2017-07-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Myosin 7 and its adaptors link cadherins to actin. Nat Commun, 8, 2017
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5MV8
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![BU of 5mv8 by Molmil](/molmil-images/mine/5mv8) | Structure of human Myosin 7b C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain | Descriptor: | GLYCEROL, MAGNESIUM ION, Unconventional myosin-VIIb, ... | Authors: | Yu, I, Sourigues, Y, Titus, M.A, Houdusse, A. | Deposit date: | 2017-01-16 | Release date: | 2017-07-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Myosin 7 and its adaptors link cadherins to actin. Nat Commun, 8, 2017
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6PZT
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![BU of 6pzt by Molmil](/molmil-images/mine/6pzt) | cryo-EM structure of human NKCC1 | Descriptor: | Solute carrier family 12 member 2 | Authors: | Cao, E, Wang, Q, Yang, X. | Deposit date: | 2019-08-01 | Release date: | 2020-03-25 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy. Nat Commun, 11, 2020
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7E2G
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![BU of 7e2g by Molmil](/molmil-images/mine/7e2g) | Cryo-EM structure of hDisp1NNN-3C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1,Protein dispatched homolog 1 | Authors: | Li, W, Wang, L, Gong, X. | Deposit date: | 2021-02-05 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun, 12, 2021
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7E2I
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![BU of 7e2i by Molmil](/molmil-images/mine/7e2i) | Cryo-EM structure of hDisp1NNN-ShhN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1, ... | Authors: | Li, W, Wang, L, Gong, X. | Deposit date: | 2021-02-05 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (4.07 Å) | Cite: | Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun, 12, 2021
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3ECY
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8BQU
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![BU of 8bqu by Molmil](/molmil-images/mine/8bqu) | Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament | Descriptor: | Choriogenin H, Zona pellucida sperm-binding protein 3, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Bokhove, M, de Sanctis, D, Yasumasu, S, Jovine, L. | Deposit date: | 2022-11-21 | Release date: | 2024-03-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell, 187, 2024
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8EQ6
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![BU of 8eq6 by Molmil](/molmil-images/mine/8eq6) | PD1 signaling receptor bound to FAB Complex | Descriptor: | Antibody FAB heavy chain, Antibody FAB light chain, Programmed cell death protein 1 | Authors: | Bjorkelid, C, Paluch, C, Robertson, N.J. | Deposit date: | 2022-10-07 | Release date: | 2023-10-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases. Immunity, 57, 2024
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1AYI
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![BU of 1ayi by Molmil](/molmil-images/mine/1ayi) | COLICIN E7 IMMUNITY PROTEIN IM7 | Descriptor: | COLICIN E IMMUNITY PROTEIN 7 | Authors: | Dennis, C.A, Pauptit, R.A, Wallis, R, James, R, Moore, G.R, Kleanthous, C. | Deposit date: | 1997-11-04 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity. Biochem.J., 333 ( Pt 1), 1998
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8INZ
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![BU of 8inz by Molmil](/molmil-images/mine/8inz) | Cryo-EM structure of human HCN3 channel in apo state | Descriptor: | 4-[[(2~{S},4~{a}~{R},6~{S},8~{a}~{S})-6-[(4~{S},5~{R})-4-[(2~{S})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Authors: | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | Deposit date: | 2023-03-10 | Release date: | 2024-04-10 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J.Biol.Chem., 300, 2024
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5WJF
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![BU of 5wjf by Molmil](/molmil-images/mine/5wjf) | Crystal structure of murine 4-1BB from HEK293T cells in P21212 space group | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 9 | Authors: | Zajonc, D.M, Doukov, T, Bitra, A. | Deposit date: | 2017-07-21 | Release date: | 2017-12-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling. J. Biol. Chem., 293, 2018
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