1M7A
| CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 7-[2-methoxy-1-(methoxymethyl)ethyl]-7H-pyrrolo[3,2-f] quinazoline-1,3-diamine (GW557) | Descriptor: | 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Whitlow, M, Howard, A.J, Kuyper, L.F. | Deposit date: | 2002-07-19 | Release date: | 2003-03-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex. J.Biol.Chem., 272, 1997
|
|
1LWG
| Multiple Methionine Substitutions are Tolerated in T4 Lysozyme and have Coupled Effects on Folding and Stability | Descriptor: | 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, Lysozyme, ... | Authors: | Gassner, N.C, Baase, W.A, Mooers, B.H.M, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.M. | Deposit date: | 2002-05-31 | Release date: | 2003-05-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. Biophys.Chem., 100, 2003
|
|
4YO8
| Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)(hexyl)amino)methanol | Descriptor: | Aminodeoxyfutalosine nucleosidase, ZINC ION, {[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](hexyl)amino}methanol | Authors: | Cameron, S.A, Wang, S, Almo, S.C, Schramm, V.L. | Deposit date: | 2015-03-11 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | New Antibiotic Candidates against Helicobacter pylori. J.Am.Chem.Soc., 137, 2015
|
|
4YQH
| 2-[2-(4-Phenyl-1H-imidazol-2-yl)ethyl]quinoxaline (Sunovion Compound 14) co-crystallized with PDE10A | Descriptor: | 2-[2-(4-phenyl-1H-imidazol-2-yl)ethyl]quinoxaline, MAGNESIUM ION, ZINC ION, ... | Authors: | Burdi, D, Herman, L, Wang, T. | Deposit date: | 2015-03-13 | Release date: | 2015-04-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.308 Å) | Cite: | Evolution and synthesis of novel orally bioavailable inhibitors of PDE10A. Bioorg.Med.Chem.Lett., 25, 2015
|
|
1LWN
| Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, alpha-D-glucopyranose, glycogen phosphorylase | Authors: | Oikonomakos, N.G, Chrysina, E.D, Kosmopoulou, M, Leonidas, D.D. | Deposit date: | 2002-06-01 | Release date: | 2002-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution BIOCHEM.BIOPHYS.ACTA PROTEINS & PROTEOMICS, 1647, 2003
|
|
4YQW
| Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. | Deposit date: | 2015-03-13 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.064 Å) | Cite: | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
|
|
1M7T
| |
1LXG
| |
4YOB
| Crystal Structure of Apo HIV-1 Protease MDR769 L33F | Descriptor: | HIV-1 Protease | Authors: | Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Ross, K, Brunzelle, J.S, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C. | Deposit date: | 2015-03-11 | Release date: | 2015-07-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.504 Å) | Cite: | The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops. Biochem Biophys Rep, 2, 2015
|
|
4YRA
| mouse TDH in the apo form | Descriptor: | L-threonine 3-dehydrogenase, mitochondrial | Authors: | He, C, Li, F. | Deposit date: | 2015-03-14 | Release date: | 2016-02-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis J.Struct.Biol., 192, 2015
|
|
1M8U
| Crystal Structure of Bovine gamma-E at 1.65 Ang Resolution | Descriptor: | gamma-E | Authors: | Mayer, C, Agueznay, N, Skouri-Panet, F, Prat, K, Putilina, T, Biarrotte-Sorin, S, Tardieu, A. | Deposit date: | 2002-07-26 | Release date: | 2003-08-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structure of Bovine gamma-E To be Published
|
|
4YOF
| DosS GAFA Domain Reduced Nitric Oxide Bound Crystal Structure | Descriptor: | NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE, Redox sensor histidine kinase response regulator DevS | Authors: | Madrona, Y. | Deposit date: | 2015-03-11 | Release date: | 2016-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography. J.Biol.Chem., 290, 2015
|
|
1LYO
| CROSS-LINKED LYSOZYME CRYSTAL IN NEAT WATER | Descriptor: | LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-05 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
|
|
4YS7
| Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline (compound 39) with PDE10A | Descriptor: | 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline, MAGNESIUM ION, ZINC ION, ... | Authors: | Burdi, D.F, Herman, L, Wang, T. | Deposit date: | 2015-03-16 | Release date: | 2015-04-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Evolution and synthesis of novel orally bioavailable inhibitors of PDE10A. Bioorg.Med.Chem.Lett., 25, 2015
|
|
1M8W
| CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-19 RNA | Descriptor: | 5'-R(P*UP*GP*UP*AP*UP*AP*U)-3', 5'-R(P*UP*GP*UP*CP*CP*AP*G)-3', 5'-R(P*UP*UP*GP*UP*AP*UP*AP*U)-3', ... | Authors: | Wang, X, McLachlan, J, Zamore, P.D, Hall, T.M.T. | Deposit date: | 2002-07-26 | Release date: | 2002-09-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | MODULAR RECOGNITION OF RNA BY A HUMAN PUMILIO-HOMOLOGY DOMAIN CELL(CAMBRIDGE,MASS.), 110, 2002
|
|
4YON
| P-Rex1:Rac1 complex | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 | Authors: | Lucato, C.M, Whisstock, J.C, Ellisdon, A.M. | Deposit date: | 2015-03-11 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J.Biol.Chem., 290, 2015
|
|
1LYV
| High-resolution structure of the catalytically inactive yersinia tyrosine phosphatase C403A mutant in complex with phosphate. | Descriptor: | CHLORIDE ION, PHOSPHATE ION, PROTEIN-TYROSINE PHOSPHATASE YOPH | Authors: | Evdokimov, A.G, Waugh, D.S, Routzahn, K, Tropea, J, Cherry, S. | Deposit date: | 2002-06-08 | Release date: | 2002-07-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.363 Å) | Cite: | High-resolution structure of the catalytically inactive yersinia tyrosine phosphatase C403A mutant in complex with phosphate. To be Published
|
|
4YSF
| |
1M9B
| Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with gamma-glutamyl[S-(2-iodobenzyl)cysteinyl]glycine | Descriptor: | GAMMA-GLUTAMYL[S-(2-IODOBENZYL)CYSTEINYL]GLYCINE, Glutathione S-Transferase 26 kDa | Authors: | Cardoso, R.M.F, Daniels, D.S, Bruns, C.M, Tainer, J.A. | Deposit date: | 2002-07-28 | Release date: | 2003-03-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Characterization of the electrophile
binding site and substrate binding
mode of the 26-kDa glutathione
S-transferase from Schistosoma
japonicum PROTEINS: STRUCT.,FUNCT.,GENET., 51, 2003
|
|
1LZC
| DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME | Authors: | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | Deposit date: | 1995-02-10 | Release date: | 1995-05-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity. J.Mol.Biol., 247, 1995
|
|
4YSO
| Copper nitrite reductase from Geobacillus thermodenitrificans - 0.064 MGy | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, Nitrite reductase, ... | Authors: | Fukuda, Y, Tse, K.M, Suzuki, M, Diederichs, K, Hirata, K, Nakane, T, Sugahara, M, Nango, E, Tono, K, Joti, Y, Kameshima, T, Song, C, Hatsui, T, Yabashi, M, Nureki, O, Matsumura, H, Inoue, T, Iwata, S, Mizohata, E. | Deposit date: | 2015-03-17 | Release date: | 2016-02-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography J.Biochem., 159, 2016
|
|
4YOY
| |
1M9G
| Solution structure of G16A-MNEI, a structural mutant of single chain monellin MNEI | Descriptor: | Monellin chain B and Monellin chain A | Authors: | Spadaccini, R, Trabucco, F, Saviano, G, Picone, D, Crescenzi, O, Tancredi, T, Temussi, P.A. | Deposit date: | 2002-07-29 | Release date: | 2003-06-10 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The Mechanism of Interaction of Sweet Proteins with the T1R2-T1R3 Receptor: Evidence from the Solution Structure of G16A-MNEI J.MOL.BIOL., 328, 2003
|
|
4YPE
| ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM) | Descriptor: | Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION | Authors: | Rogawski, D.S, Ndoj, J, Cho, H.J, Maillard, I, Grembecka, J, Cierpicki, T. | Deposit date: | 2015-03-12 | Release date: | 2015-09-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry, 54, 2015
|
|
1MA9
| Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Alpha Skeletal Muscle, ... | Authors: | Verboven, C, Bogaerts, I, Waelkens, E, Rabijns, A, Van Baelen, H, Bouillon, R, De Ranter, C. | Deposit date: | 2002-08-02 | Release date: | 2003-02-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Actin-DBP: the perfect structural fit? Acta Crystallogr.,Sect.D, 59, 2003
|
|