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5SDB
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BU of 5sdb by Molmil
Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate
Descriptor: 1,2-ETHANEDIOL, Dihydrofolate reductase, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-12-20
Release date:2022-02-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate
to be published
5SD6
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BU of 5sd6 by Molmil
Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892
Descriptor: 1,2-ETHANEDIOL, 6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-12-20
Release date:2022-02-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892
to be published
3G7Z
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BU of 3g7z by Molmil
CcdB dimer in complex with two C-terminal CcdA domains
Descriptor: Cytotoxic protein ccdB, Protein ccdA
Authors:De Jonge, N, Loris, R, Garcia-Pino, A, Buts, L.
Deposit date:2009-02-11
Release date:2009-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Rejuvenation of CcdB-Poisoned Gyrase by an Intrinsically Disordered Protein Domain.
Mol.Cell, 35, 2009
3JR9
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BU of 3jr9 by Molmil
Crystal structure of Fis bound to 27 bp optimal binding sequence F2
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
3JRD
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BU of 3jrd by Molmil
Crystal structure of Fis bound to 27 bp DNA F25 containing T2A3 sequence at center
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
3JRG
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BU of 3jrg by Molmil
Crystal structure of Fis bound to 27 bp non consensus sequence DNA F18
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
3K26
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BU of 3k26 by Molmil
Complex structure of EED and trimethylated H3K4
Descriptor: HISTONE PEPTIDE, Polycomb protein EED
Authors:Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2009-09-29
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Proc.Natl.Acad.Sci.USA, 107, 2010
3K0F
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BU of 3k0f by Molmil
Crystal structure of the phosphorylation-site double mutant T426A/T432A of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-24
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
3K27
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BU of 3k27 by Molmil
Complex structure of EED and trimethylated H3K9
Descriptor: HISTONE PEPTIDE, Polycomb protein EED
Authors:Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2009-09-29
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Proc.Natl.Acad.Sci.USA, 107, 2010
3JZM
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BU of 3jzm by Molmil
Crystal structure of the phosphorylation-site mutant T432A of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase kaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-23
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
3JZN
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BU of 3jzn by Molmil
Structure of EED in apo form
Descriptor: Polycomb protein EED
Authors:Xu, C, Bian, C.B, Ouyang, H, Qiu, W, MacKenzie, F, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2009-09-23
Release date:2009-12-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Proc.Natl.Acad.Sci.USA, 107, 2010
3K09
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BU of 3k09 by Molmil
Crystal structure of the phosphorylation-site mutant S431D of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase kaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-24
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
3K0E
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BU of 3k0e by Molmil
Crystal structure of the phosphorylation-site mutant T426N of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-24
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
3JRB
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BU of 3jrb by Molmil
Crystal structure of Fis bound to 27 bp DNA F24 containing T-tract at center
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
3JRH
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BU of 3jrh by Molmil
Crystal structure of Fis bound to 27 bp non consensus sequence DNA F21
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
3K0A
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BU of 3k0a by Molmil
Crystal structure of the phosphorylation-site mutant S431A of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-24
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
3K0C
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BU of 3k0c by Molmil
Crystal structure of the phosphorylation-site double mutant S431A/T432E of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-24
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
3JRC
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BU of 3jrc by Molmil
Crystal structure of Fis bound to 27 bp DNA F29 containing 5 G/Cs at center
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
3JRI
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BU of 3jri by Molmil
Crystal structure of Fis bound to 27 bp non consensus sequence DNA F23
Descriptor: DNA (27-MER), DNA-binding protein fis
Authors:Stella, S, Cascio, D, Johnson, R.C.
Deposit date:2009-09-08
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Genes Dev., 24, 2010
5SUW
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BU of 5suw by Molmil
Crystal Structure of ToxT from Vibrio Cholerae O395 bound to 3-(8-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl)propanoic acid
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(1R)-8-methyl-1,2,3,4-tetrahydronaphthalen-1-yl]propanoic acid, TCP pilus virulence regulatory protein
Authors:Kull, F.J, Kelley, A.R.
Deposit date:2016-08-04
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of ToxT from Vibrio Cholerae O395 bound to 3-(8-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl)propanoic acid
To Be Published
3JTG
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BU of 3jtg by Molmil
Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
Descriptor: DNA (5'-D(*CP*AP*AP*AP*CP*AP*GP*GP*AP*AP*AP*CP*TP*CP*CP*T)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*GP*TP*TP*TP*CP*CP*TP*GP*TP*TP*T)-3'), ETS-related transcription factor Elf-3
Authors:Tahirov, T.H, Babayeva, N.D, Agarkar, V.B, Rizzino, A.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA.
J.Mol.Biol., 397, 2010
3M4T
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BU of 3m4t by Molmil
Crystal structure of the BTB domain from Kaiso/ZBTB33, form I
Descriptor: SULFATE ION, Transcriptional regulator Kaiso
Authors:Stogios, P.J, Chen, L, Prive, G.G.
Deposit date:2010-03-11
Release date:2011-04-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the BTB domain from Kaiso/ZBTB33, form I
TO BE PUBLISHED
1REP
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BU of 1rep by Molmil
CRYSTAL STRUCTURE OF REPLICATION INITIATOR PROTEIN REPE54 OF MINI-F PLASMID COMPLEXED WITH AN ITERON DNA
Descriptor: DNA (5'-D(*CP*CP*TP*GP*TP*GP*AP*CP*AP*AP*AP*TP*TP*GP*CP*CP*CP*TP*CP*AP*GP*T)-3'), DNA (5'-D(*CP*TP*GP*AP*GP*GP*GP*CP*AP*AP*TP*TP*TP*GP*TP*CP*AP*CP*AP*GP*GP*T)-3'), MAGNESIUM ION, ...
Authors:Komori, H, Matsunaga, F, Higuchi, Y, Ishiai, M, Wada, C, Miki, K.
Deposit date:1999-04-29
Release date:2000-02-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a prokaryotic replication initiator protein bound to DNA at 2.6 A resolution.
EMBO J., 18, 1999
5SD8
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BU of 5sd8 by Molmil
Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture)
Descriptor: (2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-12-20
Release date:2022-02-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture)
to be published
3L3R
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BU of 3l3r by Molmil
Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants
Descriptor: 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Cody, V.
Deposit date:2009-12-17
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.
Antimicrob.Agents Chemother., 57, 2013

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數據於2024-07-24公開中

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