PDB: 1828 resultsInfo pagesStatus searchChemie searchBIRD

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8F8M	LRH-1 bound to small molecule Tet and fragment of coactivator Tif2 Descriptor: (1~{R},3~{a}~{R},6~{a}~{R})-4-phenyl-3~{a}-(1-phenylethenyl)-5-[9-(1~{H}-1,2,3,4-tetrazol-5-yl)nonyl]-2,3,6,6~{a}-tetrahydro-1~{H}-pentalen-1-ol, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 Authors: Cato, M.L, Ortlund, E.A. Deposit date: 2022-11-22 Release date: 2023-11-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Isosteric improvements to liver receptor homolog-1 small molecule modulators To Be Published
8FAV	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 5 ANDINDAZOLE ACID BOUND IN H12-POCKET Descriptor: 3-cyano-N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)benzamide, 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-3-fluorobenzoic acid, Nuclear receptor ROR-gamma, ... Authors: Vajdos, F.F. Deposit date: 2022-11-28 Release date: 2023-03-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023
8FB1	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 6a ANDINDAZOLE ACID BOUND IN H12-POCKET Descriptor: 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-3-fluorobenzoic acid, N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)-4-fluorobenzene-1-sulfonamide, Nuclear receptor ROR-gamma Authors: Vajdos, F.F. Deposit date: 2022-11-29 Release date: 2023-03-01 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023
8FB2	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 8 ANDINDAZOLE ACID BOUND IN H12-POCKET Descriptor: (1R,15S)-16-(cyclopropylacetyl)-5-fluoro-20-methyl-9lambda~6~-thia-1,8,16-triazatricyclo[13.3.1.1~3,7~]icosa-3(20),4,6-triene-9,9-dione, 4-[1-(2,6-dichlorobenzoyl)-4-fluoro-1H-indazol-3-yl]benzoic acid, Nuclear receptor ROR-gamma Authors: Vajdos, F.F. Deposit date: 2022-11-29 Release date: 2023-03-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FFV	Cryo-EM structure of the GR-Hsp90-FKBP52 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FGZ	Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L with DHT Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION Authors: Doamekpor, S.K, Tong, L. Deposit date: 2022-12-13 Release date: 2023-04-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.61 Å) Cite: A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FH2	Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y with DHT Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION Authors: Doamekpor, S.K, Tong, L. Deposit date: 2022-12-13 Release date: 2023-04-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.59 Å) Cite: A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FGY	Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L/T878A with DHT Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor Authors: Doamekpor, S.K, Tong, L. Deposit date: 2022-12-13 Release date: 2023-04-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FH1	Crystal structure of mutant Androgen Receptor ligand binding domain F877L/T878A with DHT Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION Authors: Doamekpor, S.K, Tong, L. Deposit date: 2022-12-13 Release date: 2023-04-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.69 Å) Cite: A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FH0	Crystal structure of mutant Androgen Receptor ligand binding domain H875Y/F877L/T878A with DHT Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION Authors: Doamekpor, S.K, Tong, L. Deposit date: 2022-12-13 Release date: 2023-04-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.59 Å) Cite: A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations. Acta Crystallogr.,Sect.F, 79, 2023
8FHE	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662 Descriptor: 2-chloro-5-nitro-N-phenylbenzamide, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma Authors: Shang, J, Kojetin, D.J. Deposit date: 2022-12-14 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662 To Be Published
8FHG	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437 Descriptor: N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma Authors: Shang, J, Kojetin, D.J. Deposit date: 2022-12-14 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437 To Be Published
8FHF	Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 Descriptor: N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide, Peroxisome proliferator-activated receptor gamma, nonanoic acid Authors: Shang, J, Kojetin, D.J. Deposit date: 2022-12-14 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 To Be Published
8C0C	X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46 Descriptor: (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one, Peroxisome proliferator-activated receptor gamma Authors: Capelli, D, Montanari, R, Pochetti, G, Villa, S, Meneghetti, F. Deposit date: 2022-12-16 Release date: 2023-04-26 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13, 2023
8C1L	Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide Descriptor: 1,2-ETHANEDIOL, Hepatocyte nuclear factor 4-alpha, Nuclear receptor coactivator 2, ... Authors: Ni, X, Merk, D, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-12-20 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide To Be Published
8FKF	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR36706 Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-(5-fluoropyridin-3-yl)-5-nitrobenzamide, GLYCEROL, ... Authors: MacTavish, B.S, Kojetin, D.J. Deposit date: 2022-12-21 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR36706 To Be Published
8FKD	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33068 Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-(6-cyanopyridin-3-yl)-5-nitrobenzamide, Nuclear receptor corepressor 1, ... Authors: MacTavish, B.S, Kojetin, D.J. Deposit date: 2022-12-21 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33068 To Be Published
8FKG	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33486 Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-(5-cyanopyridin-2-yl)-5-nitrobenzamide, GLYCEROL, ... Authors: MacTavish, B.S, Kojetin, D.J. Deposit date: 2022-12-21 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33486 To Be Published
8FKC	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33544 Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-(5-cyanopyridin-3-yl)-5-nitrobenzamide, Nuclear receptor corepressor 1, ... Authors: MacTavish, B.S, Kojetin, D.J. Deposit date: 2022-12-21 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33544 To Be Published
8FKE	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR32904 Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-(2-methylpyridin-4-yl)-5-nitrobenzamide, Nuclear receptor corepressor 1, ... Authors: MacTavish, B.S, Kojetin, D.J. Deposit date: 2022-12-21 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR32904 To Be Published
8HUL	X-ray structure of human PPAR delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization Descriptor: 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid, Peroxisome proliferator-activated receptor delta Authors: Kamata, S, Honda, A, Machida, Y, Uchii, K, Shiiyama, Y, Masuda, R, Oyama, T, Ishii, I. Deposit date: 2022-12-24 Release date: 2023-08-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.461 Å) Cite: Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023
8HUN	X-ray structure of human PPAR alpha ligand binding domain-seladelpar co-crystals obtained by cross-seeding Descriptor: GLYCEROL, Peroxisome proliferator-activated receptor alpha, Seladelpar Authors: Kamata, S, Honda, A, Machida, Y, Uchii, K, Shiiyama, Y, Masuda, R, Iino, S, Oyama, T, Ishii, I. Deposit date: 2022-12-24 Release date: 2023-08-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023
8HUK	X-ray structure of human PPAR alpha ligand binding domain-lanifibranor-SRC1 coactivator peptide co-crystals obtained by soaking Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid, Peroxisome proliferator-activated receptor alpha Authors: Kamata, S, Ishikawa, R, Akahane, M, Honda, A, Oyama, T, Ishii, I. Deposit date: 2022-12-24 Release date: 2023-08-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.981 Å) Cite: Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023
8HUQ	X-ray structure of human PPAR alpha ligand binding domain-elafibranor-SRC1 coactivator peptide co-crystals obtained by soaking Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 2-[2,6-dimethyl-4-[(~{E})-3-(4-methylsulfanylphenyl)-3-oxidanylidene-prop-1-enyl]phenoxy]-2-methyl-propanoic acid, GLYCEROL, ... Authors: Kamata, S, Ishikawa, R, Akahane, M, Honda, A, Oyama, T, Ishii, I. Deposit date: 2022-12-24 Release date: 2023-08-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12, 2023

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