2M08
 
 | |
5XZC
 | | Cryo-EM structure of p300-p53 protein complex | | Descriptor: | Cellular tumor antigen p53, Histone acetyltransferase p300 | | Authors: | Ghosh, R, Roy, S, Sengupta, J. | | Deposit date: | 2017-07-12 | | Release date: | 2019-01-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (10.7 Å) | | Cite: | Tumor suppressor p53-mediated structural reorganization of the transcriptional coactivator p300.
Biochemistry, 2019
|
|
4HJE
 | | Crystal structure of p53 core domain in complex with DNA | | Descriptor: | Cellular tumor antigen p53, DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), ... | | Authors: | Chen, Y, Chen, L. | | Deposit date: | 2012-10-12 | | Release date: | 2013-07-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.907 Å) | | Cite: | Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.
Nucleic Acids Res., 41, 2013
|
|
2VGC
 | | GAMMA-CHYMOTRYPSIN D-PARA-CHLORO-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | | Descriptor: | D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION | | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | | Deposit date: | 1997-05-01 | | Release date: | 1997-11-12 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
Biochemistry, 37, 1998
|
|
6GCH
 | | STRUCTURE OF CHYMOTRYPSIN-*TRIFLUOROMETHYL KETONE INHIBITOR COMPLEXES. COMPARISON OF SLOWLY AND RAPIDLY EQUILIBRATING INHIBITORS | | Descriptor: | 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE), GAMMA-CHYMOTRYPSIN A | | Authors: | Brady, K, Wei, A, Ringe, D, Abeles, R.H. | | Deposit date: | 1990-04-06 | | Release date: | 1990-10-15 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors.
Biochemistry, 29, 1990
|
|
6NMI
 | | Cryo-EM structure of the human TFIIH core complex | | Descriptor: | CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription and DNA repair factor IIH helicase subunit XPD, ... | | Authors: | Greber, B.J, Toso, D, Fang, J, Nogales, E. | | Deposit date: | 2019-01-10 | | Release date: | 2019-03-13 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | The complete structure of the human TFIIH core complex.
Elife, 8, 2019
|
|
5MG7
 | | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2) | | Descriptor: | Cellular tumor antigen p53, DNA, ZINC ION | | Authors: | Rozenberg, H, Braeuning, B, Golovenko, D, Shakked, Z. | | Deposit date: | 2016-11-21 | | Release date: | 2018-06-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
|
|
6ZNC
 | | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I) | | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | | Authors: | Rozenberg, H, Degtjarik, O, Diskin-Posner, Y, Shakked, Z. | | Deposit date: | 2020-07-06 | | Release date: | 2021-12-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
|
|
8XP5
 | | The Crystal Structure of p53/BCL-xL fusion complex from Biortus. | | Descriptor: | Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION | | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | | Deposit date: | 2024-01-03 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
To Be Published
|
|
4VGC
 | | GAMMA-CHYMOTRYPSIN D-NAPHTHYL-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | | Descriptor: | D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION | | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | | Deposit date: | 1997-05-01 | | Release date: | 1997-11-12 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
Biochemistry, 37, 1998
|
|
4Q2K
 | | Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b | | Descriptor: | (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide, Chymotrypsinogen A | | Authors: | Chan, H.Y, Bruning, J.B, Abell, A.D. | | Deposit date: | 2014-04-09 | | Release date: | 2014-07-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Macrocyclic protease inhibitors with reduced peptide character.
Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
1CA0
 | | BOVINE CHYMOTRYPSIN COMPLEXED TO APPI | | Descriptor: | BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | | Authors: | Scheidig, A.J, Kossiakoff, A.A. | | Deposit date: | 1997-01-23 | | Release date: | 1997-07-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
|
|
1CBW
 | | BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI | | Descriptor: | BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION | | Authors: | Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. | | Deposit date: | 1996-12-22 | | Release date: | 1997-07-23 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
|
|
4QO1
 | | p53 DNA binding domain in complex with Nb139 | | Descriptor: | Cellular tumor antigen p53, Nb139 Nanobody against the DNA-binding domain of p53, ZINC ION | | Authors: | De Gieter, S, Bethuyne, J, Gettemans, J, Garcia-Pino, A, Loris, R. | | Deposit date: | 2014-06-19 | | Release date: | 2014-10-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.924 Å) | | Cite: | A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.
Nucleic Acids Res., 42, 2014
|
|
5J4Q
 | |
1T8O
 | | CRYSTAL STRUCTURE OF THE P1 TRP BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | | Descriptor: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | | Authors: | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | | Deposit date: | 2004-05-13 | | Release date: | 2005-03-08 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants.
J.Mol.Biol., 344, 2004
|
|
6UE7
 | | Structure of dimeric sIgA complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | | Authors: | Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L. | | Deposit date: | 2019-09-20 | | Release date: | 2020-02-19 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of the secretory immunoglobulin A core.
Science, 367, 2020
|
|
7UVL
 | | IgA1 Protease with IgA1 substrate | | Descriptor: | Immunoglobulin alpha-1 heavy chain, Immunoglobulin alpha-1 heavy constant, Immunoglobulin alpha-1 light chain, ... | | Authors: | Eisenmesser, Z.E, Zheng, H. | | Deposit date: | 2022-05-02 | | Release date: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases.
Commun Biol, 5, 2022
|
|
4XR8
 | | Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. | | Deposit date: | 2015-01-20 | | Release date: | 2016-02-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Nature, 529, 2016
|
|
7V97
 | | Arsenic-bound p53 DNA-binding domain mutant V272M | | Descriptor: | ARSENIC, Cellular tumor antigen p53, ZINC ION | | Authors: | Lu, M, Xing, Y.F, Wang, Z.Y, Ni, Y, Song, H.X. | | Deposit date: | 2021-08-24 | | Release date: | 2022-08-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties.
Sci Transl Med, 15, 2023
|
|
5CHA
 | |
7XZZ
 | | Cryo-EM structure of the nucleosome in complex with p53 | | Descriptor: | Cellular tumor antigen p53, DNA (169-MER), Histone H2A type 1-B/E, ... | | Authors: | Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2022-06-03 | | Release date: | 2022-10-12 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Structural basis for p53 binding to its nucleosomal target DNA sequence.
Pnas Nexus, 1, 2022
|
|
7XZX
 | | Cryo-EM structure of the nucleosome in complex with p53 DNA-binding domain | | Descriptor: | Cellular tumor antigen p53, DNA (193-MER), Histone H2A type 1-B/E, ... | | Authors: | Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2022-06-03 | | Release date: | 2022-10-12 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (4.53 Å) | | Cite: | Structural basis for p53 binding to its nucleosomal target DNA sequence.
Pnas Nexus, 1, 2022
|
|
5ECG
 | | Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) | | Descriptor: | Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ... | | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | | Deposit date: | 2015-10-20 | | Release date: | 2015-12-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX.
Cell Rep, 13, 2015
|
|
7YGI
 | | Crystal structure of p53 DBD domain in complex with azurin | | Descriptor: | Azurin, Cellular tumor antigen p53, PHOSPHATE ION, ... | | Authors: | Jiang, W.X, Zuo, J.Q, Hu, J.J, Chen, X.Q, Ma, L.X, Liu, Z, Xing, Q. | | Deposit date: | 2022-07-11 | | Release date: | 2023-02-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Commun Biol, 6, 2023
|
|
