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1RQI	Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S-Thiolodiphosphate Descriptor: DIMETHYLALLYL S-THIOLODIPHOSPHATE, DIPHOSPHATE, Geranyltranstransferase, ... Authors: Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J. Deposit date: 2003-12-05 Release date: 2004-03-02 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J.Biol.Chem., 279, 2004
6SDQ	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 2m5n Descriptor: 2-methoxy-5-nitro-phenol, Farnesyl diphosphate synthase, SULFATE ION, ... Authors: Magari, F, Heine, A, Klebe, G. Deposit date: 2019-07-29 Release date: 2020-08-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 2m5n To Be Published
6V0K	Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain Descriptor: GLYCEROL, Terpene synthase Authors: Christianson, D.W, Ronnebaum, T.A. Deposit date: 2019-11-18 Release date: 2020-01-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Higher-order oligomerization of a chimeric alpha beta gamma bifunctional diterpene synthase with prenyltransferase and class II cyclase activities is concentration-dependent. J.Struct.Biol., 210, 2020
6SI5	T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one Descriptor: 5-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylcarbonyl)-1-methyl-pyridin-2-one, Farnesyl diphosphate synthase, SULFATE ION Authors: Petrick, J.K, Muenzker, L, Schleberger, C, Cornaciu, I, Clavel, D, Marquez, J.A, Jahnke, W. Deposit date: 2019-08-08 Release date: 2020-08-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.097 Å) Cite: Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6SII	T. brucei FPPS in complex with 1-((1H-indol-3-yl)methyl)-N-(3-chlorobenzyl)piperidin-4-amine Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, ~{N}-[(3-chlorophenyl)methyl]-1-(1~{H}-indol-3-ylmethyl)piperidin-4-amine Authors: Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. Deposit date: 2019-08-09 Release date: 2020-08-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.33 Å) Cite: T. brucei FPPS To Be Published
6SXN	Crystal structure of P212121 apo form of CrtE Descriptor: Geranylgeranyl pyrophosphate synthase Authors: Feng, Y, Morgan, R.M.L, Nixon, P.J. Deposit date: 2019-09-26 Release date: 2020-06-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis. Front Plant Sci, 11, 2020
6SF8	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j51 Descriptor: 3-[(4E)-4-imino-5,6-dimethylfuro[2,3-d]pyrimidin-3(4H)-yl]-N,N-dimethylpropan-1-amine, Farnesyl diphosphate synthase, SULFATE ION Authors: Magari, F, Heine, A, Klebe, G. Deposit date: 2019-08-01 Release date: 2020-08-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j51 To Be Published
1RTR	Crystal Structure of S. Aureus Farnesyl Pyrophosphate Synthase Descriptor: geranyltranstransferase Authors: Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J. Deposit date: 2003-12-10 Release date: 2004-03-02 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J.Mol.Biol., 279, 2004
1RQJ	Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranyltranstransferase, ... Authors: Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J. Deposit date: 2003-12-05 Release date: 2004-03-02 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J.Biol.Chem., 279, 2004
1UBV	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE Descriptor: FARNESYL DIPHOSPHATE SYNTHASE Authors: Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. Deposit date: 1996-10-14 Release date: 1997-03-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1UBW	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE Descriptor: FARNESYL DIPHOSPHATE SYNTHASE, GERANYL DIPHOSPHATE, MAGNESIUM ION Authors: Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. Deposit date: 1996-10-14 Release date: 1997-03-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1UBX	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE Descriptor: FARNESYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION Authors: Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. Deposit date: 1996-10-14 Release date: 1997-03-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1UBY	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE Descriptor: DIMETHYLALLYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION Authors: Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. Deposit date: 1996-10-14 Release date: 1997-03-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1V4E	Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima Descriptor: SULFATE ION, octoprenyl-diphosphate synthase Authors: Guo, R.T, Kuo, C.J, Chou, C.C, Ko, T.P, Shr, H.L, Liang, P.H, Wang, A.H.-J. Deposit date: 2003-11-13 Release date: 2004-03-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination J.Biol.Chem., 279, 2004
1V4I	Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima F132A mutant Descriptor: SULFATE ION, octoprenyl-diphosphate synthase Authors: Guo, R.T, Kuo, C.J, Chou, C.C, Ko, T.P, Shr, H.L, Liang, P.H, Wang, A.H.-J. Deposit date: 2003-11-14 Release date: 2004-03-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination J.Biol.Chem., 279, 2004
1V4H	Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima F52A mutant Descriptor: SULFATE ION, octoprenyl-diphosphate synthase Authors: Guo, R.T, Kuo, C.J, Chou, C.C, Ko, T.P, Shr, H.L, Liang, P.H, Wang, A.H.-J. Deposit date: 2003-11-14 Release date: 2004-03-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination J.Biol.Chem., 279, 2004
1V4K	Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima S77F mutant Descriptor: SULFATE ION, octoprenyl-diphosphate synthase Authors: Guo, R.T, Kuo, C.J, Chou, C.C, Ko, T.P, Shr, H.L, Liang, P.H, Wang, A.H.-J. Deposit date: 2003-11-14 Release date: 2004-03-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination J.Biol.Chem., 279, 2004
1V4J	Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima V73Y mutant Descriptor: SULFATE ION, octoprenyl-diphosphate synthase Authors: Guo, R.T, Kuo, C.J, Chou, C.C, Ko, T.P, Shr, H.L, Liang, P.H, Wang, A.H.-J. Deposit date: 2003-11-14 Release date: 2004-03-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination J.Biol.Chem., 279, 2004
2F9K	Crystal structure of human FPPS in complex with Zoledronate and Zn2+ Descriptor: Farnesyl Diphosphate Synthase, PHOSPHATE ION, ZINC ION, ... Authors: Rondeau, J.-M, Bitsch, F, Bourgier, E, Geiser, M, Hemmig, R, Kroemer, M, Lehmann, S, Ramage, P, Rieffel, S, Strauss, A, Green, J.R, Jahnke, W. Deposit date: 2005-12-06 Release date: 2006-02-28 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. Chemmedchem, 1, 2006
5CG5	Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, MAGNESIUM ION Authors: Yokoyama, T, Mizuguchi, M, Ostermann, A, Kusaka, K, Niimura, N, Schrader, T.E, Tanaka, I. Deposit date: 2015-07-09 Release date: 2015-10-14 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.402 Å), X-RAY DIFFRACTION Cite: Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem., 58, 2015
5CG6	Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ... Authors: Yokoyama, T, Mizuguchi, M, Ostermann, A, Kusaka, K, Niimura, N, Schrader, T.E, Tanaka, I. Deposit date: 2015-07-09 Release date: 2015-10-14 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.7 Å), X-RAY DIFFRACTION Cite: Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem., 58, 2015
5DGS	Crystal structure of human FPPS in complex with the monophosphonate compound 15 Descriptor: Farnesyl pyrophosphate synthase, {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-08-28 Release date: 2016-07-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.62 Å) Cite: A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54, 2015
5DJP	Crystal structure of human FPPS in complex with biaryl compound 5 Descriptor: 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid, Farnesyl pyrophosphate synthase, PHOSPHATE ION Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-09-02 Release date: 2015-09-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
2FOR	Crystal Structure of the Shigella flexneri Farnesyl Pyrophosphate Synthase Complex with an Isopentenyl Pyrophosphate Descriptor: Geranyltranstransferase, ISOPENTYL PYROPHOSPHATE, PHOSPHATE ION Authors: Minasov, G, Brunzelle, J.S, Shuvalova, L, Collart, F.R, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) Deposit date: 2006-01-13 Release date: 2006-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Shigella flexneri Farnesyl Pyrophosphate Synthase Complex with an Isopentenyl Pyrophosphate To be Published
5DJV	Crystal structure of human FPPS in complex with biaryl compound 8e Descriptor: 8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid, Farnesyl pyrophosphate synthase Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-09-02 Release date: 2015-10-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015

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