6FJD
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![BU of 6fjd by Molmil](/molmil-images/mine/6fjd) | Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 4,5-bisphosphate | Descriptor: | (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, GLYCEROL, Protein KIBRA, ... | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | Deposit date: | 2018-01-22 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.898 Å) | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain. J. Biol. Chem., 293, 2018
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6FJC
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![BU of 6fjc by Molmil](/molmil-images/mine/6fjc) | Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 3,4,5-trisphosphate | Descriptor: | (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, GLYCEROL, Protein KIBRA, ... | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | Deposit date: | 2018-01-22 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.598 Å) | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain. J. Biol. Chem., 293, 2018
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6FD0
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![BU of 6fd0 by Molmil](/molmil-images/mine/6fd0) | Human KIBRA C2 domain mutant M734I S735A | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Protein KIBRA | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | Deposit date: | 2017-12-21 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.64215851 Å) | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain. J. Biol. Chem., 293, 2018
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6FLJ
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6FLK
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![BU of 6flk by Molmil](/molmil-images/mine/6flk) | |
4LDC
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![BU of 4ldc by Molmil](/molmil-images/mine/4ldc) | Crystal Structure of DOC2B C2B domain | Descriptor: | CALCIUM ION, CITRATE ANION, Double C2-like domain-containing protein beta | Authors: | Giladi, M, Almagor, L, Hirsch, J.A. | Deposit date: | 2013-06-24 | Release date: | 2013-09-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.264 Å) | Cite: | The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis. J.Mol.Biol., 425, 2013
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4LCV
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![BU of 4lcv by Molmil](/molmil-images/mine/4lcv) | Crystal Structure of DOC2B C2A domain | Descriptor: | BETA-MERCAPTOETHANOL, CALCIUM ION, CITRATE ANION, ... | Authors: | Giladi, M, Almagor, L, Hirsch, J.A. | Deposit date: | 2013-06-23 | Release date: | 2013-09-11 | Last modified: | 2013-11-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis. J.Mol.Biol., 425, 2013
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4NPK
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![BU of 4npk by Molmil](/molmil-images/mine/4npk) | Extended-Synaptotagmin 2, C2A- and C2B-domains, calcium bound | Descriptor: | CALCIUM ION, Extended synaptotagmin-2 | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | Deposit date: | 2013-11-21 | Release date: | 2014-01-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.552 Å) | Cite: | Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2. Structure, 22, 2014
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6EI6
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![BU of 6ei6 by Molmil](/molmil-images/mine/6ei6) | CC2D1B coordinates ESRCT-III activity during the mitotic reformation of the nuclear envelope | Descriptor: | Coiled-coil and C2 domain-containing protein 1-like, DI(HYDROXYETHYL)ETHER, SULFATE ION | Authors: | Ventimiglia, L.N, Cuesta-Geijo, M.A, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, I.M, Olmos, Y, Carlton, J.G, Weissehorn, W, martin-Serrano, J. | Deposit date: | 2017-09-18 | Release date: | 2018-10-10 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (2.461 Å) | Cite: | CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope. Dev. Cell, 47, 2018
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4NPJ
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![BU of 4npj by Molmil](/molmil-images/mine/4npj) | Extended-Synaptotagmin 2, C2A- and C2B-domains | Descriptor: | ACETATE ION, CHLORIDE ION, Extended synaptotagmin-2, ... | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | Deposit date: | 2013-11-21 | Release date: | 2014-01-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2. Structure, 22, 2014
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4NP9
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![BU of 4np9 by Molmil](/molmil-images/mine/4np9) | Structure of Rabphilin C2A domain bound to IP3 | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Rabphilin-3A, SULFATE ION | Authors: | Guillen, J, Ferrer-Orta, C, Buxaderas, M, Perez-Sanchez, D, Guerrero-Valero, M, Luengo-Gil, G, Pous, J, Guerra, P, Gomez-Fernandez, J.C, Verdaguer, N, Corbalan-Garcia, S. | Deposit date: | 2013-11-21 | Release date: | 2013-12-25 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. Proc.Natl.Acad.Sci.USA, 110, 2013
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4NS0
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![BU of 4ns0 by Molmil](/molmil-images/mine/4ns0) | The C2A domain of Rabphilin 3A in complex with PI(4,5)P2 | Descriptor: | Rabphilin-3A, SULFATE ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Guillen, J, Ferrer-Orta, C, Buxaderas, M, Perez-sanchez, D, Guerrero-Valero, M, Luengo-Gil, G, Pous, J, Guerra, P, Gomez-Fernandez, J.C, Verdaguer, N, Corbalan-Garcia, S. | Deposit date: | 2013-11-27 | Release date: | 2013-12-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. Proc.Natl.Acad.Sci.USA, 110, 2013
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5UG6
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![BU of 5ug6 by Molmil](/molmil-images/mine/5ug6) | Perforin C2 Domain - T431D | Descriptor: | IODIDE ION, Perforin-1 | Authors: | Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C. | Deposit date: | 2017-01-07 | Release date: | 2018-02-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin. Cell Death Differ., 25, 2018
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5UG7
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![BU of 5ug7 by Molmil](/molmil-images/mine/5ug7) | Calcium bound Perforin C2 Domain - T431D | Descriptor: | CALCIUM ION, Perforin-1 | Authors: | Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C. | Deposit date: | 2017-01-07 | Release date: | 2018-02-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin. Cell Death Differ., 25, 2018
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7U4Q
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7TX9
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![BU of 7tx9 by Molmil](/molmil-images/mine/7tx9) | Human Synaptotagmin-1 C2B Y312F Ca2+ bound | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Dominguez, M.J, Karmakar, S, Fuson, K.L, Sutton, R.B. | Deposit date: | 2022-02-08 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Human Synaptotagmin-1 C2B Y312F Ca2+ bound To Be Published
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7TUA
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![BU of 7tua by Molmil](/molmil-images/mine/7tua) | |
5VFF
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![BU of 5vff by Molmil](/molmil-images/mine/5vff) | |
5VFG
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![BU of 5vfg by Molmil](/molmil-images/mine/5vfg) | |
5VFE
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![BU of 5vfe by Molmil](/molmil-images/mine/5vfe) | Synaptotagmin 1 C2A domain, lead-bound | Descriptor: | LEAD (II) ION, SULFATE ION, Synaptotagmin-1 | Authors: | Taylor, A.B, Hart, P.J, Igumenova, T.I. | Deposit date: | 2017-04-07 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | High affinity interactions of Pb2+with synaptotagmin I. Metallomics, 10, 2018
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5T0R
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![BU of 5t0r by Molmil](/molmil-images/mine/5t0r) | |
5T0S
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![BU of 5t0s by Molmil](/molmil-images/mine/5t0s) | Synaptotagmin 1 C2B domain, cadmium-bound | Descriptor: | CADMIUM ION, SODIUM ION, Synaptotagmin-1 | Authors: | Taylor, A.B, Hart, P.J, Igumenova, T.I. | Deposit date: | 2016-08-16 | Release date: | 2017-06-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions. Biochemistry, 56, 2017
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2CM5
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![BU of 2cm5 by Molmil](/molmil-images/mine/2cm5) | crystal structure of the C2B domain of rabphilin | Descriptor: | CALCIUM ION, RABPHILIN-3A | Authors: | Schlicker, C, Montaville, P, Sheldrick, G.M, Becker, S. | Deposit date: | 2006-05-04 | Release date: | 2006-12-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | The C2A-C2B Linker Defines the High Affinity Ca2+ Binding Mode of Rabphilin-3A. J.Biol.Chem., 282, 2007
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2D8K
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![BU of 2d8k by Molmil](/molmil-images/mine/2d8k) | |
2DMG
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![BU of 2dmg by Molmil](/molmil-images/mine/2dmg) | |