The C2A domain of Rabphilin 3A in complex with PI(4,5)P2

Summary for 4NS0

Related4NP9 4LT7
DescriptorRabphilin-3A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, SULFATE ION, ... (4 entities in total)
Functional Keywordsc2 domain, calcium binding, phospholipid binding, rabphilin-3a, c2a, synaptic exocytosis metal-binding, protein transport, c-2 domain fold, exophilin-1
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationCell junction, synapse (By similarity) P47709
Total number of polymer chains1
Total molecular weight16148.11
Primary citation
Guillen, J.,Ferrer-Orta, C.,Buxaderas, M.,Perez-Sanchez, D.,Guerrero-Valero, M.,Luengo-Gil, G.,Pous, J.,Guerra, P.,Gomez-Fernandez, J.C.,Verdaguer, N.,Corbalan-Garcia, S.
Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.
Proc.Natl.Acad.Sci.USA, 2013
PubMed: 24302762 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1316179110
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22020.8%00.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution