6FJC

Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 3,4,5-trisphosphate

Summary for 6FJC

• Entry DOI: 10.2210/pdb6fjc/pdb
• Related: 6FB4 6FD0
• Descriptor: Protein KIBRA, GLYCEROL, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, ... (5 entities in total)
• Functional Keywords: c2 domain, kibra, phosphoinositide-binding, membrane interaction, lipid binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 33925.92

Authors

Crennell, S.J.,Posner, M.G.,Bagby, S. (deposition date: 2018-01-22, release date: 2018-05-16, Last modification date: 2024-01-17)

• Primary citation: Posner, M.G.,Upadhyay, A.,Ishima, R.,Kalli, A.C.,Harris, G.,Kremerskothen, J.,Sansom, M.S.P.,Crennell, S.J.,Bagby, S.; Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.; J. Biol. Chem., 293:9335-9344, 2018; PubMed: 29724824; DOI: 10.1074/jbc.RA118.002279

Experimental method

X-RAY DIFFRACTION (2.598 Å)