6FJC

Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 3,4,5-trisphosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein KIBRA	polymer	140	15866.0	2	UniProt (Q8IX03) Pfam (PF00168)	Homo sapiens (Human)	HBeAg-binding protein 3,Kidney and brain protein,KIBRA,WW domain-containing protein 1
2	C, D, E, F, G... (A, B)	GLYCEROL	non-polymer		92.1	15	Chemie (GOL)
3	K (A)	(2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE	non-polymer		716.4	1	Chemie (4PT)
4	S (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	T, U (A, B)	water	water		18.0	94	Chemie (HOH)

Sequence modifications

A, B: 658 - 785 (UniProt: Q8IX03)

PDB	External Database	Details
Met 646	-	initiating methionine
Arg 647	-	expression tag
Gly 648	-	expression tag
Ser 649	-	expression tag
His 650	-	expression tag
His 651	-	expression tag
His 652	-	expression tag
His 653	-	expression tag
His 654	-	expression tag
His 655	-	expression tag
Gly 656	-	expression tag
Ser 657	-	expression tag
Ala 771	Cys 771	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31732.1
Non-Polymers*	Number of molecules	17
	Total formula weight	2193.8
All*	Total formula weight	33925.9

*Water molecules are not included.