PDB: 257 resultsInfo pagesStatus searchChemie searchBIRD

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6FTP	Crystal form 1 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated drug-binding serpin for doxorubicin Descriptor: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, DOXORUBICIN Authors: Schmidt, K, Muller, Y.A. Deposit date: 2018-02-22 Release date: 2018-05-23 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6GWQ	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42) Descriptor: Plasminogen Activator Inhibitor-1, VHH-2g-42 Authors: Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. Deposit date: 2018-06-25 Release date: 2020-01-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
6GWP	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) Descriptor: Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64 Authors: Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. Deposit date: 2018-06-25 Release date: 2020-01-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
6GWN	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) Descriptor: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64 Authors: Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. Deposit date: 2018-06-25 Release date: 2020-01-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
2ZV6	Crystal structure of human squamous cell carcinoma antigen 1 Descriptor: Serpin B3 Authors: Zheng, B, Matoba, Y, Katagiri, C, Hibino, T, Sugiyama, M. Deposit date: 2008-11-01 Release date: 2009-02-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of SCCA1 and insight about the interaction with JNK1 Biochem.Biophys.Res.Commun., 380, 2009
5NBV	Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations Descriptor: Alpha-1-antitrypsin, GLYCEROL Authors: Huntington, J.A, Pomowski, A, Johnson, D.J.D. Deposit date: 2017-03-02 Release date: 2018-03-21 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.73 Å) Cite: CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION To Be Published
5NCW	Structure of the trypsin induced serpin-type proteinase inhibitor, miropin (V367K/K368A mutant). Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.5 Å) Cite: A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5NBU	Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations Descriptor: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID Authors: Huntington, J.A, Pomowski, A, Johnson, D.J.D. Deposit date: 2017-03-02 Release date: 2018-03-21 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.67 Å) Cite: CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION To Be Published
5NCT	Structure of the trypsin induced serpin-type proteinase inhibitor, miropin. Descriptor: ASPARTIC ACID, GLYCEROL, SERINE, ... Authors: Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5NCU	Structure of the subtilisin induced serpin-type proteinase inhibitor, miropin. Descriptor: CHLORIDE ION, GLYCEROL, IODIDE ION, ... Authors: Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5M3X	Crystal structure of human angiotensin I-deleted angiotensinogen Descriptor: Angiotensinogen Authors: Yan, Y, Read, R.J. Deposit date: 2016-10-17 Release date: 2017-12-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
5M3Y	Crystal structure of human glycosylated angiotensinogen Descriptor: Angiotensinogen, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Yan, Y, Read, R.J. Deposit date: 2016-10-17 Release date: 2017-12-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
5NCS	Structure of the native serpin-type proteinase inhibitor, miropin. Descriptor: Serpin Authors: Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3 Å) Cite: A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
1MTP	The X-ray crystal structure of a serpin from a thermophilic prokaryote Descriptor: Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B Authors: Irving, J.A, Cabrita, L.D, Rossjohn, J, Pike, R.N, Bottomley, S.P, Whisstock, J.C. Deposit date: 2002-09-21 Release date: 2003-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment Structure, 11, 2003
1QMB	Cleaved alpha-1-antitrypsin polymer Descriptor: ALPHA-1-ANTITRYPSIN Authors: Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W. Deposit date: 1999-09-24 Release date: 2000-02-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease J.Mol.Biol., 293, 1999
2BEH	Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent antithrombin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... Authors: Johnson, D.J, Luis, S.A, Huntington, J.A. Deposit date: 2005-10-24 Release date: 2005-11-01 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J.Biol.Chem., 281, 2006
1R1L	Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide (formyl-norleucine-LF) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin P14-P9 peptide, Antithrombin-III, ... Authors: Zhou, A, Huntington, J.A, Lomas, D.A, Stein, P.E, Carrell, R.W. Deposit date: 2003-09-24 Release date: 2004-10-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Serpins and the design of peptides to block intermolecular beta-linkages To be Published
1OO8	CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION Descriptor: Alpha-1-antitrypsin precursor Authors: Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G. Deposit date: 2003-03-03 Release date: 2003-08-05 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases J.Biol.Chem., 278, 2003
1OYH	Crystal Structure of P13 Alanine Variant of Antithrombin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... Authors: Johnson, D.J.D, Huntington, J.A. Deposit date: 2003-04-04 Release date: 2004-04-13 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.62 Å) Cite: The influence of hinge region residue Glu-381 on antithrombin allostery and metastability J.Biol.Chem., 279, 2004
1QMN	Alpha1-antichymotrypsin serpin in the delta conformation (partial loop insertion) Descriptor: ALPHA-1-ANTICHYMOTRYPSIN Authors: Gooptu, B, Hazes, B, Lomas, D.A. Deposit date: 1999-10-04 Release date: 2000-01-17 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Inactive Conformation of the Serpin Alpha1-Antichymotrypsin Indicates Two-Stage Insertion of the Reactive Loop: Implications for Inhibitory Function and Conformational Disease Proc.Natl.Acad.Sci.USA, 97, 2000
2DUT	Crystal structure of a M-loop deletion variant of MENT in the native conformation Descriptor: Heterochromatin-associated protein MENT Authors: Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A. Deposit date: 2006-07-26 Release date: 2006-08-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation Embo J., 25, 2006
2B4X	Crystal Structure of Antithrombin-III Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III Authors: Adams, T.E, Huntington, J.A, Johnson, D.J.D, Bock, S.C. Deposit date: 2005-09-27 Release date: 2006-10-10 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of Antithrombin-III To be Published
2ANT	THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE Descriptor: 2-acetamido-2-deoxy-beta-D-allopyranose, ANTITHROMBIN Authors: Skinner, R, Abrahams, J.-P, Whisstock, J.C, Lesk, A.M, Carrell, R.W, Wardell, M.R. Deposit date: 1997-01-28 Release date: 1997-06-16 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J.Mol.Biol., 266, 1997
1OVA	CRYSTAL STRUCTURE OF UNCLEAVED OVALBUMIN AT 1.95 ANGSTROMS RESOLUTION Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, OVALBUMIN Authors: Stein, P.E, Leslie, A.G.W. Deposit date: 1990-11-26 Release date: 1992-04-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J.Mol.Biol., 221, 1991
1UHG	Crystal Structure of S-Ovalbumin At 1.9 Angstrom Resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ovalbumin, ... Authors: Yamasaki, M, Takahashi, N, Hirose, M. Deposit date: 2003-07-03 Release date: 2003-07-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of S-ovalbumin as a Non-loop-inserted Thermostabilized Serpin Form J.Biol.Chem., 278, 2003

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