1Y98
 
 | | Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide. | | Descriptor: | Breast cancer type 1 susceptibility protein, COBALT (II) ION, CtIP PHOSPHORYLATED PEPTIDE, ... | | Authors: | Varma, A.K, Brown, R.S, Birrane, G, Ladias, J.A.A. | | Deposit date: | 2004-12-14 | | Release date: | 2005-08-30 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Biochemistry, 44, 2005
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3ZEE
 | | Electron cyro-microscopy helical reconstruction of Par-3 N terminal domain | | Descriptor: | PARTITIONING DEFECTIVE 3 HOMOLOG | | Authors: | Zhang, Y, Wang, W, Chen, J, Zhang, K, Gao, F, Gong, W, Zhang, M, Sun, F, Feng, W. | | Deposit date: | 2012-12-05 | | Release date: | 2013-10-16 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | Structural Insights Into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain.
Structure, 21, 2013
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4B2D
 | | human PKM2 with L-serine and FBP bound. | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVATE KINASE ISOZYMES M1/M2, ... | | Authors: | Chaneton, B, Hillmann, P, Zheng, L, Martin, A.C.L, Maddocks, O.D.K, Chokkathukalam, A, Coyle, J.E, Jankevics, A, Holding, F.P, Vousden, K.H, Frezza, C, O'Reilly, M, Gottlieb, E. | | Deposit date: | 2012-07-13 | | Release date: | 2012-10-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
Nature, 491, 2012
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4AVU
 | | Crystal structure of human tankyrase 2 in complex with 6(5H)- phenanthridinone | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SULFATE ION, ... | | Authors: | Haikarainen, T, Narwal, M, Lehtio, L. | | Deposit date: | 2012-05-29 | | Release date: | 2012-06-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
Acs Med.Chem.Lett., 5, 2014
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4B6H
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2A20
 | | Solution structure of Rim2 Zinc Finger Domain | | Descriptor: | Regulating synaptic membrane exocytosis protein 2, ZINC ION | | Authors: | Dulubova, I, Lou, X, Lu, J, Huryeva, I, Alam, A, Schneggenburger, R, Sudhof, T.C, Rizo, J. | | Deposit date: | 2005-06-21 | | Release date: | 2005-08-16 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
Embo J., 24, 2005
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2AK5
 | | beta PIX-SH3 complexed with a Cbl-b peptide | | Descriptor: | 8-residue peptide from a signal transduction protein CBL-B, Rho guanine nucleotide exchange factor 7 | | Authors: | Jozic, D, Cardenes, N, Deribe, Y.L, Moncalian, G, Hoeller, D, Groemping, Y, Dikic, I, Rittinger, K, Bravo, J. | | Deposit date: | 2005-08-03 | | Release date: | 2005-10-11 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Cbl promotes clustering of endocytic adaptor proteins.
Nat.Struct.Mol.Biol., 12, 2005
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8W6A
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8W6B
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3E93
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2R4H
 | | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase | | Descriptor: | HISTIDINE, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | | Authors: | Ugochukwu, E, Pilka, E.S, Hozjan, V, Kavanagh, K.L, Cooper, C, Pike, A.C.W, Elkins, J.M, Doyle, D.A, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-08-31 | | Release date: | 2007-10-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase.
To be Published
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4Z7L
 | | Crystal structure of Cas6b | | Descriptor: | Cas6b, RNA (5'-R(*GP*CP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*GP*C)-3'), SULFATE ION | | Authors: | Li, H. | | Deposit date: | 2015-04-07 | | Release date: | 2016-04-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.503 Å) | | Cite: | A Non-Stem-Loop CRISPR RNA Is Processed by Dual Binding Cas6.
Structure, 24, 2016
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3E92
 | | Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor | | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 14, N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide | | Authors: | Somers, D.O, Patel, S. | | Deposit date: | 2008-08-21 | | Release date: | 2008-09-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Kinase array design, back to front: Biaryl amides
Bioorg.Med.Chem.Lett., 18, 2008
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7TUB
 | | The beta-tubulin folding intermediate IV | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Zhao, Y, Frydman, J, Chiu, W. | | Deposit date: | 2022-02-02 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7TRG
 | | The beta-tubulin folding intermediate I | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Zhao, Y, Frydman, J, Chiu, W. | | Deposit date: | 2022-01-28 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7TTN
 | | The beta-tubulin folding intermediate II | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Zhao, Y, Frydman, J, Chiu, W. | | Deposit date: | 2022-02-01 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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4ZPR
 | | Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA | | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... | | Authors: | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | | Deposit date: | 2015-05-08 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.902 Å) | | Cite: | Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
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7TTT
 | | The beta-tubulin folding intermediate III | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Zhao, Y, Frydman, J, Chiu, W. | | Deposit date: | 2022-02-01 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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5X9Y
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5XIT
 | | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form II | | Descriptor: | E3 ubiquitin-protein ligase RNF168, GLYCEROL, PRASEODYMIUM ION, ... | | Authors: | Takahashi, T.S, Sato, Y, Fukai, S. | | Deposit date: | 2017-04-27 | | Release date: | 2018-03-07 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168.
Nat Commun, 9, 2018
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5XHB
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8GW0
 | | Crystal structure of the human dihydroorotase domain in complex with malic acid | | Descriptor: | (2S)-2-hydroxybutanedioic acid, CAD protein, ZINC ION | | Authors: | Yang, P.C, Liu, H.W, Huang, H.Y, Huang, C.Y. | | Deposit date: | 2022-09-16 | | Release date: | 2023-09-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Complexed Crystal Structure of the Dihydroorotase Domain of Human CAD Protein with the Anticancer Drug 5-Fluorouracil.
Biomolecules, 13, 2023
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4ZIF
 | | Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | | Descriptor: | Apoptosis regulator BAX, Bcl-2-like protein 11 | | Authors: | Robin, A.Y, Krishna Kumar, K, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E. | | Deposit date: | 2015-04-28 | | Release date: | 2015-07-22 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.
Cell Death Dis, 6, 2015
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5XHZ
 | | Crystal Structure Analysis of CIN85-SH3B in complex with ARAP1-P2 | | Descriptor: | ACETATE ION, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, ... | | Authors: | Liu, W, Yang, W. | | Deposit date: | 2017-04-25 | | Release date: | 2018-04-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.319 Å) | | Cite: | Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.
Biochemistry, 57, 2018
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2QY7
 | | Crystal structure of human epsinR ENTH domain | | Descriptor: | Clathrin interactor 1 | | Authors: | Miller, S.E, Collins, B.M, McCoy, A.J, Robinson, M.S, Owen, D.J. | | Deposit date: | 2007-08-13 | | Release date: | 2007-11-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.
Nature, 450, 2007
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