PDB: 13422 resultsInfo pagesStatus searchChemie searchBIRD

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6Y7T	Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding Descriptor: 14-3-3 protein sigma, ExoSTWZ molecular tweezer, Exoenzyme S, ... Authors: Guillory, X, Ottmann, C. Deposit date: 2020-03-02 Release date: 2021-03-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143, 2021
6YIA	14-3-3 sigma in complex with SMAD2 pS465 peptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Kiehstaller, S, Graf, S, Hennig, S. Deposit date: 2020-04-01 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YIB	14-3-3 sigma in complex with SMAD3 pS423 peptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Kiehstaller, S, Graf, S, Hennig, S. Deposit date: 2020-04-01 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YIC	14-3-3 sigma in complex with SMAD4 pS403 peptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, GLYCEROL, ... Authors: Kiehstaller, S, Graf, S, Hennig, S. Deposit date: 2020-04-01 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
8A7N	Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125) Descriptor: N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, PHOSPHATE ION, T-box transcription factor T Authors: Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. Deposit date: 2022-06-21 Release date: 2022-10-05 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125) To Be Published
8A10	Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143 Descriptor: T-box transcription factor T, UNKNOWN LIGAND Authors: Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. Deposit date: 2022-05-30 Release date: 2022-07-13 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143 To Be Published
6YR6	14-3-3 sigma in complex with hDM2-186 peptide Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, ... Authors: Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. Deposit date: 2020-04-19 Release date: 2021-11-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR7	14-3-3 sigma in complex with hDMX-342+367 peptide Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 Authors: Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. Deposit date: 2020-04-19 Release date: 2021-11-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.105 Å) Cite: Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR5	14-3-3 sigma in complex with hDMX-367 peptide Descriptor: 14-3-3 protein sigma, Protein Mdm4, SULFATE ION Authors: Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A. Deposit date: 2020-04-19 Release date: 2021-11-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YW6	Cryo-EM structure of the ARP2/3 1B5CL isoform complex. Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ARPC1B, Actin-related protein 2, ... Authors: von Loeffelholz, O, Moores, C, Purkiss, A. Deposit date: 2020-04-29 Release date: 2020-07-22 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biol Open, 9, 2020
6YW7	Cryo-EM structure of the ARP2/3 1A5C isoform complex. Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... Authors: von Loeffelholz, O, Moores, C, Purkiss, A. Deposit date: 2020-04-29 Release date: 2020-07-22 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biol Open, 9, 2020
7ZMW	14-3-3s binding to non-natural peptide 2c Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 1 Authors: Somsen, B.A, Craenmehr, F.W.B, Ottmann, C. Deposit date: 2022-04-19 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022
7ZMU	14-3-3s binding to non-natural peptide 2d Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 2 Authors: Somsen, B.A, Craenmehr, F.W.B, Ottmann, C. Deposit date: 2022-04-19 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022
7ZJ3	Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate Descriptor: Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ... Authors: Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K. Deposit date: 2022-04-08 Release date: 2022-11-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity. Nat Commun, 13, 2022
8A5Q	Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of Chaetomium thermophilum INO80 on straight DNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin related protein 4 (Arp4), ... Authors: Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. Deposit date: 2022-06-15 Release date: 2022-12-14 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural mechanism of extranucleosomal DNA readout by the INO80 complex. Sci Adv, 8, 2022
8A5P	Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of Chaetomium thermophilum INO80 on curved DNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin related protein 4 (Arp4), ... Authors: Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. Deposit date: 2022-06-15 Release date: 2022-12-14 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural mechanism of extranucleosomal DNA readout by the INO80 complex. Sci Adv, 8, 2022
8A5D	Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of Chaetomium thermophilum INO80 Descriptor: Actin, Actin related protein 4 (Arp4), Actin-related protein 8, ... Authors: Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. Deposit date: 2022-06-14 Release date: 2022-12-28 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural mechanism of extranucleosomal DNA readout by the INO80 complex. Sci Adv, 8, 2022
8FMU	Crystal structure of human Brachyury G177D variant in complex with SJF-4601 Descriptor: N-(3-chloro-4-fluorophenyl)-3-[4-(dimethylamino)butanamido]-4-methoxybenzamide, T-box transcription factor T Authors: Bebenek, A, Linhares, B, Jaime-Figueroa, S, Butrin, A, Crews, C. Deposit date: 2022-12-24 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Discovery and Development of the First Selective Brachyury Degrader To Be Published
7ZTC	Non-muscle F-actin decorated with non-muscle tropomyosin 1.6 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 1.6, actin, ... Authors: Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. Deposit date: 2022-05-09 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms. Cell Rep, 42, 2023
7ZTD	Non-muscle F-actin decorated with non-muscle tropomyosin 3.2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 3.2, actin, ... Authors: Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. Deposit date: 2022-05-09 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms. Cell Rep, 42, 2023
5J9U	Crystal structure of the NuA4 core complex Descriptor: Chromatin modification-related protein EAF6, Chromatin modification-related protein YNG2, Enhancer of polycomb-like protein 1, ... Authors: Chen, Z.C, Xu, P. Deposit date: 2016-04-11 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (2.95 Å) Cite: The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism Mol.Cell, 63, 2016
7ZPC	CDK2 in complex 9K-DOS Descriptor: Cyclin-dependent kinase 2, ~{N}-(1-methylpyrazol-4-yl)-5-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxamide Authors: Watt, J.E, Martin, M.P, Noble, M.E.N. Deposit date: 2022-04-27 Release date: 2023-02-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity. J.Med.Chem., 65, 2022
6ZCJ	14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 Authors: Soini, L, Leysen, S, Davis, J, Ottmann, C. Deposit date: 2020-06-11 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.53 Å) Cite: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
5KC2	Negative stain structure of Vps15/Vps34 complex Descriptor: Phosphatidylinositol 3-kinase VPS34, Serine/threonine-protein kinase VPS15 Authors: Kirsten, M.L, Zhang, L, Ohashi, Y, Perisic, O, Williams, R.L, Sachse, C. Deposit date: 2016-06-04 Release date: 2016-10-05 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (28 Å) Cite: Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Autophagy, 12, 2016
2V4N	Crystal structure of Salmonella typhimurium SurE at 1.7 angstrom resolution in orthorhombic form Descriptor: GLYCEROL, MAGNESIUM ION, MULTIFUNCTIONAL PROTEIN SUR E, ... Authors: Anju, P, Savithri, H.S, Murthy, M.R.N. Deposit date: 2008-09-26 Release date: 2008-12-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and Functional Studies on a Mesophilic Stationary Phase Survival Protein (Sur E) from Salmonella Typhimurium FEBS J., 275, 2008

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