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3U47	Human Carbonic Anhydrase II V143L Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION Authors: West, D, Mckenna, R. Deposit date: 2011-10-07 Release date: 2012-10-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural modification of the hydrophobic pocket of Human Carbonic Anhydrase II To be Published
3TVO	Human Carbonic Anhydrase II Proton Transfer Double Mutant Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION Authors: Mikulski, R.M. Deposit date: 2011-09-20 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II. Biochemistry, 52, 2013
3RJ7	Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide Descriptor: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, MERCURIBENZOIC ACID, ... Authors: Spingler, B, Can, D, Alberto, R. Deposit date: 2011-04-15 Release date: 2012-02-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: [(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX. Angew.Chem.Int.Ed.Engl., 51, 2012
1G54	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,3,4,5,6-PENTAFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ... Authors: Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W. Deposit date: 2000-10-30 Release date: 2000-11-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II J.Am.Chem.Soc., 122, 2000
1FR7	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-07 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FLJ	CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III Descriptor: CARBONIC ANHYDRASE III, GLUTATHIONE, ZINC ION Authors: Mallis, R.J, Poland, B.W, Chatterjee, T.K, Fisher, R.A, Darmawan, S, Honzatko, R.B, Thomas, J.A. Deposit date: 2000-08-14 Release date: 2000-09-04 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of S-glutathiolated carbonic anhydrase III. FEBS Lett., 482, 2000
1FSR	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE II, COPPER (II) ION Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-11 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FQL	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-05 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1H4N	H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1HEB	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HEA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HCB	ENZYME-SUBSTRATE INTERACTIONS: STRUCTURE OF HUMAN CARBONIC ANHYDRASE I COMPLEXED WITH BICARBONATE Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE I, ZINC ION Authors: Kumar, V, Kannan, K.K. Deposit date: 1994-01-07 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Enzyme-substrate interactions. Structure of human carbonic anhydrase I complexed with bicarbonate. J.Mol.Biol., 241, 1994
1HEC	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1G0F	SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Duda, D, McKenna, R. Deposit date: 2000-10-06 Release date: 2000-10-18 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II. Biochemistry, 40, 2001
1G48	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,6-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ... Authors: Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W. Deposit date: 2000-10-26 Release date: 2000-11-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II J.Am.Chem.Soc., 122, 2000
1HCA	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-04-02 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II. J.Am.Chem.Soc., 113, 1991
1HED	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1FQM	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-06 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1H9Q	H119Q CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1H9N	H119N CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1FR4	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE II, COPPER (II) ION, SULFATE ION Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-07 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FSN	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE II Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-11 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FQR	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT Descriptor: CARBONIC ANHYDRASE, COBALT (II) ION Authors: Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. Deposit date: 2000-09-06 Release date: 2001-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1G1D	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2-FLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ... Authors: Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W. Deposit date: 2000-10-11 Release date: 2000-11-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Contribution of Fluorine to Protein-Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II J.Am.Chem.Soc., 122, 2000
1G4O	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-BENZYL-4-SULFAMOYL-BENZAMIDE, ... Authors: Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W. Deposit date: 2000-10-27 Release date: 2000-11-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II J.Am.Chem.Soc., 122, 2000

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