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6EP1	Transthyretin in complex with 5-(4-nitrophenylazo)-3-iodosalicylic acid Descriptor: 5-(4-nitrophenylazo)-3-iodosalicylic acid, Transthyretin Authors: Leite, J.P, Gales, L. Deposit date: 2017-10-10 Release date: 2018-10-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease Eur.J.Med.Chem., 2021
6E71	Structure of Human Transthyretin Val30Met/Thr119Met Mutant Descriptor: DI(HYDROXYETHYL)ETHER, Transthyretin Authors: Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural Variants of Transthyretin To Be Published
6E72	Structure of Human Transthyretin Val30Met Mutant in Complex with Tafamidis Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin Authors: Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2019-12-18 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural Variants of Transthyretin To Be Published
6E78	Structure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin Authors: Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2019-12-18 Method: X-RAY DIFFRACTION (1.499 Å) Cite: Structural Variants of Transthyretin To Be Published
6EOY	Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline Descriptor: 4-(1,3-benzothiazol-2-yl)-2-methyl-aniline, Transthyretin Authors: Leite, J.P, Gales, L. Deposit date: 2017-10-10 Release date: 2021-10-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. Eur.J.Med.Chem., 226, 2021
6FFT	Neutron structure of human transthyretin (TTR) S52P mutant in complex with tafamidis at room temperature to 2A resolution (quasi-Laue) Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin Authors: Yee, A.W, Moulin, M, Blakeley, M.P, Haertlein, M, Mitchell, E.P, Forsyth, V.T. Deposit date: 2018-01-09 Release date: 2019-01-02 Last modified: 2024-05-01 Method: NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION Cite: A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10, 2019
6FXU	Crystal structure of human transthyretin mutant T119M at pH 5.5 Descriptor: Transthyretin Authors: Varejao, N, Esperante, S, Ventura, S, Reverter, D. Deposit date: 2018-03-09 Release date: 2019-03-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.359 Å) Cite: Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297, 2021
6FZL	Crystal structure of human transthyretin double mutant K35T/T119M Descriptor: Transthyretin Authors: Esperante, S, Ventura, S, Reverter, D, Varejao, N. Deposit date: 2018-03-15 Release date: 2019-03-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.446 Å) Cite: Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297, 2021
6FTF	Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09 A resolution Descriptor: 1,2-ETHANEDIOL, 7-cyano-7-deazainosine, Protein kinase A regulatory subunit, ... Authors: Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. Deposit date: 2018-02-21 Release date: 2019-04-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.09151936 Å) Cite: Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun, 10, 2019
6E70	Structure of Wild Type Human Transthyretin in Complex with Diflunisal Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION, Transthyretin Authors: Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.992 Å) Cite: Structural Variants of Transthyretin To Be Published
6E76	Structure of Human Transthyretin Asp38Ala/Thr119Met Mutant Descriptor: ACETATE ION, GLYCEROL, SULFATE ION, ... Authors: Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2019-12-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Variants of Transthyretin To Be Published
6FWD	Crystal structure of human transthyretin double mutant R34G/T119M at pH 5.5 Descriptor: Transthyretin Authors: Esperante, S, Ventura, S, Reverter, D, Varejao, N. Deposit date: 2018-03-06 Release date: 2019-03-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.576 Å) Cite: Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297, 2021
6E75	Structure of Human Transthyretin Asp38Ala Mutant Descriptor: ACETATE ION, Transthyretin Authors: Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural Variants of Transthyretin To Be Published

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