6FZL
Crystal structure of human transthyretin double mutant K35T/T119M
Summary for 6FZL
| Entry DOI | 10.2210/pdb6fzl/pdb |
| Descriptor | Transthyretin (2 entities in total) |
| Functional Keywords | amyloid, gatekeeper, aggregation, stability, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 27558.75 |
| Authors | Esperante, S.,Ventura, S.,Reverter, D.,Varejao, N. (deposition date: 2018-03-15, release date: 2019-03-27, Last modification date: 2024-02-07) |
| Primary citation | Esperante, S.A.,Varejao, N.,Pinheiro, F.,Sant'Anna, R.,Luque-Ortega, J.R.,Alfonso, C.,Sora, V.,Papaleo, E.,Rivas, G.,Reverter, D.,Ventura, S. Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297:101039-101039, 2021 Cited by PubMed: 34343569DOI: 10.1016/j.jbc.2021.101039 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.446 Å) |
Structure validation
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