PDB: 19255 resultsInfo pagesStatus searchChemie searchBIRD

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4R4K	Crystal structure of a cystatin-like protein (BACCAC_01506) from Bacteroides caccae ATCC 43185 at 1.69 A resolution Descriptor: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, ACETATE ION, CHLORIDE ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-08-19 Release date: 2014-10-01 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Crystal structure of a hypothetical protein (BACCAC_01506) from Bacteroides caccae ATCC 43185 at 1.69 A resolution To be published
4R7S	Crystal structure of a tetratricopeptide repeat protein (PARMER_03812) from Parabacteroides merdae ATCC 43184 at 2.39 A resolution Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NITRATE ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-08-28 Release date: 2014-10-01 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Crystal structure of a tetratricopeptide repeat protein (PARMER_03812) from Parabacteroides merdae ATCC 43184 at 2.39 A resolution To be published
4R4V	Crystal structure of the VS ribozyme - G638A mutant Descriptor: MAGNESIUM ION, POTASSIUM ION, VS ribozyme RNA Authors: Piccirilli, J.A, Suslov, N.B, Dasgupta, S, Huang, H, Lilley, D.M.J, Rice, P.A. Deposit date: 2014-08-19 Release date: 2015-09-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.07 Å) Cite: Crystal structure of the Varkud satellite ribozyme. Nat.Chem.Biol., 11, 2015
4RKW	Crystal structure of DJ-1 Descriptor: Protein DJ-1 Authors: Liddington, R.C. Deposit date: 2014-10-14 Release date: 2015-08-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J.Neurosci., 34, 2014
4RLO	Human p70s6k1 with ruthenium-based inhibitor EM5 Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Domsic, J.F, Barber-Rotenberg, J, Salami, J, Qin, J, Marmorstein, R. Deposit date: 2014-10-17 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.527 Å) Cite: Development of Organometallic S6K1 Inhibitors. J.Med.Chem., 58, 2015
3TNQ	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein kinase, ... Authors: Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. Deposit date: 2011-09-01 Release date: 2012-02-01 Last modified: 2012-09-26 Method: X-RAY DIFFRACTION (3.097 Å) Cite: Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
4RVN	Crystal structure of a Putative Acyl-CoA ligase (BT_0428) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, COENZYME A, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-11-26 Release date: 2015-01-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of a Putative Acyl-CoA ligase (BT_0428) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution To be published
4RU2	Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution Descriptor: RNA-binding protein 39 (RBM39), Splicing factor U2AF 65 kDa subunit Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2014-11-17 Release date: 2015-02-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution To be published
4S31	Crystal structure of mitogen-activated protein kinase 1 wtERK2 at 1.45A Descriptor: Mitogen-activated protein kinase 1 Authors: Livnah, O, Karamansha, Y. Deposit date: 2015-01-26 Release date: 2016-01-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Multiple mechanisms render Erk proteins MEK-independent To be Published
3TNP	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit Authors: Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. Deposit date: 2011-09-01 Release date: 2012-02-01 Last modified: 2013-02-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
4PUC	Crystal structure of a SusD homolog (BACUNI_02643) from Bacteroides uniformis ATCC 8492 at 2.00 A resolution Descriptor: ACETATE ION, SusD homolog, ZINC ION Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-03-12 Release date: 2014-06-04 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a SusD homolog (BACUNI_02643) from Bacteroides uniformis ATCC 8492 at 2.00 A resolution To be published
4PV7	Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor Descriptor: 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine, Dipeptidyl peptidase 4 soluble form Authors: Xiao, P, Guo, R, Huang, S, Cui, H, Ye, S, Zhang, Z. Deposit date: 2014-03-15 Release date: 2015-03-18 Method: X-RAY DIFFRACTION (3.24 Å) Cite: Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold Chin.Chem.Lett., 25, 2014
4PNZ	Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102) Descriptor: (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Yan, Y. Deposit date: 2014-02-22 Release date: 2014-04-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes. J.Med.Chem., 57, 2014
4P9T	Structure of the free form of the N-terminal VH1 domain of monomeric alpha-catenin Descriptor: 1,2-ETHANEDIOL, Catenin alpha-2, DI(HYDROXYETHYL)ETHER, ... Authors: Shibahara, T, Hirano, Y, Hakoshima, T. Deposit date: 2014-04-04 Release date: 2015-04-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the free form of the N-terminal VH1 domain of monomeric alpha-catenin. Febs Lett., 589, 2015
4PXF	Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1 Descriptor: ACETATE ION, PALMITIC ACID, Rhodopsin, ... Authors: Szczepek, M, Scheerer, P. Deposit date: 2014-03-23 Release date: 2014-09-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structure of a common GPCR-binding interface for G protein and arrestin. Nat Commun, 5, 2014
4Q08	Crystal structure of chimeric carbonic anhydrase XII with inhibitor Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, BICINE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-04-01 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4PXT	Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers Descriptor: Bipolar kinesin KRP-130 Authors: Scholey, J.E, Nithianantham, S, Scholey, J.M, Al-Bassam, J. Deposit date: 2014-03-25 Release date: 2014-04-23 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife, 3, 2014
4Q5O	Crystal structure of EctD from S. alaskensis with 2-oxoglutarate and 5-hydroxyectoine Descriptor: (4S,5S)-5-HYDROXY-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 2-OXOGLUTARIC ACID, Ectoine hydroxylase, ... Authors: Hoeppner, A, Widderich, N, Bremer, E, Smits, S.H. Deposit date: 2014-04-17 Release date: 2014-09-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
4Q0L	Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor Descriptor: 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 12, ZINC ION Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-04-02 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4PZH	Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide Descriptor: 1,2-ETHANEDIOL, 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-03-31 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.06 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4S1G	Renin in complex with (S)-1-(3-fluoro-5-(((S)-1-phenylethyl)carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{[(4S)-2-amino-4-methyl-6-oxo-4-(propan-2-yl)-5,6-dihydropyrimidin-1(4H)-yl]methyl}-5-fluoro-N-[(1S)-1-phenylethyl]benzamide, Renin Authors: Orth, P. Deposit date: 2015-01-13 Release date: 2015-02-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
3TUF	Structure of the SpoIIQ-SpoIIIAH pore forming complex. Descriptor: Stage II sporulation protein Q, Stage III sporulation protein AH Authors: Levdikov, V.M, Blagova, E.V, Wilkinson, A.J. Deposit date: 2011-09-16 Release date: 2012-03-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structure of components of an intercellular channel complex in sporulating Bacillus subtilis. Proc.Natl.Acad.Sci.USA, 109, 2012
4S0Z	Crystal structure of M26V human DJ-1 Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Protein DJ-1 Authors: Milkovic, N.M, Wilson, M.A. Deposit date: 2015-01-07 Release date: 2015-08-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature. Protein Sci., 24, 2015
4RWV	Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution Descriptor: (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology, Partnership for Stem Cell Biology (STEMCELL) Deposit date: 2014-12-05 Release date: 2015-01-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.859 Å) Cite: Crystal structure of a Homo sapiens hepatocytic transcription factor hB1F-2 (B1F2) in complex with nuclear receptor subfamily 0 group B member 1 (NR0B1, residues 140-154) from human at 1.86 A resolution To be published
4S2Z	ERK2 Intrinsically active mutant R65S Descriptor: Mitogen-activated protein kinase 1 Authors: Livnah, O, Karamansha, Y. Deposit date: 2015-01-25 Release date: 2016-01-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Multiple mechanisms render Erk proteins MEK-independent To be Published

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