Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution

Summary for 4RWV

DescriptorNuclear receptor subfamily 5 group A member 2, Nuclear receptor DAX1, (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, ... (6 entities in total)
Functional Keywordsligand-binding domain of nuclear hormone receptor, pf00104 family, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-biology, partnership for stem cell biology, transcription, stemcell
Biological sourceHomo sapiens (human)
Cellular locationNucleus  O00482 F1D8P4
Total number of polymer chains2
Total molecular weight31868.46
Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology,Partnership for Stem Cell Biology (STEMCELL) (deposition date: 2014-12-05, release date: 2015-01-21, Last modification date: 2018-01-24)
Primary citation
Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology
Crystal structure of a Homo sapiens hepatocytic transcription factor hB1F-2 (B1F2) in complex with nuclear receptor subfamily 0 group B member 1 (NR0B1, residues 140-154) from human at 1.86 A resolution
To be published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210700.4%8.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload