4RWV
Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor subfamily 5 group A member 2 | polymer | 249 | 28733.1 | 1 | UniProt (O00482) Pfam (PF00104) | Homo sapiens (human) | Alpha-1-fetoprotein transcription factor, B1-binding factor, hB1F, CYP7A promoter-binding factor, Hepatocytic transcription factor, Liver receptor homolog 1, LRH-1 |
| 2 | B (B) | Nuclear receptor DAX1 | polymer | 15 | 1651.9 | 1 | UniProt (F1D8P4) UniProt (by SIFTS) (P51843) | Homo sapiens | Nuclear receptor subfamily 0, group B, member 1 |
| 3 | C (A) | (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate | non-polymer | 1051.0 | 1 | Chemie (PIZ) | |||
| 4 | D, E, F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | I (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
A: 294 - 541 (UniProt: O00482)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30385.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1483.5 | |
| All* | Total formula weight | 31868.5 |
