4RWV
Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE PIZ A 601 |
| Chain | Residue |
| A | PHE342 |
| A | TYR516 |
| A | LYS520 |
| A | HIS537 |
| A | HOH716 |
| A | HOH737 |
| A | HOH765 |
| A | HOH771 |
| A | HOH779 |
| A | HOH780 |
| A | HOH882 |
| A | ILE416 |
| A | HOH891 |
| A | HOH892 |
| A | HOH893 |
| B | PRO140 |
| B | ARG141 |
| A | GLN419 |
| A | ALA420 |
| A | GLY421 |
| A | ALA422 |
| A | THR423 |
| A | LEU424 |
| A | ALA513 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 602 |
| Chain | Residue |
| A | MET323 |
| A | LEU326 |
| A | GLN409 |
| A | TYR518 |
| A | TYR519 |
| A | LEU522 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 603 |
| Chain | Residue |
| A | ASN426 |
| A | HIS430 |
| A | ALA508 |
| A | GLN512 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 604 |
| Chain | Residue |
| A | PRO298 |
| A | ASP444 |
| A | ARG446 |
| A | TYR489 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 605 |
| Chain | Residue |
| A | LYS370 |
| A | ASP372 |
| A | SER429 |
| A | HIS430 |
| A | HOH741 |
| A | HOH910 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 606 |
| Chain | Residue |
| A | GLN474 |
| A | ASN478 |
| A | LEU503 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS B 201 |
| Chain | Residue |
| A | HOH834 |
| B | PRO140 |
| B | ARG141 |
| B | GLN142 |
| B | SER144 |
| B | TYR147 |
| B | HOH303 |
| B | HOH305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15897460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22187462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22504882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26416531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26553876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RWV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LXXLL motif 3"} |
| Chain | Residue | Details |
