4PXF

Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1

Summary for 4PXF

DescriptorRhodopsin, S-arrestin, N-ACETYL-D-GLUCOSAMINE, ... (11 entities in total)
Functional Keywordsretinal protein, photoreceptor, g-protein coupled receptor, phosphoprotein, photoreceptor protein, sensory transduction, transducer, transmembrane, vision, signaling protein, visual arrestin, desensitisation of the visual transduction cascade, binding to acticated and phosphorylated rhodopsin, rhodopsin, opsin
Biological sourceBos taurus (Bovine)
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Cellular locationMembrane; Multi-pass membrane protein P02699
Total number of polymer chains2
Total molecular weight42704.47
Authors
Szczepek, M.,Scheerer, P. (deposition date: 2014-03-23, release date: 2014-09-17)
Primary citation
Szczepek, M.,Beyriere, F.,Hofmann, K.P.,Elgeti, M.,Kazmin, R.,Rose, A.,Bartl, F.J.,von Stetten, D.,Heck, M.,Sommer, M.E.,Hildebrand, P.W.,Scheerer, P.
Crystal structure of a common GPCR-binding interface for G protein and arrestin.
Nat Commun, 5:4801-4801, 2014
PubMed: 25205354 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms5801
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25970.3%0.7%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4pxf.pdb1.gz [247 KB])