8HOB
 
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2Z14
 | | Crystal structure of the N-terminal DUF1126 in human ef-hand domain containing 2 protein | | Descriptor: | EF-hand domain-containing family member C2 | | Authors: | Saito, K, Olsen, S, Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Crystal structure of the N-terminal DUF1126 in human ef-hand domain containing 2 protein
To be Published
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1UCF
 | | The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease | | Descriptor: | RNA-binding protein regulatory subunit | | Authors: | Honbou, K, Suzuki, N.N, Horiuchi, M, Niki, T, Taira, T, Ariga, H, Inagaki, F. | | Deposit date: | 2003-04-11 | | Release date: | 2003-08-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease
J.BIOL.CHEM., 278, 2003
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1IP9
 | | SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P | | Descriptor: | BEM1 PROTEIN | | Authors: | Terasawa, H, Noda, Y, Ito, T, Hatanaka, H, Ichikawa, S, Ogura, K, Sumimoto, H, Inagaki, F. | | Deposit date: | 2001-04-26 | | Release date: | 2001-08-15 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif.
EMBO J., 20, 2001
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3QQV
 | | Crystal structure of geranylgeranyl pyrophosphate synthase from corynebacterium glutamicum complexed with isoprenyl diphosphate and magnesium | | Descriptor: | DIMETHYLALLYL DIPHOSPHATE, GLYCEROL, Geranylgeranyl pyrophosphate synthase, ... | | Authors: | Patskovsky, Y, Toro, R, Sauder, J.M, Poulter, C.D, Gerlt, J.A, Burley, S.K, Almo, S.C, Enzyme Function Initiative (EFI), New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2011-02-16 | | Release date: | 2011-03-02 | | Last modified: | 2021-02-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5EY9
 | | Structure of FadD32 from Mycobacterium marinum complexed to AMPC12 | | Descriptor: | GLYCEROL, Long-chain-fatty-acid--AMP ligase FadD32, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl icosyl hydrogen phosphate | | Authors: | Guillet, V, Maveyraud, L, Mourey, L. | | Deposit date: | 2015-11-24 | | Release date: | 2015-12-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
J.Biol.Chem., 291, 2016
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3NYU
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5O51
 | | AfRom2 CNH domain | | Descriptor: | Rho guanyl nucleotide exchange factor (Rom2), putative | | Authors: | Wei, W, van Aalten, D. | | Deposit date: | 2017-05-31 | | Release date: | 2018-06-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Rom2 CNH domain from Aspergillus fumigatus is an atypical seven-bladed WD-40 protein
To Be Published
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1JD3
 | | Chorismate lyase G90A mutant with bound product | | Descriptor: | P-HYDROXYBENZOIC ACID, chorismate lyase | | Authors: | Mayhew, M, Smith, N, Holden, M.J, Gallagher, D.T. | | Deposit date: | 2001-06-12 | | Release date: | 2001-06-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structural analysis of ligand binding and catalysis in chorismate lyase.
Arch.Biochem.Biophys., 445, 2006
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8PTE
 | | Polyoxidovanadate interaction with proteins: crystal structure of lysozyme bound to octadecavanadate ion (structure B) | | Descriptor: | Lysozyme C, NITRATE ION, Polyoxidovanadate complex, ... | | Authors: | Tito, G, Ferraro, G, Merlino, A. | | Deposit date: | 2023-07-14 | | Release date: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.797 Å) | | Cite: | Stabilization and Binding of [V 4 O 12 ] 4- and Unprecedented [V 20 O 54 (NO 3 )] n- to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V IV O(acetylacetonato) 2.
Angew.Chem.Int.Ed.Engl., 62, 2023
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1K5S
 | | PENICILLIN ACYLASE, MUTANT COMPLEXED WITH PPA | | Descriptor: | CALCIUM ION, PENICILLIN G ACYLASE ALPHA SUBUNIT, PENICILLIN G ACYLASE BETA SUBUNIT, ... | | Authors: | Hensgens, C.M.H, Keizer, E, Snijder, H.J, Dijkstra, B.W. | | Deposit date: | 2001-10-12 | | Release date: | 2003-09-02 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
Protein Eng.Des.Sel., 17, 2004
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4QIR
 | | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-2-(pyridin-3-yl)ethylGlyP[CH2]Phe | | Descriptor: | 3-{[(R)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(S)-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... | | Authors: | Nocek, B, Joachimiak, A, Berlicki, L, Vassiliou, S, Mucha, A. | | Deposit date: | 2014-06-01 | | Release date: | 2014-09-24 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.701 Å) | | Cite: | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.
J.Med.Chem., 57, 2014
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1KCG
 | | NKG2D in complex with ULBP3 | | Descriptor: | GLUTATHIONE, NKG2-D type II integral membrane protein, ULBP3 protein | | Authors: | Radaev, S, Sun, P. | | Deposit date: | 2001-11-08 | | Release date: | 2002-01-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.
Immunity, 15, 2001
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4QHP
 | | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2) | | Descriptor: | (2R)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, (2S)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, Aminopeptidase N, ... | | Authors: | Nocek, B, Joachimiak, A. | | Deposit date: | 2014-05-28 | | Release date: | 2014-09-24 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.
J.Med.Chem., 57, 2014
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2BKM
 | | Crystal structure of the truncated hemoglobin from Geobacillus stearothermophilus | | Descriptor: | ACETATE ION, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Ilari, A, Kjelgaard, P, von Wachenfeldt, C, Boffi, A, Chiancone, E. | | Deposit date: | 2006-02-08 | | Release date: | 2006-11-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure and Ligand Binding Properties of the Truncated Hemoglobin from Geobacillus Stearothermophilus
Arch.Biochem.Biophys., 457, 2007
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5V1A
 | | Structure of S. cerevisiae Ulp2:Csm1 complex | | Descriptor: | Monopolin complex subunit CSM1, Ubiquitin-like-specific protease 2 | | Authors: | Singh, N, Corbett, K.D. | | Deposit date: | 2017-03-01 | | Release date: | 2017-05-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity.
Genes Dev., 31, 2017
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6N13
 | | UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin | | Descriptor: | E3 ubiquitin-protein ligase parkin, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ... | | Authors: | Condos, T.E.C, Dunkerley, K.M, Freeman, E.A, Barber, K.R, Aguirre, J.D, Chaugule, V.K, Xiao, Y, Konermann, L, Walden, H, Shaw, G.S. | | Deposit date: | 2018-11-08 | | Release date: | 2018-11-28 | | Last modified: | 2020-01-08 | | Method: | SOLUTION NMR | | Cite: | Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
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1JE6
 | | Structure of the MHC Class I Homolog MICB | | Descriptor: | MHC class I chain-related protein, SULFATE ION | | Authors: | Holmes, M.A, Li, P, Strong, R.K. | | Deposit date: | 2001-06-15 | | Release date: | 2002-08-07 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.
J.Immunol., 169, 2002
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1DZ8
 | | oxygen complex of p450cam from pseudomonas putida | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ... | | Authors: | Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G. | | Deposit date: | 2000-02-18 | | Release date: | 2000-03-31 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
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1U3N
 | | A SOD-like protein from B. subtilis, unstructured in solution, becomes ordered in the crystal: implications for function and for fibrillogenesis | | Descriptor: | Hypothetical superoxide dismutase-like protein yojM | | Authors: | Banci, L, Bertini, I, Calderone, V, Cramaro, F, Del Conte, R, Fantoni, A, Mangani, S, Quattrone, A, Viezzoli, M.S. | | Deposit date: | 2004-07-22 | | Release date: | 2005-05-03 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | A prokaryotic superoxide dismutase paralog lacking two Cu ligands: from largely unstructured in solution to ordered in the crystal.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1S4I
 | | Crystal structure of a SOD-like protein from Bacillus subtilis | | Descriptor: | CHLORIDE ION, ZINC ION, superoxide dismutase-like protein yojM | | Authors: | Banci, L, Bertini, I, Calderone, V, Cramaro, F, Del Conte, R, Fantoni, A, Mangani, S, Quattrone, A, Viezzoli, M.S. | | Deposit date: | 2004-01-16 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A prokaryotic superoxide dismutase paralog lacking two Cu ligands: from largely unstructured in solution to ordered in the crystal.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1ZAF
 | | Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one | | Descriptor: | 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE, Estrogen receptor beta, Nuclear receptor coactivator 1 | | Authors: | McDevitt, R.E, Malamas, M.S, Manas, E.S, Unwalla, R.J, Xu, Z.B, Miller, C.P, Harris, H.A. | | Deposit date: | 2005-04-06 | | Release date: | 2006-04-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones
Bioorg.Med.Chem.Lett., 15, 2005
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3N8H
 | | Crystal Structure of Pantoate-beta-alanine Ligase from Francisella tularensis | | Descriptor: | ACETIC ACID, ADENOSINE MONOPHOSPHATE, GLYCEROL, ... | | Authors: | Maltseva, N, Kim, Y, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2010-05-28 | | Release date: | 2010-06-16 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Crystal Structure of Pantoate-beta-alanine Ligase from Francisella tularensis
To be Published, 2010
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7U3E
 | | GID4 in complex with compound 1 | | Descriptor: | Glucose-induced degradation protein 4 homolog, tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | | Authors: | Chana, C.K, Sicheri, F. | | Deposit date: | 2022-02-27 | | Release date: | 2022-10-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.852 Å) | | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
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7U3F
 | | GID4 in complex with compound 4 | | Descriptor: | (4R)-4-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine, GLYCEROL, Glucose-induced degradation protein 4 homolog | | Authors: | Chana, C.K, Sicheri, F. | | Deposit date: | 2022-02-27 | | Release date: | 2022-10-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
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