5HJQ
| Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, LD10117p | Authors: | Fischer, B, Paesmans, J, Versees, W. | Deposit date: | 2016-01-13 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function. Nat.Struct.Mol.Biol., 23, 2016
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5IH5
| Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A | Descriptor: | 6-(3-chlorophenyl)pteridine-2,4,7-triamine, Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, ... | Authors: | Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H. | Deposit date: | 2016-02-29 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol, 23, 2016
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5IH4
| Human Casein Kinase 1 isoform delta apo (kinase domain) | Descriptor: | Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, SULFATE ION, ... | Authors: | Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H. | Deposit date: | 2016-02-29 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol, 23, 2016
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5IH6
| Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative | Descriptor: | 6-(3-bromophenyl)pteridine-2,4,7-triamine, Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, ... | Authors: | Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H. | Deposit date: | 2016-02-29 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol, 23, 2016
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7GQT
| Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ... | Authors: | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | Deposit date: | 2023-10-19 | Release date: | 2024-05-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7GQU
| Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ... | Authors: | Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G. | Deposit date: | 2023-10-19 | Release date: | 2024-05-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7GQS
| Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | Authors: | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | Deposit date: | 2023-10-19 | Release date: | 2024-05-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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2PSE
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7KAT
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore ring and Sec63 FN3 double mutant, class without Sec62 | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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5JG4
| Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila | Descriptor: | CITRATE ANION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Beyrakhova, K, van Straaten, K, Cygler, M. | Deposit date: | 2016-04-19 | Release date: | 2016-05-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila. J.Biol.Chem., 291, 2016
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7KAO
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class without Sec62 | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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5HJN
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7KAQ
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class with Sec62, conformation 2 (C2) | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAJ
| Cryo-EM structure of the Sec complex from S. cerevisiae, wild-type, class with Sec62, conformation 2 (C2) | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7JOT
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2PSF
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7KAS
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec63 FN3 mutant, class with Sec62 | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAH
| Cryo-EM structure of the Sec complex from S. cerevisiae, wild-type, class without Sec62 | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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2PSH
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7KAI
| Cryo-EM structure of the Sec complex from S. cerevisiae, wild-type, class with Sec62, conformation 1 (C1) | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAR
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec63 FN3 mutant, class without Sec62 | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAU
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore ring and Sec63 FN3 double mutant, class with Sec62 | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAP
| Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class with Sec62, conformation 1 (C1) | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KB5
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2PSJ
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