1URL
 
 | | N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE | | Descriptor: | ALA-GLY-HIS-THR-TRP-GLY-HIA, N-acetyl-alpha-neuraminic acid, SIALOADHESIN | | Authors: | Bukrinsky, J.T, Hilaire, P.M.S, Meldal, M, Crocker, P.R, Henriksen, A. | | Deposit date: | 2003-10-31 | | Release date: | 2004-10-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Complex of Sialoadhesin with a Glycopeptide Ligand
Biochim.Biophys.Acta, 1702, 2004
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1N7P
 | | Streptococcus pneumoniae Hyaluronate Lyase W292A/F343V Double Mutant | | Descriptor: | HYALURONIDASE | | Authors: | Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J. | | Deposit date: | 2002-11-16 | | Release date: | 2002-12-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The function of hydrophobic residues in the catalytic cleft of Streptococcus
pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
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1N7N
 | | Streptococcus pneumoniae Hyaluronate Lyase W292A Mutant | | Descriptor: | HYALURONIDASE | | Authors: | Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J. | | Deposit date: | 2002-11-16 | | Release date: | 2002-12-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The function of hydrophobic residues in the catalytic cleft of Streptococcus
pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
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1N7O
 | | Streptococcus pneumoniae Hyaluronate Lyase F343V Mutant | | Descriptor: | hyaluronidase | | Authors: | Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J. | | Deposit date: | 2002-11-16 | | Release date: | 2002-12-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The function of hydrophobic residues in the catalytic cleft of Streptococcus
pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
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3ZJH
 | | Trp(60)B9Ala mutation of M.acetivorans protoglobin in complex with cyanide | | Descriptor: | CYANIDE ION, PROTOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Pesce, A, Tilleman, L, Donne, J, Aste, E, Ascenzi, P, Ciaccio, C, Coletta, M, Moens, L, Viappiani, C, Dewilde, S, Bolognesi, M, Nardini, M. | | Deposit date: | 2013-01-18 | | Release date: | 2013-06-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure and Haem-Distal Site Plasticity in Methanosarcina Acetivorans Protoglobin.
Plos One, 8, 2013
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1F9G
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1M02
 | | NMR Structure of PW2 Bound to SDS Micelles: A Tryptophan-rich Anticocidial Peptide Selected from Phage Display Libraries | | Descriptor: | HIS-PRO-LEU-LYS-GLN-TYR-TRP-TRP-ARG-PRO-SER-ILE | | Authors: | Tinoco, L.W, da Silva Jr, A, Leite, A, Valente, A.P, Almeida, F.C. | | Deposit date: | 2002-06-11 | | Release date: | 2002-08-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries
J.Biol.Chem., 277, 2002
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6XOY
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6XRH
 | | Salmonella typhimurium tryptophan synthase complexed with oxindolyl-L-alanine and D-glycerol-3-phosphate | | Descriptor: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]-L-alanine, 4-[(E)-({1-carboxy-2-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]ethan-1-id-1-yl}iminio)methyl]-2-methyl-5-[(phosphonooxy)methyl]pyridin-1-ium-3-olate, DIMETHYL SULFOXIDE, ... | | Authors: | Phillips, R.S. | | Deposit date: | 2020-07-12 | | Release date: | 2021-02-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Structural Basis of the Stereochemistry of Inhibition of Tryptophan Synthase by Tryptophan and Derivatives.
Biochemistry, 60, 2021
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6XT0
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6XNC
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6XAK
 | | Crystal structure of NzeB in complex with cyclo-(L-Trp-L-Pro) and cyclo-(L-Trp-L-Trp) | | Descriptor: | (3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione, (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, 1,2-ETHANEDIOL, ... | | Authors: | Shende, V.V, Khatri, Y, Newmister, S.A, Sanders, J.N, Lindovska, P, Yu, F, Doyon, T.J, Kim, J, Movassaghi, M, Houk, K.N, Sherman, D.H. | | Deposit date: | 2020-06-04 | | Release date: | 2021-06-09 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.479 Å) | | Cite: | Structure and Function of NzeB, a Versatile C-C and C-N Bond-Forming Diketopiperazine Dimerase.
J.Am.Chem.Soc., 142, 2020
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3KT6
 | | Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase in complex with Trp | | Descriptor: | SULFATE ION, TRYPTOPHAN, Tryptophanyl-tRNA synthetase, ... | | Authors: | Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. | | Deposit date: | 2009-11-24 | | Release date: | 2010-02-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design
Nucleic Acids Res., 38, 2010
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7W8Y
 | | DMSPP- and Naplha-Me-Trp-bound 6-dimethylallyl tryptophan synthase, IptA | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-dimethylallyltryptophan synthase, ... | | Authors: | Suemune, H, Nagano, S. | | Deposit date: | 2021-12-08 | | Release date: | 2022-10-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.
Biochem.Biophys.Res.Commun., 593, 2022
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7W8V
 | | DMSPP- and Trp-bound 6-dimethylallyl tryptophan synthase, IptA | | Descriptor: | 6-dimethylallyltryptophan synthase, DIMETHYLALLYL S-THIOLODIPHOSPHATE, SULFATE ION, ... | | Authors: | Suemune, H, Nagano, S, Tomoya, H. | | Deposit date: | 2021-12-08 | | Release date: | 2022-10-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.
Biochem.Biophys.Res.Commun., 593, 2022
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7W8X
 | | DMSPP- and 6-Me-Trp-bound dimethylallyl tryptophan synthase, IptA | | Descriptor: | (2S)-2-azanyl-3-(6-methyl-1H-indol-3-yl)propanoic acid, 6-dimethylallyltryptophan synthase, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ... | | Authors: | Suemune, H, Nagano, S, Tomoya, H. | | Deposit date: | 2021-12-08 | | Release date: | 2022-10-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.
Biochem.Biophys.Res.Commun., 593, 2022
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7W8W
 | | DMSPP- and 5-Me-Trp-bound 6-dimethylallyl tryptophan synthase, IptA | | Descriptor: | 5-methyl-L-tryptophan, 6-dimethylallyltryptophan synthase, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ... | | Authors: | Suemune, H, Nagano, S, Tomoya, H. | | Deposit date: | 2021-12-08 | | Release date: | 2022-10-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.
Biochem.Biophys.Res.Commun., 593, 2022
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5TIA
 | | Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161 | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, Tryptophan 2,3-dioxygenase | | Authors: | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | | Deposit date: | 2016-10-01 | | Release date: | 2016-10-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.441 Å) | | Cite: | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Sci Rep, 6, 2016
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5TI9
 | | Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161 | | Descriptor: | N'-Formylkynurenine, OXYGEN MOLECULE, PHOSPHATE ION, ... | | Authors: | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | | Deposit date: | 2016-10-01 | | Release date: | 2016-10-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Sci Rep, 6, 2016
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8AD7
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7DTV
 | | Human Calcium-Sensing Receptor bound with L-Trp and calcium ions | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | | Deposit date: | 2021-01-06 | | Release date: | 2021-03-10 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan.
Cell Res., 31, 2021
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2QUH
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7DTU
 | | Human Calcium-Sensing Receptor bound with L-Trp | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular calcium-sensing receptor, ... | | Authors: | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | | Deposit date: | 2021-01-06 | | Release date: | 2021-03-10 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan.
Cell Res., 31, 2021
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9CLC
 | | Crystal structure of maltose binding protein (Apo), mutant Trp10 to 4-Cyanotryptophan | | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Habel, E, Frkic, R.L, Jackson, C.J, Huber, T, Otting, G. | | Deposit date: | 2024-07-10 | | Release date: | 2024-12-18 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4-Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites.
Angew.Chem.Int.Ed.Engl., 64, 2025
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2A4M
 | | Structure of Trprs II bound to ATP | | Descriptor: | TRYPTOPHAN, Tryptophanyl-tRNA synthetase II | | Authors: | Buddha, M.R, Crane, B.R. | | Deposit date: | 2005-06-29 | | Release date: | 2005-08-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of Tryptophanyl-tRNA Synthetase II from Deinococcus radiodurans Bound to ATP and Tryptophan: Insight into subunit cooperativity and domain motions linked to catalysis
J.Biol.Chem., 280, 2005
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