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5DH9	Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
4GK0	Crystal structure of human Rev3-Rev7-Rev1 complex Descriptor: DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Tao, J, Min, X, Wei, X. Deposit date: 2012-08-10 Release date: 2013-03-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
4GMX	Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-16 Release date: 2012-10-17 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120, 2012
4FWS	Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with CTP Descriptor: 1,2-ETHANEDIOL, CYTIDINE-5'-TRIPHOSPHATE, Propionate kinase Authors: Chittori, S, Savithri, H.S, Murthy, M.R.N. Deposit date: 2012-07-01 Release date: 2013-06-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
4GK5	Crystal structure of human Rev3-Rev7-Rev1-Polkappa complex Descriptor: DNA polymerase kappa, DNA polymerase zeta catalytic subunit, DNA repair protein REV1, ... Authors: Tao, J, Min, X, Wei, X. Deposit date: 2012-08-10 Release date: 2013-03-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
6Z3R	Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... Authors: Langer, L.M, Gat, Y, Conti, E. Deposit date: 2020-05-21 Release date: 2020-06-24 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife, 9, 2020
4HAW	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
5D7E	Crystal structure of Taf14 YEATS domain in complex with H3K9ac Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, H3K9ac, ... Authors: Andrews, F.H, Shanle, E.K, Strahl, B.D, Kutateladze, T.G. Deposit date: 2015-08-13 Release date: 2015-09-23 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Genes Dev., 29, 2015
5DHA	Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIF	Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
4H0W	Bismuth bound human serum transferrin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Bismuth(III) ION, CARBONATE ION, ... Authors: Yang, N, Zhang, H, Wang, M, Hao, Q, Sun, H. Deposit date: 2012-09-10 Release date: 2012-12-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep, 2, 2012
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
4HB3	Crystal structure of CRM1(T539S)-Ran-RanBP1 with weakly bound unmodeled Leptomycin B Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
5A17	The structure of the SOLE element of oskar mRNA Descriptor: OSKAR MRNA Authors: Simon, B, Masiewicz, P, Ephrussi, A, Carlomagno, T. Deposit date: 2015-04-28 Release date: 2015-05-06 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: The Structure of the Sole Element of Oskar Mrna. RNA, 21, 2015
5A2P	THE COMPLEX STRUCTURE OF PDZ DOMAINS IN SYNTENIN-1 WITH 4L PEPTIDE Descriptor: SYNDECAN-4, SYNTENIN-1 Authors: Yoo, J.H, Yun, J.H, Cho, H.S, Lee, W. Deposit date: 2015-05-21 Release date: 2016-06-01 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.496 Å) Cite: Titl the Complex Structure of Pdz Domains in Syntenin-1 with 4L Peptide To be Published
4HAY	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548E,K579Q)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
2CDT	alpha-SPECTRIN SH3 DOMAIN A56S MUTANT Descriptor: SPECTRIN ALPHA CHAIN Authors: Casares, S, Camara-Artigas, A, Vega, M.C, Lopez-Mayorga, O, Conejero-Lara, F. Deposit date: 2006-01-27 Release date: 2007-02-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Cooperative Propagation of Local Stability Changes from Low-Stability and High-Stability Regions in a SH3 Domain. Proteins: Struct., Funct., Bioinf., 67, 2007
4HAT	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
5EC7	Crystal structure of a chimeric c-Src-SH3 domain with the sequence of the RT-loop from the Abl-SH3 domain at pH 5.0 Descriptor: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2015-10-20 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of a chimeric c-Src-SH3 domain with the sequence of the RT-loop from the Abl-SH3 domain at pH 5.0 to be published
4F7G	Crystal structure of talin autoinhibition complex Descriptor: Talin-1 Authors: Song, X, Qin, J, Ye, S, Zhang, R. Deposit date: 2012-05-16 Release date: 2012-07-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Res., 22, 2012
5E0M	LC8 - Chica (468-476) Complex Descriptor: Dynein light chain 1, cytoplasmic, Protein Chica peptide, ... Authors: Clark, S.A, Barbar, E.B, Karplus, P.A. Deposit date: 2015-09-29 Release date: 2015-12-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: The Anchored Flexibility Model in LC8 Motif Recognition: Insights from the Chica Complex. Biochemistry, 55, 2016
4GPT	Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-21 Release date: 2012-09-05 Last modified: 2013-01-23 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, 27, 2013
4FWK	Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with AMP Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Propionate kinase Authors: Chittori, S, Savithri, H.S, Murthy, M.R.N. Deposit date: 2012-07-01 Release date: 2013-06-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013

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