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3SR4	Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor Descriptor: (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ACETATE ION, GLYCEROL, ... Authors: Diao, J, Chen, P, Yao, Y, Prasad, B.V.V, Song, Y. Deposit date: 2011-07-06 Release date: 2011-10-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies. J.Am.Chem.Soc., 133, 2011
6SEG	Class1: CENP-A nucleosome in complex with CENP-C central region Descriptor: DNA (145-MER), Histone H2A type 2-A, Histone H2B type 1-C/E/F/G/I, ... Authors: Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. Deposit date: 2019-07-30 Release date: 2019-08-14 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
6SE0	Class 1 : CENP-A nucleosome Descriptor: DNA (145-MER), Histone H2A type 2-A, Histone H2B type 1-C/E/F/G/I, ... Authors: Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. Deposit date: 2019-07-29 Release date: 2019-08-14 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
6SE6	Class2 : CENP-A nucleosome in complex with CENP-C central region Descriptor: Centromere protein C, DNA (145-MER), Histone H2A type 2-A, ... Authors: Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. Deposit date: 2019-07-29 Release date: 2019-08-14 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
6SEE	Class2A : CENP-A nucleosome in complex with CENP-C central region Descriptor: Centromere protein C, DNA (145-MER), Histone H2A type 2-A, ... Authors: Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. Deposit date: 2019-07-29 Release date: 2019-08-14 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
2X4X	Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1. Descriptor: HISTONE H3.2, PEREGRIN, SULFATE ION Authors: Vezzoli, A, Bonadies, N, Allen, M.D, Freund, S.M.V, Santiveri, C.M, Kvinlaug, B, Huntly, B.J.P, Gottgens, B, Bycroft, M. Deposit date: 2010-02-02 Release date: 2010-04-21 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Molecular Basis of Histone H3K36Me3 Recognition by the Pwwp Domain of Brpf1. Nat.Struct.Mol.Biol., 17, 2010
2X4W	Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1. Descriptor: FORMIC ACID, HISTONE H3.2, PEREGRIN Authors: Vezzoli, A, Bonadies, N, Allen, M.D, Freund, S.M.V, Santiveri, C.M, Kvinlaug, B, Huntly, B.J.P, Gottgens, B, Bycroft, M. Deposit date: 2010-02-02 Release date: 2010-04-21 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Molecular Basis of Histone H3K36Me3 Recognition by the Pwwp Domain of Brpf1. Nat.Struct.Mol.Biol., 17, 2010
6SEF	Class2C : CENP-A nucleosome in complex with CENP-C central region Descriptor: Centromere protein C, DNA (145-MER), Histone H2A type 2-A, ... Authors: Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. Deposit date: 2019-07-29 Release date: 2019-08-14 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
8YN8	Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo Descriptor: 5-(3-phenylmethoxypropyl)-1H-imidazole, Antibody fragment scFv16, CHOLESTEROL, ... Authors: Zhang, X, Liu, G, Li, X, Gong, W. Deposit date: 2024-03-10 Release date: 2024-10-16 Last modified: 2024-11-27 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structural basis of ligand recognition and activation of the histamine receptor family. Nat Commun, 15, 2024
8YN7	Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo Descriptor: 4-(1H-imidazol-4-ylmethyl)pyridine, Antibody fragment scFv16, CHOLESTEROL, ... Authors: Zhang, X, Liu, G, Li, X, Gong, W. Deposit date: 2024-03-10 Release date: 2024-10-16 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structural basis of ligand recognition and activation of the histamine receptor family. Nat Commun, 15, 2024
8YN6	Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi Descriptor: 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, Antibody fragment scFv16, CHOLESTEROL, ... Authors: Zhang, X, Liu, G, Li, X, Gong, W. Deposit date: 2024-03-10 Release date: 2024-10-09 Last modified: 2024-11-27 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structural basis of ligand recognition and activation of the histamine receptor family. Nat Commun, 15, 2024
8YN5	Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi Descriptor: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Zhang, X, Liu, G, Li, X, Gong, W. Deposit date: 2024-03-10 Release date: 2024-10-09 Last modified: 2024-11-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural basis of ligand recognition and activation of the histamine receptor family. Nat Commun, 15, 2024
4IUV	crystal structure of SHH1 SAWADEE domain in complex with H3K4me1K9me1 peptide Descriptor: CYMAL-4, Histone H3.2, H3(1-15)K9me3, ... Authors: Du, J, Patel, D.J. Deposit date: 2013-01-21 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature, 498, 2013
6UPH	Structure of a Yeast Centromeric Nucleosome at 2.7 Angstrom resolution Descriptor: DNA (119-MER), Histone H2A, Histone H2B.1, ... Authors: Migl, D, Kschonsak, M, Arthur, C.P, Khin, Y, Harrison, S.C, Ciferri, C, Dimitrova, Y.N. Deposit date: 2019-10-17 Release date: 2019-11-06 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 angstrom Resolution. Structure, 28, 2020
3LQJ	Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide Descriptor: Histone H3, MLL1 PHD3-Bromo, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2010-02-09 Release date: 2010-07-07 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
6HGT	Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation Descriptor: Histone H3.3, Lysine-specific demethylase 4A, N-OXALYLGLYCINE, ... Authors: Maw, J, Le Bihan, Y.V, van Montfort, R.L.M. Deposit date: 2018-08-23 Release date: 2019-09-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily To be published
3KV4	Structure of PHF8 in complex with histone H3 Descriptor: 1,2-ETHANEDIOL, FE (II) ION, Histone H3-like, ... Authors: Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X. Deposit date: 2009-11-29 Release date: 2009-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat.Struct.Mol.Biol., 17, 2010
3LQI	Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me2 peptide Descriptor: Histone H3, MLL1 PHD3-Bromo, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2010-02-09 Release date: 2010-07-07 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
3KWQ	Structural characterization of H3K56Q nucleosomes and nucleosomal arrays Descriptor: DNA (146-MER), Histone H2A, Histone H2B 1.1, ... Authors: Lilyestrom, W.G, Clark, N. Deposit date: 2009-12-01 Release date: 2010-05-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural characterization of H3K56Q nucleosomes and nucleosomal arrays. Biochim.Biophys.Acta, 1799
5UMN	Crystal structure of C05 VPGSGW mutant bound to H3 influenza hemagglutinin, HA1 subunit Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 VPGSGW mutant, heavy chain, ... Authors: Wu, N.C, Wilson, I.A. Deposit date: 2017-01-27 Release date: 2017-05-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.97 Å) Cite: In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity. Nat Commun, 8, 2017
4QEN	crystal structure of KRYPTONITE in complex with mCHH DNA and SAH Descriptor: DNA (5'-D(*AP*CP*TP*GP*AP*TP*GP*AP*GP*TP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*GP*GP*TP*AP*CP*TP*(5CM)P*AP*TP*CP*AP*GP*TP*AP*T)-3'), Histone-lysine N-methyltransferase, ... Authors: Du, J, Li, S, Patel, D.J. Deposit date: 2014-05-17 Release date: 2014-07-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.002 Å) Cite: Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell, 55, 2014
8T0P	Structure of Cse4 bound to Ame1 and Okp1 Descriptor: Histone H3-like centromeric protein CSE4, Inner kinetochore subunit AME1, Inner kinetochore subunit OKP1, ... Authors: Deng, S, Harrison, S.C. Deposit date: 2023-06-01 Release date: 2023-09-27 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex. Embo Rep., 24, 2023
7QPH	Crystal structure of mouse CARM1 in complex with histone H3_22-31 K27 acetylated Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-ETHANEDIOL, Histone H3 22-31 K27 acetylated, ... Authors: Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J. Deposit date: 2022-01-04 Release date: 2023-01-18 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: CARM1 Transition State Mimics To Be Published
4FT2	crystal structure of Zea mays ZMET2 in complex H3(1-15)K9me2 peptide and SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, H3 peptide, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
4FWF	Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... Authors: Zhang, Q, Chen, Z. Deposit date: 2012-07-01 Release date: 2013-01-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013

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