7NCA
 
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6V6M
 | | Crystal structure of an inactive state of GMPPNP-bound RhoA | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Lin, Y, Zheng, Y. | | Deposit date: | 2019-12-05 | | Release date: | 2020-12-09 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Structure of an inactive conformation of GTP-bound RhoA GTPase.
Structure, 29, 2021
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6V6U
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6V6V
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2G5M
 | | Spinophilin PDZ domain | | Descriptor: | Neurabin-2 | | Authors: | Kelker, M.S, Peti, W. | | Deposit date: | 2006-02-23 | | Release date: | 2007-01-09 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural basis for spinophilin-neurabin receptor interaction.
Biochemistry, 46, 2007
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1RHG
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3WA0
 | | Crystal structure of merlin complexed with DCAF1/VprBP | | Descriptor: | Merlin, Protein VPRBP | | Authors: | Mori, T, Gotoh, S, Shirakawa, M, Hakoshima, T. | | Deposit date: | 2013-04-20 | | Release date: | 2014-05-28 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Genes Cells, 19, 2014
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4XZF
 | | Crystal structure of HIRAN domain of human HLTF in complex with DNA | | Descriptor: | (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor | | Authors: | Hishiki, A, Hashimoto, H. | | Deposit date: | 2015-02-04 | | Release date: | 2015-04-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
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5M9Q
 | | Human angiogenin PD variant R95Q | | Descriptor: | Angiogenin, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | | Authors: | Bradshaw, W.J, Rehman, S, Pham, T.T.K, Thiyagarajan, N, Lee, R.L, Subramanian, V, Acharya, K.R. | | Deposit date: | 2016-11-02 | | Release date: | 2017-02-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
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7PG5
 | | Crystal Structure of PI3Kalpha | | Descriptor: | GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | | Authors: | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | | Deposit date: | 2021-08-13 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.20029068 Å) | | Cite: | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
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5M9T
 | | Human angiogenin ALS variant H114R | | Descriptor: | Angiogenin, BORATE ION, GLYCEROL | | Authors: | Bradshaw, W.J, Rehman, S, Pham, T.T.K, Thiyagarajan, N, Lee, R.L, Subramanian, V, Acharya, K.R. | | Deposit date: | 2016-11-02 | | Release date: | 2017-02-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
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7PG6
 | | Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 | | Descriptor: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | | Authors: | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | | Deposit date: | 2021-08-13 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.49943733 Å) | | Cite: | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
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1HQ0
 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF E.COLI CYTOTOXIC NECROTIZING FACTOR TYPE 1 | | Descriptor: | CYTOTOXIC NECROTIZING FACTOR 1, PHOSPHATE ION | | Authors: | Buetow, L, Flatau, G, Chiu, K, Boquet, P, Ghosh, P. | | Deposit date: | 2000-12-13 | | Release date: | 2001-07-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1.
Nat.Struct.Biol., 8, 2001
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1HZG
 | | CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1 | | Descriptor: | CYTOTOXIC NECROTIZING FACTOR 1, PHOSPHATE ION | | Authors: | Buetow, L, Flatau, G, Chiu, K, Boquet, P, Ghosh, P. | | Deposit date: | 2001-01-24 | | Release date: | 2001-07-04 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1.
Nat.Struct.Biol., 8, 2001
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7QJ3
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7QJ2
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7QJ1
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7QJE
 | | Structure of recombinant human gamma-Tubulin Ring Complex 4-spoked assembly intermediate (spokes 9-12) | | Descriptor: | Gamma-tubulin complex component 4, Gamma-tubulin complex component 5, Gamma-tubulin complex component 6, ... | | Authors: | Tonon, G, Zupa, E, Pfeffer, S. | | Deposit date: | 2021-12-16 | | Release date: | 2022-01-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Modular assembly of the principal microtubule nucleator gamma-TuRC.
Nat Commun, 13, 2022
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7QJ4
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7QJ0
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5NZC
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7QSC
 | | GTPase IN COMPLEX WITH GDP.MGF3- | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 1, ... | | Authors: | Baumann, P, Jin, Y. | | Deposit date: | 2022-01-13 | | Release date: | 2023-01-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | GTPase IN COMPLEX WITH GDP.MGF3-
To Be Published
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7QTM
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5M70
 | | Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 1, ... | | Authors: | Pellegrini, E, Bowler, M.W. | | Deposit date: | 2016-10-26 | | Release date: | 2017-05-17 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches.
Angew. Chem. Int. Ed. Engl., 56, 2017
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5M9M
 | | Human angiogenin PD variant Q77P | | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Angiogenin, ... | | Authors: | Bradshaw, W.J, Rehman, S, Pham, T.T.K, Thiyagarajan, N, Lee, R.L, Subramanian, V, Acharya, K.R. | | Deposit date: | 2016-11-01 | | Release date: | 2017-02-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
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