1ZO1
 
 | | IF2, IF1, and tRNA fitted to cryo-EM data OF E. COLI 70S initiation complex | | Descriptor: | P/I-site tRNA, translation Initiation Factor 1, translation initiation factor 2 | | Authors: | Allen, G.S, Zavialov, A, Gursky, R, Ehrenberg, M, Frank, J. | | Deposit date: | 2005-05-12 | | Release date: | 2005-06-14 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (13.8 Å) | | Cite: | The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli.
Cell(Cambridge,Mass.), 121, 2005
|
|
7TUV
 | |
7OQP
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ113 | | Descriptor: | ACETATE ION, N-[[(3R)-1-[6-(1-benzothiophen-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, N6-adenosine-methyltransferase catalytic subunit, ... | | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | | Deposit date: | 2021-06-03 | | Release date: | 2021-10-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
|
|
7OQO
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ111 | | Descriptor: | 2-oxidanyl-N-[[(3R)-3-oxidanyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methyl]-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | | Deposit date: | 2021-06-03 | | Release date: | 2021-10-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
|
|
7OQL
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ094 | | Descriptor: | (3~{R})-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-3-[[[6-[[(3~{S})-3-propan-2-yl-2-azoniaspiro[3.3]heptan-2-yl]methyl]naphthalen-1-yl]amino]methyl]piperidin-3-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | | Deposit date: | 2021-06-03 | | Release date: | 2021-10-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
|
|
7MQB
 | | Bartonella henselae NrnC bound to pGG. D4 Symmetry | | Descriptor: | NanoRNase C, RNA (5'-R(P*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQD
 | | Bartonella henselae NrnC complexed with pAGG. D4 symmetry. | | Descriptor: | NanoRNase C, RNA (5'-R(P*AP*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQG
 | | Bartonella henselae NrnC complexed with pAAAGG. C1 reconstruction. | | Descriptor: | NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQC
 | | Bartonella henselae NrnC bound to pGG. C1 reconstruction. | | Descriptor: | NanoRNase C, RNA (5'-R(P*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQI
 | | Bartonella henselae NrnC complexed with pAAAGG in the presence of Ca2+. C1 reconstruction. | | Descriptor: | NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQH
 | | Bartonella henselae NrnC complexed with pAAAGG in the presence of Ca2+. D4 Symmetry. | | Descriptor: | NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQF
 | | Bartonella henselae NrnC complexed with pAAAGG. D4 symmetry. | | Descriptor: | NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
7MQE
 | | Bartonella henselae NrnC complexed with pAGG. C1 reconstruction. | | Descriptor: | NanoRNase C, RNA (5'-R(P*AP*GP*G)-3') | | Authors: | Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H. | | Deposit date: | 2021-05-05 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
|
|
5HMX
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 | | Descriptor: | 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | | Authors: | Noble, C.G. | | Deposit date: | 2016-01-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
|
|
5HMZ
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 | | Descriptor: | 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, RNA-directed RNA polymerase NS5, ZINC ION | | Authors: | Noble, C.G. | | Deposit date: | 2016-01-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
|
|
5HMY
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 | | Descriptor: | 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | | Authors: | Noble, C.G. | | Deposit date: | 2016-01-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
|
|
5HMW
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 | | Descriptor: | 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | | Authors: | Noble, C.G. | | Deposit date: | 2016-01-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
|
|
5EX7
 | | Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA | | Descriptor: | Brain tumor protein, RNA (5'-R(P*UP*UP*UP*GP*UP*UP*GP*U)-3') | | Authors: | Wang, Y, Yu, Z, Wang, M, Liu, C.P, Yang, N, Xu, R.M. | | Deposit date: | 2015-11-23 | | Release date: | 2015-12-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA
To Be Published
|
|
2C35
 | | Subunits Rpb4 and Rpb7 of human RNA polymerase II | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 19 KDA POLYPEPTIDE | | Authors: | Meka, H, Werner, F, Cordell, S.C, Onesti, S, Brick, P. | | Deposit date: | 2005-10-04 | | Release date: | 2005-11-18 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure and RNA Binding of the Rpb4/Rpb7 Subunits of Human RNA Polymerase II.
Nucleic Acids Res., 33, 2005
|
|
8BF8
 | | ISDra2 TnpB in complex with reRNA | | Descriptor: | Deinococcus radiodurans R1 chromosome 1, RNA-guided DNA endonuclease TnpB | | Authors: | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Siksnys, V, Montoya, G, Druteika, G, Silanskas, A, Venclovas, C, Karvelis, T, Kazlauskas, D. | | Deposit date: | 2022-10-24 | | Release date: | 2023-04-12 | | Last modified: | 2023-04-26 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | TnpB structure reveals minimal functional core of Cas12 nuclease family.
Nature, 616, 2023
|
|
8GWB
 | | SARS-CoV-2 E-RTC complex with RNA-nsp9 | | Descriptor: | Helicase, MANGANESE (II) ION, Non-structural protein 7, ... | | Authors: | Yan, L.M, Rao, Z.H, Lou, Z.Y. | | Deposit date: | 2022-09-16 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
|
|
8GWE
 | | SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP | | Descriptor: | Helicase nsp13, MAGNESIUM ION, Non-structural protein 8, ... | | Authors: | Yan, L.M, Rao, Z.H, Lou, Z.Y. | | Deposit date: | 2022-09-16 | | Release date: | 2023-01-11 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
|
|
8CYF
 | | WhiB3 bound to SigmaAr4-RNAP Beta flap tip chimera and DNA | | Descriptor: | CACODYLATE ION, DNA (5'-D(*CP*AP*CP*CP*AP*CP*AP*AP*CP*CP*GP*AP*TP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*AP*AP*AP*TP*CP*GP*GP*TP*TP*GP*TP*GP*GP*T)-3'), ... | | Authors: | Wan, T, Zhang, L.M. | | Deposit date: | 2022-05-23 | | Release date: | 2023-05-17 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis.
J.Biol.Chem., 299, 2023
|
|
404D
 | |
8WT7
 | | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange locked state | | Descriptor: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishimasu, H. | | Deposit date: | 2023-10-18 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural mechanism of bridge RNA-guided recombination
Nature, 630, 2024
|
|
