PDB: 72308 resultsInfo pagesStatus searchChemie searchBIRD

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8G7T	Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-end) Descriptor: Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ZINC ION, ... Authors: Wang, W, Pyle, A.M. Deposit date: 2023-02-17 Release date: 2023-11-15 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization. Nat Commun, 14, 2023
8G7V	Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-inter) Descriptor: Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ZINC ION, ... Authors: Wang, W, Pyle, A.M. Deposit date: 2023-02-17 Release date: 2023-11-15 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization. Nat Commun, 14, 2023
4WTD	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ... Authors: Edwards, T.E, Fox III, D, Appleby, T.C. Deposit date: 2014-10-29 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTF	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU Descriptor: 2'-C-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ... Authors: Edwards, T.E, Appleby, T.C, Mcgrath, M.E. Deposit date: 2014-10-30 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4PZ7	PCE1 guanylyltransferase Descriptor: GLYCEROL, SULFATE ION, mRNA-capping enzyme subunit alpha Authors: Doamekpor, S.K, Lima, C.D. Deposit date: 2014-03-28 Release date: 2014-06-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.109 Å) Cite: How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev., 28, 2014
4WTA	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU Descriptor: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER TEMPLATE CAAAAUUU, ... Authors: Edwards, T.E, Appleby, T.C. Deposit date: 2014-10-29 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTC	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU Descriptor: CHLORIDE ION, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Edwards, T.E, Appleby, T.C. Deposit date: 2014-10-29 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTE	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-ACAAAUUU Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Edwards, T.E, Appleby, T.C. Deposit date: 2014-10-29 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTG	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH SOFOSBUVIR DIPHOSPHATE GS-607596, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU Descriptor: 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ... Authors: Edwards, T.E, Appleby, T.C. Deposit date: 2014-10-30 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
6UCA	Crystal structure of human ZCCHC4 in complex with SAH Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, rRNA N6-adenosine-methyltransferase ZCCHC4 Authors: Lu, J.W, Ren, W.D, Huang, M.J, Gao, L, Li, D.X, Wang, G.G, Song, J. Deposit date: 2019-09-15 Release date: 2019-10-16 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.103 Å) Cite: Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. Nat Commun, 10, 2019
4PZ8	PCE1 guanylyltransferase bound to SPT5 CTD Descriptor: SULFATE ION, Transcription elongation factor spt5, mRNA-capping enzyme subunit alpha Authors: Doamekpor, S.K, Lima, C.D. Deposit date: 2014-03-28 Release date: 2014-06-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev., 28, 2014
6LSF	Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form) Descriptor: Genome polyprotein, RNA (35-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), ... Authors: Wang, M, Shu, B, Jing, X, Gong, P. Deposit date: 2020-01-17 Release date: 2020-04-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.152 Å) Cite: Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun, 11, 2020
4LAB	Crystal structure of the catalytic domain of RluB Descriptor: CHLORIDE ION, PLATINUM (II) ION, Ribosomal large subunit pseudouridine synthase B Authors: Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. Deposit date: 2013-06-19 Release date: 2013-11-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5043 Å) Cite: The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res., 42, 2014
7PP4	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-09-13 Release date: 2022-09-21 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Biorxiv, 2022
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-03 Release date: 2022-11-16 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
6JCX	Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt RNA Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.903 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
8PNQ	Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-30 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PNP	Influenza A/H7N9 polymerase in pre-initiation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 51-mer vRNA loop (v51_mut_S), Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-30 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (2.49 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
7KRP	Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement) Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHAPSO, MAGNESIUM ION, ... Authors: Chen, J, Malone, B, Campbell, E.A, Darst, S.A. Deposit date: 2020-11-20 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
8X6F	Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex Descriptor: DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yuan, L, Xu, L, Liu, Q, Feng, Y. Deposit date: 2023-11-21 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
8GZP	Cryo-EM structure of the NS5-SLA complex Descriptor: GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... Authors: Osawa, T, Ehara, H, Sekine, S. Deposit date: 2022-09-27 Release date: 2023-08-02 Last modified: 2023-08-23 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
5WT3	Pyrococcus abyssi methyltransferase PaTrm5a bound by MTA and cognate tRNA Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, RNA (73-MER), tRNA (guanine(37)-N1)-methyltransferase Trm5a Authors: Xie, W, Wang, C, Jia, Q. Deposit date: 2016-12-09 Release date: 2017-12-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.204 Å) Cite: Structural insight into the methyltransfer mechanism of the bifunctional Trm5. Sci Adv, 3, 2017
3T0O	Crystal Structure Analysis of Human RNase T2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ribonuclease T2 Authors: Thorn, A, Kraetzner, R, Steinfeld, R, Sheldrick, G. Deposit date: 2011-07-20 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Structure and activity of the only human RNase T2. Nucleic Acids Res., 40, 2012
1A60	NMR STRUCTURE OF A CLASSICAL PSEUDOKNOT: INTERPLAY OF SINGLE-AND DOUBLE-STRANDED RNA, 24 STRUCTURES Descriptor: TYMV PSEUDOKNOT Authors: Kolk, M.H, Van Der Graaf, M, Wijmenga, S.S, Pleij, C.W.A, Heus, H.A, Hilbers, C.W. Deposit date: 1998-03-04 Release date: 1998-05-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: NMR structure of a classical pseudoknot: interplay of single- and double-stranded RNA. Science, 280, 1998
5H0R	RNA dependent RNA polymerase ,vp4,dsRNA Descriptor: RNA (42-MER), RNA-dependent RNA polymerase, VP4 protein Authors: Li, X, Zhou, N, Chen, W, Zhu, B, Wang, X, Xu, B, Wang, J, Liu, H, Cheng, L. Deposit date: 2016-10-06 Release date: 2017-01-25 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV J. Mol. Biol., 429, 2017

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