6RT1
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![BU of 6rt1 by Molmil](/molmil-images/mine/6rt1) | Native tetragonal lysozyme - home source data | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... | Authors: | Pereira, P.J.B. | Deposit date: | 2019-05-22 | Release date: | 2019-05-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.336 Å) | Cite: | Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions. Phys Chem Chem Phys, 22, 2020
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6BVK
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![BU of 6bvk by Molmil](/molmil-images/mine/6bvk) | Ras:SOS:Ras in complex with a small molecule activator | Descriptor: | FORMIC ACID, GLYCEROL, GTPase HRas, ... | Authors: | Phan, J, Abbott, J, Fesik, S.W. | Deposit date: | 2017-12-13 | Release date: | 2018-10-24 | Last modified: | 2019-05-01 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. J. Med. Chem., 61, 2018
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6RGM
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![BU of 6rgm by Molmil](/molmil-images/mine/6rgm) | urate oxidase under 130 bar of krypton | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | Authors: | Prange, T, Colloc'h, N, Carpentier, P. | Deposit date: | 2019-04-17 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization Acta Cryst. D, 78, 2022
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5H3Q
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![BU of 5h3q by Molmil](/molmil-images/mine/5h3q) | Crystal Structure of TrkA kinase with ligand | Descriptor: | 1-[(3S,4R)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, High affinity nerve growth factor receptor, ... | Authors: | Noritaka, F. | Deposit date: | 2016-10-26 | Release date: | 2017-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity Bioorg. Med. Chem. Lett., 27, 2017
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6ARC
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![BU of 6arc by Molmil](/molmil-images/mine/6arc) | |
5GJP
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6AW5
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![BU of 6aw5 by Molmil](/molmil-images/mine/6aw5) | 1.90A resolution structure of catechol O-methyltransferase (COMT) L136M (hexagonal form) from Nannospalax galili | Descriptor: | CHLORIDE ION, Catechol O-methyltransferase, GLYCEROL, ... | Authors: | Lovell, S, Mehzabeen, N, Battaile, K.P, Deng, Y, Hanzlik, R.P, Shams, I, Moskovitz, J. | Deposit date: | 2017-09-05 | Release date: | 2018-09-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution To be published
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6B91
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![BU of 6b91 by Molmil](/molmil-images/mine/6b91) | Crystal structure of the N-terminal domain of human METTL16 | Descriptor: | 1,2-ETHANEDIOL, SODIUM ION, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase | Authors: | Ruszkowska, A, Ruszkowski, M, Dauter, Z, Brown, J.A. | Deposit date: | 2017-10-09 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural insights into the RNA methyltransferase domain of METTL16. Sci Rep, 8, 2018
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6TLR
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![BU of 6tlr by Molmil](/molmil-images/mine/6tlr) | HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,7-DIBROMOBENZOTRIAZOLE | Descriptor: | 4,7-bis(bromanyl)-1~{H}-benzotriazole, CHLORIDE ION, Casein kinase II subunit alpha, ... | Authors: | Czapinska, H, Piasecka, A, Winiewska-Szajewska, M, Bochtler, M, Poznanski, J. | Deposit date: | 2019-12-03 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2. J.Phys.Chem.B, 125, 2021
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6TFH
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5GZC
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![BU of 5gzc by Molmil](/molmil-images/mine/5gzc) | Crystal structure of Galectin-8 N-CRD with part of linker | Descriptor: | GLYCEROL, Galectin-8, SODIUM ION | Authors: | Su, J.Y, Si, Y.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci, 17, 2016
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6TLS
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![BU of 6tls by Molmil](/molmil-images/mine/6tls) | HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,6-DIBROMOBENZOTRIAZOLE | Descriptor: | 5,7-bis(bromanyl)-1~{H}-benzotriazole, CHLORIDE ION, Casein kinase II subunit alpha, ... | Authors: | Czapinska, H, Piasecka, A, Winiewska-Szajewska, M, Bochtler, M, Poznanski, J. | Deposit date: | 2019-12-03 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2. J.Phys.Chem.B, 125, 2021
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6CBV
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![BU of 6cbv by Molmil](/molmil-images/mine/6cbv) | Crystal structure of BRIL bound to an affinity matured synthetic antibody. | Descriptor: | BRIL, FORMIC ACID, GLYCEROL, ... | Authors: | Mukherjee, S, Skrobek, B, Kossiakoff, A.A. | Deposit date: | 2018-02-05 | Release date: | 2019-02-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.872 Å) | Cite: | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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6TK2
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![BU of 6tk2 by Molmil](/molmil-images/mine/6tk2) | Femtosecond to millisecond structural changes in a light-driven sodium pump: 1ms structure of KR2 with extrapolated, light and dark datasets | Descriptor: | EICOSANE, RETINAL, SODIUM ION, ... | Authors: | Skopintsev, P, Ehrenberg, D, Weinert, T, James, D, Kar, R, Johnson, P, Ozerov, D, Furrer, A, Martiel, I, Dworkowski, F, Nass, K, Knopp, G, Cirelli, C, Gashi, D, Mous, S, Wranik, M, Gruhl, T, Kekilli, D, Bruenle, S, Deupi, X, Schertler, G.F.X, Benoit, R, Panneels, V, Nogly, P, Schapiro, I, Milne, C, Heberle, J, Standfuss, J. | Deposit date: | 2019-11-28 | Release date: | 2020-05-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Femtosecond-to-millisecond structural changes in a light-driven sodium pump. Nature, 583, 2020
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6TLL
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![BU of 6tll by Molmil](/molmil-images/mine/6tll) | HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (tBBT) | Descriptor: | 4,5,6,7-TETRABROMOBENZOTRIAZOLE, CHLORIDE ION, Casein kinase II subunit alpha, ... | Authors: | Czapinska, H, Piasecka, A, Winiewska-Szajewska, M, Bochtler, M, Poznanski, J. | Deposit date: | 2019-12-03 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2. J.Phys.Chem.B, 125, 2021
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6BNI
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6C2Z
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![BU of 6c2z by Molmil](/molmil-images/mine/6c2z) | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PLP-Aminoacrylate Intermediate | Descriptor: | 1,2-ETHANEDIOL, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CALCIUM ION, ... | Authors: | Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D. | Deposit date: | 2018-01-09 | Release date: | 2018-04-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 57, 2018
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6BGQ
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![BU of 6bgq by Molmil](/molmil-images/mine/6bgq) | Caspase-3 Mutant - S150D | Descriptor: | AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, CHLORIDE ION, ... | Authors: | Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. | Deposit date: | 2017-10-29 | Release date: | 2018-02-21 | Last modified: | 2018-04-25 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
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5EM0
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![BU of 5em0 by Molmil](/molmil-images/mine/5em0) | Crystal structure of mugwort allergen Art v 4 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Pollen allergen Art v 4.01, SODIUM ION | Authors: | Offermann, L.R, Perdue, M.L, Chruszcz, M. | Deposit date: | 2015-11-05 | Release date: | 2016-06-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2. J.Biol.Chem., 291, 2016
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5EN3
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![BU of 5en3 by Molmil](/molmil-images/mine/5en3) | Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution | Descriptor: | 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, GLYCEROL, SODIUM ION, ... | Authors: | Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E. | Deposit date: | 2015-11-09 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. Plos One, 11, 2016
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5EVJ
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![BU of 5evj by Molmil](/molmil-images/mine/5evj) | X-ray crystal structure of CrArsM, an arsenic (III) S-adenosylmethionine methyltransferase from Chlamydomonas reinhardtii | Descriptor: | Arsenite methyltransferase, SODIUM ION | Authors: | Packianathan, C, Kandavelu, P, Sankaran, B, Rosen, B.P. | Deposit date: | 2015-11-19 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of CrArsM, an arsenic (III) S-adenosylmethionine methyltransferase from Chlamydomonas reinhardtii To Be Published
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5EY7
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6BRE
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![BU of 6bre by Molmil](/molmil-images/mine/6bre) | Hen Egg-White Lysozyme cocrystallized with Cadmium sulphate using CuKalpha source. | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Sakon, J, Caviness, P, Jack, T, Pickens, J.B, Reed, P, Ruth, C. | Deposit date: | 2017-11-30 | Release date: | 2018-01-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Hen Egg-White Lysozyme (HEWL) cocrystallized with Cadmium sulphate. To Be Published
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5F16
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![BU of 5f16 by Molmil](/molmil-images/mine/5f16) | CTA-modified hen egg-white lysozyme | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | Authors: | McGlone, C, Nix, J.C, Page, R.C. | Deposit date: | 2015-11-30 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates. Biomacromolecules, 17, 2016
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6CUP
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![BU of 6cup by Molmil](/molmil-images/mine/6cup) | Ras:SOS:Ras in complex with a small molecule activator | Descriptor: | FORMIC ACID, GLYCEROL, GTPase HRas, ... | Authors: | Phan, J, Abbott, J, Fesik, S.W. | Deposit date: | 2018-03-26 | Release date: | 2019-02-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.833 Å) | Cite: | Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS. ACS Med Chem Lett, 9, 2018
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