6TLL

HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (tBBT)

Summary for 6TLL

Entry DOI	10.2210/pdb6tll/pdb
Descriptor	Casein kinase II subunit alpha, 4,5,6,7-TETRABROMOBENZOTRIAZOLE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	ck2, casein kinase 2, inhibitor, bromo-benzotriazole, halogen bond, transferase-transferase inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	47455.25
Authors	Czapinska, H.,Piasecka, A.,Winiewska-Szajewska, M.,Bochtler, M.,Poznanski, J. (deposition date: 2019-12-03, release date: 2020-12-16, Last modification date: 2024-01-24)
Primary citation	Czapinska, H.,Winiewska-Szajewska, M.,Szymaniec-Rutkowska, A.,Piasecka, A.,Bochtler, M.,Poznanski, J. Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2. J.Phys.Chem.B, 125:2491-2503, 2021 Cited by PubMed: 33689348 DOI: 10.1021/acs.jpcb.0c10264 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation