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6TLL

HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (tBBT)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000166molecular_functionnucleotide binding
A0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
A0000724biological_processdouble-strand break repair via homologous recombination
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005956cellular_componentprotein kinase CK2 complex
A0006302biological_processdouble-strand break repair
A0006357biological_processregulation of transcription by RNA polymerase II
A0006457biological_processprotein folding
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0017148biological_processnegative regulation of translation
A0030163biological_processprotein catabolic process
A0030177biological_processpositive regulation of Wnt signaling pathway
A0030307biological_processpositive regulation of cell growth
A0031519cellular_componentPcG protein complex
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035973biological_processaggrephagy
A0042176biological_processregulation of protein catabolic process
A0042802molecular_functionidentical protein binding
A0045732biological_processpositive regulation of protein catabolic process
A0045947biological_processnegative regulation of translational initiation
A0048511biological_processrhythmic process
A0050821biological_processprotein stabilization
A0051726biological_processregulation of cell cycle
A0051879molecular_functionHsp90 protein binding
A0070822cellular_componentSin3-type complex
A0071211biological_processprotein targeting to vacuole involved in autophagy
A0075342biological_processsymbiont-mediated disruption of host cell PML body
A0097194biological_processexecution phase of apoptosis
A0097680biological_processdouble-strand break repair via classical nonhomologous end joining
A0106310molecular_functionprotein serine kinase activity
A0140694biological_processmembraneless organelle assembly
A1901797biological_processnegative regulation of signal transduction by p53 class mediator
A1905337biological_processpositive regulation of aggrephagy
A1905818biological_processregulation of chromosome separation
A1990166biological_processprotein localization to site of double-strand break
A2000042biological_processnegative regulation of double-strand break repair via homologous recombination
A2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue TBS A 401
ChainResidue
AVAL53
AHIS160
AMET163
AILE174
AASP175
AHOH702
AHOH786
AHOH851
AVAL66
ALYS68
AILE95
APHE113
AGLU114
AVAL116
AASN117
AASN118

site_idAC2
Number of Residues15
Detailsbinding site for residue TBS A 402
ChainResidue
AARG21
AGLN36
ATYR39
ALEU41
AILE69
AVAL101
AASP103
ASER106
ATHR108
AALA110
AHOH518
AHOH571
AHOH611
AHOH818
AHOH846

site_idAC3
Number of Residues8
Detailsbinding site for residue PEG A 403
ChainResidue
AARG89
AGLY90
ATYR146
AHOH508
AHOH614
AHOH640
AHOH715
AHOH934

site_idAC4
Number of Residues5
Detailsbinding site for residue PEG A 404
ChainResidue
AARG10
AGLU282
AGLN310
ASER311
AHOH687

site_idAC5
Number of Residues6
Detailsbinding site for residue NA A 405
ChainResidue
AGLN290
AVAL293
AHOH538
AHOH721
AHOH727
AHOH862

site_idAC6
Number of Residues2
Detailsbinding site for residue CL A 406
ChainResidue
APRO159
AHIS160

site_idAC7
Number of Residues4
Detailsbinding site for residue CL A 407
ChainResidue
AARG280
AHOH719
AHOH773
AHOH788

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK
ChainResidueDetails
ALEU45-LYS68

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
AILE152-ILE164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP156

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU45
ALYS68

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773
ChainResidueDetails
ATHR344
ATHR360

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773
ChainResidueDetails
ASER362

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773, ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER370

237735

PDB entries from 2025-06-18

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