6CUP

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6CUP

• Entry DOI: 10.2210/pdb6cup/pdb
• Descriptor: GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
• Functional Keywords: ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 95764.82

Authors

Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2018-03-26, release date: 2019-02-06, Last modification date: 2023-11-15)

• Primary citation: Abbott, J.R.,Patel, P.A.,Howes, J.E.,Akan, D.T.,Kennedy, J.P.,Burns, M.C.,Browning, C.F.,Sun, Q.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.; Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.; ACS Med Chem Lett, 9:941-946, 2018; PubMed: 30258545; DOI: 10.1021/acsmedchemlett.8b00296

Experimental method

X-RAY DIFFRACTION (1.833 Å)