6OWJ
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![BU of 6owj by Molmil](/molmil-images/mine/6owj) | Zn-mediated polymerization of human SFPQ | Descriptor: | Splicing factor, proline- and glutamine-rich, ZINC ION | Authors: | Lee, M. | Deposit date: | 2019-05-10 | Release date: | 2020-02-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ. Nucleic Acids Res., 48, 2020
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1AQF
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![BU of 1aqf by Molmil](/molmil-images/mine/1aqf) | PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE | Descriptor: | L-PHOSPHOLACTATE, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Larsen, T.M, Benning, M.M, Wesenberg, G.E, Rayment, I, Reed, G.H. | Deposit date: | 1997-07-29 | Release date: | 1998-09-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ligand-induced domain movement in pyruvate kinase: structure of the enzyme from rabbit muscle with Mg2+, K+, and L-phospholactate at 2.7 A resolution. Arch.Biochem.Biophys., 345, 1997
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5F6D
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![BU of 5f6d by Molmil](/molmil-images/mine/5f6d) | Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 | Descriptor: | 6~{H}-benzo[c][1,2]benzothiazine 5,5-dioxide, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-05 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.553 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6W
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![BU of 5f6w by Molmil](/molmil-images/mine/5f6w) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) | Descriptor: | 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6V
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![BU of 5f6v by Molmil](/molmil-images/mine/5f6v) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol from fragment cocktail screen) | Descriptor: | 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.492 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6X
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![BU of 5f6x by Molmil](/molmil-images/mine/5f6x) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from cocktail screen) | Descriptor: | 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6E
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![BU of 5f6e by Molmil](/molmil-images/mine/5f6e) | Crystal Structure of human Ubc9 (K48A/K49A/E54A) | Descriptor: | 1,2-ETHANEDIOL, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-05 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6U
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![BU of 5f6u by Molmil](/molmil-images/mine/5f6u) | Crystal Structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 8 (JSS190B146) | Descriptor: | SUMO-conjugating enzyme UBC9, ethyl 3-[4-(2-hydroxyphenyl)-3-oxidanyl-phenyl]propanoate | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.552 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6Y
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![BU of 5f6y by Molmil](/molmil-images/mine/5f6y) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole) | Descriptor: | 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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3NQU
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![BU of 3nqu by Molmil](/molmil-images/mine/3nqu) | |
6TNY
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![BU of 6tny by Molmil](/molmil-images/mine/6tny) | Processive human polymerase delta holoenzyme | Descriptor: | DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... | Authors: | Lancey, C, Hamdan, S.M, De Biasio, A. | Deposit date: | 2019-12-10 | Release date: | 2019-12-18 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
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6UYO
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![BU of 6uyo by Molmil](/molmil-images/mine/6uyo) | Crystal structure of K37-acetylated SUMO1 in complex with PML-SIM | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.639 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6UYX
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![BU of 6uyx by Molmil](/molmil-images/mine/6uyx) | Crystal structure of K37-acetylated SUMO1 in complex with phosphorylated DAXX | Descriptor: | Small ubiquitin-related modifier 1, phosphorylated DAXX | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6V5C
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![BU of 6v5c by Molmil](/molmil-images/mine/6v5c) | Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state | Descriptor: | Microprocessor complex subunit DGCR8, Pri-miR-16-2 (66-MER), Ribonuclease 3 | Authors: | Partin, A, Zhang, K, Jeong, B, Herrell, E, Li, S, Chiu, W, Nam, Y. | Deposit date: | 2019-12-04 | Release date: | 2020-04-08 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol.Cell, 78, 2020
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4RPP
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![BU of 4rpp by Molmil](/molmil-images/mine/4rpp) | crystal structure of PKM2-K422R mutant bound with FBP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, Pyruvate kinase PKM | Authors: | Wang, P, Sun, C, Zhu, T, Xu, Y. | Deposit date: | 2014-10-31 | Release date: | 2015-02-25 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.585 Å) | Cite: | Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell, 6, 2015
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6UPL
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![BU of 6upl by Molmil](/molmil-images/mine/6upl) | Structure of FACT_subnucleosome complex 2 | Descriptor: | DNA (79-mer), FACT complex subunit SPT16, FACT complex subunit SSRP1, ... | Authors: | Zhou, K, Tan, Y.Z, Wei, H, Liu, Y, Carragher, B, Potter, C, Luger, K. | Deposit date: | 2019-10-17 | Release date: | 2019-12-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | FACT caught in the act of manipulating the nucleosome. Nature, 577, 2020
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6UPK
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![BU of 6upk by Molmil](/molmil-images/mine/6upk) | Structure of FACT_subnucleosome complex 1 | Descriptor: | DNA (79-mer), FACT complex subunit SPT16, FACT complex subunit SSRP1, ... | Authors: | Zhou, K, Tan, Y.Z, Wei, H, Liu, Y, Carragher, B, Potter, C, Luger, K. | Deposit date: | 2019-10-17 | Release date: | 2019-12-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | FACT caught in the act of manipulating the nucleosome. Nature, 577, 2020
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6UYU
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![BU of 6uyu by Molmil](/molmil-images/mine/6uyu) | Crystal structure of K45-acetylated SUMO1 in complex with phosphorylated PML-SIM | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6UYQ
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![BU of 6uyq by Molmil](/molmil-images/mine/6uyq) | Crystal structure of K45-acetylated SUMO1 in complex with PML-SIM | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6UYR
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![BU of 6uyr by Molmil](/molmil-images/mine/6uyr) | Crystal structure of K46-acetylated SUMO1 in complex with PML-SIM | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6UYY
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![BU of 6uyy by Molmil](/molmil-images/mine/6uyy) | Crystal structure of K39-acetylated SUMO1 in complex with phosphorylated DAXX | Descriptor: | Small ubiquitin-related modifier 1, phosphorylated DAXX | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6V7Q
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![BU of 6v7q by Molmil](/molmil-images/mine/6v7q) | Crystal structure of SUMO1 in complex with phosphorylated PIAS-SIM2 | Descriptor: | Protein PIAS, Small ubiquitin-related modifier 1 | Authors: | Lussier-Price, M, Wahba, H.M, Mascle, X.H, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-12-09 | Release date: | 2020-04-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins. Structure, 28, 2020
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6V7S
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![BU of 6v7s by Molmil](/molmil-images/mine/6v7s) | Crystal structure of K37-acetylated SUMO1 in complex with phosphorylated PIAS-SIM2 | Descriptor: | Protein PIAS, Small ubiquitin-related modifier 1 | Authors: | Lussier-Price, M, Wahba, H.M, Mascle, X.H, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-12-09 | Release date: | 2020-04-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins. Structure, 28, 2020
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6UYV
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![BU of 6uyv by Molmil](/molmil-images/mine/6uyv) | Crystal structure of K46-acetylated SUMO1 in complex with phosphorylated PML-SIM | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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6UYP
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![BU of 6uyp by Molmil](/molmil-images/mine/6uyp) | Crystal structure of K39-acetylated SUMO1 in complex with PML-SIM | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | Deposit date: | 2019-11-14 | Release date: | 2019-11-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.418 Å) | Cite: | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure, 28, 2020
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