3RBE
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4H5L
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4H5Q
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4H5M
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5U0P
| Cryo-EM structure of the transcriptional Mediator | Descriptor: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | Authors: | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | Deposit date: | 2016-11-26 | Release date: | 2017-03-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Mediator structure and rearrangements required for holoenzyme formation. Nature, 544, 2017
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6IC9
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5GPY
| Crystal structure of the human TFIIE complex | Descriptor: | General transcription factor IIE subunit 1, Transcription initiation factor IIE subunit beta, ZINC ION | Authors: | Obita, T, Miwa, K, Kojima, R, Ohkuma, Y, Tamura, Y, Mizuguchi, M. | Deposit date: | 2016-08-05 | Release date: | 2016-11-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution J.Mol.Biol., 428, 2016
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6CST
| Structure of human DNA polymerase kappa with DNA | Descriptor: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CHLORIDE ION, ... | Authors: | Jha, V, Ling, H. | Deposit date: | 2018-03-21 | Release date: | 2019-01-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2.0 angstrom resolution crystal structure of human pol kappa reveals a new catalytic function of N-clasp in DNA replication. Sci Rep, 8, 2018
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4OR6
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5YUY
| DNA polymerase IV - DNA ternary complex 9 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-10-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUR
| DNA polymerase IV - DNA ternary complex 1 | Descriptor: | DNA polymerase IV, DTN, SODIUM ION, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.035 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUT
| DNA polymerase IV - DNA ternary complex 3 | Descriptor: | DNA polymerase IV, DTN, MAGNESIUM ION, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-09-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUZ
| DNA polymerase IV - DNA ternary complex 11 | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res., 46, 2018
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5W2E
| HCV NS5B RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor MK-8876 | Descriptor: | 2-(4-fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide, Genome polyprotein | Authors: | Lesburg, C.A, Ummat, A. | Deposit date: | 2017-06-06 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876. ChemMedChem, 12, 2017
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5YUU
| DNA polymerase IV - DNA ternary complex 4 | Descriptor: | DNA polymerase IV, DTN1, DTN2, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUS
| DNA polymerase IV - DNA ternary complex 2 | Descriptor: | DNA polymerase IV, DTN, MAGNESIUM ION, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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5YUV
| DNA polymerase IV - DNA ternary complex 5 | Descriptor: | DNA polymerase IV, DTN1, DTN2, ... | Authors: | Kottur, J, Nair, D.T. | Deposit date: | 2017-11-23 | Release date: | 2018-10-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
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3K59
| Crystal structure of E.coli Pol II-normal DNA-dCTP ternary complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*GP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... | Authors: | Yang, W, Wang, F. | Deposit date: | 2009-10-06 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
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6IC8
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3K57
| Crystal structure of E.coli Pol II-normal DNA-dATP ternary complex | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*G*TP*AP*TP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*G)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), ... | Authors: | Yang, W, Wang, F. | Deposit date: | 2009-10-06 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
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3K58
| Crystal structure of E.coli Pol II-normal DNA-dTTP ternary complex | Descriptor: | DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*AP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), DNA polymerase II, ... | Authors: | Yang, W, Wang, F. | Deposit date: | 2009-10-06 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
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3K5L
| Crystal structure of E.coli Pol II-abasic DNA-dATP Lt(0, 3) ternary complex | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*TP*(3DR)P*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... | Authors: | Yang, W, Wang, F. | Deposit date: | 2009-10-07 | Release date: | 2010-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
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7M09
| Pre-catalytic quaternary complex of DNA Polymerase Lambda with blunt-ended DSB substrate and incoming dUMPNPP | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2021-03-10 | Release date: | 2022-03-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
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7M0D
| Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound complementary DSB substrate and incoming dUMPNPP | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2021-03-10 | Release date: | 2022-03-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
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7M0B
| Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound mismatched DSB and incoming dUMPNPP | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2021-03-10 | Release date: | 2022-03-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
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