PDB: 222415 resultsInfo pagesStatus searchChemie searchBIRD

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6DOY	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM Li+ for 120 s at 21 C Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7LV3	Crystal structure of human protein kinase G (PKG) R-C complex in inhibited state Descriptor: 1,2-ETHANEDIOL, Isoform Beta of cGMP-dependent protein kinase 1, MANGANESE (II) ION, ... Authors: Sharma, R, Lying, Q, Casteel, D, Kim, C. Deposit date: 2021-02-23 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.41 Å) Cite: An auto-inhibited state of protein kinase G and implications for selective activation. Elife, 11, 2022
2GFW	Structure of wild type E. coli FabF (KASII) Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GG7	Novel bacterial methionine aminopeptidase inhibitors Descriptor: 3-(5-AMINO-3-IMINO-3H-PYRAZOL-4-YLAZO)-BENZOIC ACID, COBALT (II) ION, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
1MSS	LARGE SCALE STRUCTURAL REARRANGEMENTS OF THE FRONT LOOPS IN MONOMERISED TRIOSEPHOSPHATE ISOMERASE, AS DEDUCED FROM THE COMPARISON OF THE STRUCTURAL PROPERTIES OF MONOTIM AND ITS POINT MUTATION VARIANT MONOSS Descriptor: TRIOSEPHOSPHATE ISOMERASE Authors: Radha Kishan, K.V, Wierenga, R.K. Deposit date: 1994-07-27 Release date: 1994-09-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8. Structure, 3, 1995
2FY5	Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis Descriptor: Choline O-acetyltransferase, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE Authors: Kim, A.R, Rylett, R.J, Shilton, B.H. Deposit date: 2006-02-07 Release date: 2006-12-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Substrate binding and catalytic mechanism of human choline acetyltransferase. Biochemistry, 45, 2006
1MXX	crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) Descriptor: GLUTAMATE RECEPTOR 2, ZINC ION Authors: Jin, R, Gouaux, E. Deposit date: 2002-10-03 Release date: 2003-06-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Probing the Function, Conformational Plasticity, and Dimer-Dimer Contacts of the GluR2 Ligand-Binding Core: Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal Biochemistry, 42, 2003
7ROV	KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903 Descriptor: Cyclic peptide MP-9903, GLYCEROL, Isoform 2B of GTPase KRas, ... Authors: Orth, P. Deposit date: 2021-08-02 Release date: 2021-09-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling. Chem Sci, 12, 2021
1MX8	Two homologous rat cellular retinol-binding proteins differ in local structure and flexibility Descriptor: CELLULAR RETINOL-BINDING PROTEIN I, HOLO, RETINOL Authors: Lu, J, Cistola, D.P, Li, E. Deposit date: 2002-10-01 Release date: 2003-07-29 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility. J.Mol.Biol., 330, 2003
2G2U	Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex Descriptor: Beta-lactamase SHV-1, Beta-lactamase inhibitory protein Authors: Reynolds, K.A, Thomson, J.M, Corbett, K.D, Bethel, C.R, Berger, J.M, Kirsch, J.F, Bonomo, R.A, Handel, T.M. Deposit date: 2006-02-16 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural and Computational Characterization of the SHV-1 beta-Lactamase-beta-Lactamase Inhibitor Protein Interface. J.Biol.Chem., 281, 2006
1N20	(+)-Bornyl Diphosphate Synthase: Complex with Mg and 3-aza-2,3-dihydrogeranyl diphosphate Descriptor: (+)-bornyl diphosphate synthase, 2-[METHYL-(4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, MAGNESIUM ION Authors: Whittington, D.A, Wise, M.L, Urbansky, M, Coates, R.M, Croteau, R.B, Christianson, D.W. Deposit date: 2002-10-21 Release date: 2002-11-27 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Bornyl Diphosphate Synthase: Structure and Strategy for Carbocation Manipulation by a Terpenoid Cyclase Proc.Natl.Acad.Sci.USA, 99, 2002
6DK3	HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2 Descriptor: Serine hydroxymethyltransferase, mitochondrial, UNKNOWN ATOM OR ION Authors: Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) Deposit date: 2018-05-28 Release date: 2018-06-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.04 Å) Cite: HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2 to be published
2GDN	Crystal structure of the Mycobacterium tuberculosis beta-lactamase Descriptor: Beta-lactamase Authors: Wang, F, Cassidy, C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) Deposit date: 2006-03-16 Release date: 2006-04-18 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal Structure and Activity Studies of the Mycobacterium tuberculosis {beta}-Lactamase Reveal Its Critical Role in Resistance to {beta}-Lactam Antibiotics. Antimicrob.Agents Chemother., 50, 2006
2G78	Crystal Structure of the R132K:Y134F Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans-Retinoic Acid at 1.70 Angstroms Resolution Descriptor: Cellular retinoic acid-binding protein 2, RETINOIC ACID, SODIUM ION Authors: Vaezeslami, S, Geiger, J.H. Deposit date: 2006-02-27 Release date: 2007-04-17 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic. J.Am.Chem.Soc., 129, 2007
7LVA	Solution structure of the HIV-1 PBS-segment Descriptor: RNA (103-MER) Authors: Heng, X, Song, Z. Deposit date: 2021-02-24 Release date: 2021-03-17 Last modified: 2024-05-15 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: The three-way junction structure of the HIV-1 PBS-segment binds host enzyme important for viral infectivity. Nucleic Acids Res., 49, 2021
2GFY	Structure of E. coli FabF(K335A) mutant with covalently linked dodecanoic acid Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, LAURIC ACID Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
7RCO	Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab Descriptor: 4A11.V2 Fab Heavy Chain, 4A11.V2 Fab Light Chain, Transforming growth factor beta-2 Authors: Yin, J, Lupardus, P.J, Sudhamsu, J. Deposit date: 2021-07-07 Release date: 2021-09-29 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Dramatic activation of an antibody by a single amino acid change in framework. Sci Rep, 11, 2021
6DOG	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 600 s at 21 C Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.285 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DOU	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 5 mM Mg2+ and 200 mM Rb+ for 120 s at 21 C Descriptor: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.487 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
1MWN	Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12 Descriptor: CALCIUM ION, F-actin capping protein alpha-1 subunit, S-100 protein, ... Authors: Inman, K.G, Yang, R, Rustandi, R.R, Miller, K.E, Baldisseri, D.M, Weber, D.J. Deposit date: 2002-09-30 Release date: 2002-12-18 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12 J.Mol.Biol., 324, 2002
6DPN	Crystal Structure of Bacillus Halodurans Ribonuclease H1 E188A in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 200 s at 21 C Descriptor: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), 5'-R(P*CP*G)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.493 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
2GA0	Variable Small Protein 1 of Borrelia turicatae (VspA or Vsp1) Descriptor: NICKEL (II) ION, surface protein VspA Authors: Lawson, C.L, Yung, B.H, Barbour, A.G, Zuckert, W.R. Deposit date: 2006-03-07 Release date: 2006-06-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae. J.Bacteriol., 188, 2006
2GB4	Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, Thiopurine S-methyltransferase Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2006-03-09 Release date: 2006-09-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution To be published
1N22	(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene Descriptor: (+)-bornyl diphosphate synthase, (1R)-DIMETHYL-(4-METHYL-CYCLOHEX-3-ENYL)-AMINE, MAGNESIUM ION, ... Authors: Whittington, D.A, Wise, M.L, Urbansky, M, Coates, R.M, Croteau, R.B, Christianson, D.W. Deposit date: 2002-10-21 Release date: 2002-11-27 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase Proc.Natl.Acad.Sci.USA, 99, 2002

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