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5VA3
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Cryo-EM structure of the human ether-a-go-go related K+ channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W, MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5VA2
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BU of 5va2 by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W, MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
2LE7
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BU of 2le7 by Molmil
Solution nmr structure of the S4S5 linker of herg potassium channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Ng, C.A, Kuchel, P.W, Vandenberg, J.I.
Deposit date:2011-06-13
Release date:2012-04-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating
Plos One, 7, 2012
3PJZ
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BU of 3pjz by Molmil
Crystal Structure of the Potassium Transporter TrkH from Vibrio parahaemolyticus
Descriptor: POTASSIUM ION, Potassium uptake protein TrkH
Authors:Cao, Y, Jin, X, Huang, H, Levin, E.J, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2010-11-10
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.506 Å)
Cite:Crystal structure of a potassium ion transporter, TrkH.
Nature, 471, 2011
2L0W
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BU of 2l0w by Molmil
Solution NMR structure of the N-terminal PAS domain of HERG potassium channel
Descriptor: Potassium voltage-gated channel, subfamily H (Eag-related), member 2, ...
Authors:Ng, C.A, Hunter, M.J, Mobli, M, King, G.F, Kuchel, P.W, Vandenberg, J.I.
Deposit date:2010-07-19
Release date:2011-01-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The N-Terminal Tail of hERG Contains an Amphipathic alpha-Helix That Regulates Channel Deactivation
PLoS ONE, 6, 2011
1S6X
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BU of 1s6x by Molmil
Solution structure of VSTx
Descriptor: KvAP CHANNEL
Authors:Jung, H.J, Eu, Y.J, Kim, J.I.
Deposit date:2004-01-28
Release date:2005-03-22
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel.
Biochemistry, 44, 2005
4V0C
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BU of 4v0c by Molmil
Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin
Descriptor: CALCIUM ION, CALMODULIN, POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1, ...
Authors:Sachyani, D, Hirsch, J.A.
Deposit date:2014-09-14
Release date:2014-11-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-Terminal Domain in Complex with Calmodulin.
Structure, 22, 2014
5V02
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BU of 5v02 by Molmil
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Descriptor: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, Calmodulin-1, ...
Authors:Liu, S.
Deposit date:2017-02-28
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
6CPV
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BU of 6cpv by Molmil
MicroED structure of NaK ion channel reveals a process of Na+ partition into the selectivity filter
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein, SODIUM ION
Authors:Liu, S, Gonen, T.
Deposit date:2018-03-14
Release date:2018-09-12
Last modified:2023-10-04
Method:ELECTRON CRYSTALLOGRAPHY (2.5 Å)
Cite:MicroED structure of the NaK ion channel reveals a Na+partition process into the selectivity filter.
Commun Biol, 1, 2018
5KUK
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BU of 5kuk by Molmil
Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant
Descriptor: ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION
Authors:Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G.
Deposit date:2016-07-13
Release date:2016-08-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.
J.Gen.Physiol., 148, 2016
8A7X
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BU of 8a7x by Molmil
NaK C-DI F92A mutant soaked in Cs+
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CESIUM ION, POTASSIUM ION, ...
Authors:Minniberger, S, Plested, A.J.R.
Deposit date:2022-06-21
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023
3E8B
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BU of 3e8b by Molmil
Crystal Structure of the the open NaK channel- Rb+ complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein, RUBIDIUM ION
Authors:Jiang, Y, Alam, A.
Deposit date:2008-08-19
Release date:2008-12-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural analysis of ion selectivity in the NaK channel
Nat.Struct.Mol.Biol., 16, 2009
3E89
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BU of 3e89 by Molmil
Crystal Structure of the the open NaK channel-low Na+ complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CESIUM ION, Potassium channel protein, ...
Authors:Jiang, Y, Alam, A.
Deposit date:2008-08-19
Release date:2008-12-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of ion selectivity in the NaK channel
Nat.Struct.Mol.Biol., 16, 2009
3E8G
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BU of 3e8g by Molmil
Crystal Structure of the the open NaK channel-Na+/Ca2+ complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CESIUM ION, ...
Authors:Jiang, Y, Alam, A.
Deposit date:2008-08-19
Release date:2008-12-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of ion selectivity in the NaK channel
Nat.Struct.Mol.Biol., 16, 2009
5VRE
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BU of 5vre by Molmil
Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from Chamaesiphon Minutus
Descriptor: Putative integral membrane protein
Authors:Lee, C, Guo, J, Jiang, Y.
Deposit date:2017-05-10
Release date:2017-07-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.
Nature, 547, 2017
4WFH
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BU of 4wfh by Molmil
Human TRAAK K+ channel in a Tl+ bound nonconductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFG
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BU of 4wfg by Molmil
Human TRAAK K+ channel in a Tl+ bound conductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
7PQU
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BU of 7pqu by Molmil
Ligand-bound human Kv3.1 cryo-EM structure (Lu AG00563)
Descriptor: 1-(4-methylphenyl)sulfonyl-N-(1,3-oxazol-2-ylmethyl)pyrrole-3-carboxamide, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1
Authors:Botte, M, Huber, S, Bucher, D, Klint, J.K, Rodriguez, D, Tagmose, L, Chami, M, Cheng, R, Hennig, M, Abdul Rhaman, W.
Deposit date:2021-09-20
Release date:2022-08-17
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Pnas Nexus, 1, 2022
6XIS
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BU of 6xis by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in apo form
Descriptor: G protein-activated inward rectifier potassium channel 2
Authors:Niu, Y, Tao, X, MacKinnon, R.
Deposit date:2020-06-21
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
7VNQ
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BU of 7vnq by Molmil
Structure of human KCNQ4-ML213 complex in nanodisc
Descriptor: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ...
Authors:Xu, F, Zheng, Y.
Deposit date:2021-10-11
Release date:2021-12-01
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
7VNR
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BU of 7vnr by Molmil
Structure of human KCNQ4-ML213 complex in digitonin
Descriptor: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ...
Authors:Xu, F, Zheng, Y.
Deposit date:2021-10-11
Release date:2021-12-01
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
7VNP
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BU of 7vnp by Molmil
Structure of human KCNQ4-ML213 complex with PIP2
Descriptor: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ...
Authors:Xu, F, Zheng, Y.
Deposit date:2021-10-11
Release date:2021-12-01
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
7OOR
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BU of 7oor by Molmil
NaK C-DI mutant with Na+ and K+
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:Minniberger, S, Plested, A.J.R.
Deposit date:2021-05-28
Release date:2022-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023
7OPH
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BU of 7oph by Molmil
NaK S-DI mutant with Na+ and K+
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:Minniberger, S, Plested, A.J.R.
Deposit date:2021-05-31
Release date:2022-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023
7OOU
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BU of 7oou by Molmil
NaK C-DI mutant with Li+ and K+
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ...
Authors:Minniberger, S, Plested, A.J.R.
Deposit date:2021-05-28
Release date:2022-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023

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數據於2024-07-24公開中

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