5V02

A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA

Summary for 5V02

• Entry DOI: 10.2210/pdb5v02/pdb
• Descriptor: Small conductance calcium-activated potassium channel protein 2, Calmodulin-1, SULFATE ION, ... (7 entities in total)
• Functional Keywords: calcium-activated ion channels, activator, calmodulin, transport protein-metal binding protein complex, transport protein/metal binding protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Multi-pass membrane protein: Q9H2S1; Cytoplasm, cytoskeleton, spindle : P0DP23
• Total number of polymer chains: 2
• Total formula weight: 29694.51

Authors

Liu, S. (deposition date: 2017-02-28, release date: 2018-03-07, Last modification date: 2023-10-04)

• Primary citation: Cho, L.T.,Alexandrou, A.J.,Torella, R.,Knafels, J.,Hobbs, J.,Taylor, T.,Loucif, A.,Konopacka, A.,Bell, S.,Stevens, E.B.,Pandit, J.,Horst, R.,Withka, J.M.,Pryde, D.C.,Liu, S.,Young, G.T.; An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.; Structure, 26:533-544.e3, 2018; PubMed: 29576321; DOI: 10.1016/j.str.2018.02.017

Experimental method

X-RAY DIFFRACTION (1.78 Å)