3GCQ
 
 | | Human P38 MAP kinase in complex with RL45 | | Descriptor: | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | Authors: | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | Deposit date: | 2009-02-22 | | Release date: | 2009-06-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
J.Am.Chem.Soc., 131, 2009
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3BTS
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8UIC
 | | Structure of the Drosophila IntS11-CG7044(dBRAT1) complex | | Descriptor: | FI02071p, Integrator complex subunit 11, ZINC ION | | Authors: | Lin, M, Tong, L. | | Deposit date: | 2023-10-10 | | Release date: | 2024-08-21 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
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4MD8
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4MD7
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8OTZ
 | | 48-nm repeat of the native axonemal doublet microtubule from bovine sperm | | Descriptor: | ATP6V1F neighbor, CFAP97 domain containing 1, Chromosome 13 C20orf85 homolog, ... | | Authors: | Leung, M.R, Zeng, J, Zhang, R, Zeev-Ben-Mordehai, T. | | Deposit date: | 2023-04-21 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural specializations of the sperm tail.
Cell, 186, 2023
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8T2S
 | | Structure of a group II intron ribonucleoprotein in the pre-branching (pre-1F) state | | Descriptor: | AMMONIUM ION, CALCIUM ION, Group II intron reverse transcriptase/maturase, ... | | Authors: | Xu, L, Liu, T, Chung, K, Pyle, A.M. | | Deposit date: | 2023-06-06 | | Release date: | 2023-11-22 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into intron catalysis and dynamics during splicing.
Nature, 624, 2023
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6R3V
 | | Crystal Structure of RhoA-GDP-Pi in Complex with RhoGAP | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Jin, Y. | | Deposit date: | 2019-03-21 | | Release date: | 2019-05-08 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | A GAP-GTPase-GDP-PiIntermediate Crystal Structure Analyzed by DFT Shows GTP Hydrolysis Involves Serial Proton Transfers.
Chemistry, 25, 2019
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2ZU6
 | | crystal structure of the eIF4A-PDCD4 complex | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | | Authors: | Cho, Y, Chang, J.H, Sohn, S.Y. | | Deposit date: | 2008-10-13 | | Release date: | 2009-02-24 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the eIF4A-PDCD4 complex
Proc.Natl.Acad.Sci.Usa, 106, 2009
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3MVL
 | | P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K | | Descriptor: | 4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 | | Authors: | Sack, J.S. | | Deposit date: | 2010-05-04 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38 Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
J.Med.Chem., 53, 2010
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4IQJ
 | | Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome | | Descriptor: | DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*GP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*A)-3'), DNA (5'-D(P*CP*GP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DOC))-3'), ... | | Authors: | Liu, B, Lin, J, Steitz, T. | | Deposit date: | 2013-01-11 | | Release date: | 2013-03-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome
Structure, 21, 2013
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3MVM
 | | P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V | | Descriptor: | 4-{[5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 | | Authors: | Sack, J.S. | | Deposit date: | 2010-05-04 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38? Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
J.Med.Chem., 53, 2010
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6WWA
 | | Crystal structure of human SHLD2-SHLD3-REV7 complex | | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 2,Shieldin complex subunit 3 chimera | | Authors: | Xie, W, Patel, D.J. | | Deposit date: | 2020-05-08 | | Release date: | 2021-03-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6WW9
 | | Crystal structure of human REV7(R124A)-SHLD3(35-58) complex | | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 3 | | Authors: | Xie, W, Patel, D.J. | | Deposit date: | 2020-05-08 | | Release date: | 2021-03-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8C03
 | | Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in outward-facing conformation | | Descriptor: | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, Solute carrier family 40 member 1 | | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | | Deposit date: | 2022-12-15 | | Release date: | 2023-03-22 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport.
Elife, 12, 2023
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8BZY
 | | Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation | | Descriptor: | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, DIUNDECYL PHOSPHATIDYL CHOLINE, Solute carrier family 40 member 1, ... | | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | | Deposit date: | 2022-12-15 | | Release date: | 2023-03-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport.
Elife, 12, 2023
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8C02
 | | Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation | | Descriptor: | Solute carrier family 40 member 1, Sybody3 | | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | | Deposit date: | 2022-12-15 | | Release date: | 2023-03-22 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (4.09 Å) | | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport.
Elife, 12, 2023
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7XUZ
 | | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | | Descriptor: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | | Authors: | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | | Deposit date: | 2022-05-20 | | Release date: | 2023-11-29 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (3.591 Å) | | Cite: | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
Nucleic Acids Res., 52, 2024
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8T2R
 | | Structure of a group II intron ribonucleoprotein in the pre-ligation (pre-2F) state | | Descriptor: | 5'exon, AMMONIUM ION, CALCIUM ION, ... | | Authors: | Xu, L, Liu, T, Chung, K, Pyle, A.M. | | Deposit date: | 2023-06-06 | | Release date: | 2023-11-22 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into intron catalysis and dynamics during splicing.
Nature, 624, 2023
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6SYF
 | | Human Ubc9 with covalent isopeptide ligand | | Descriptor: | ACE-ILE-LYS-GLN-GLU, ACE-LEU-ARG-LEU-ARG-GLY-CYS, SUMO-conjugating enzyme UBC9 | | Authors: | Hofmann, R, Akimoto, G, Wucherpfennig, T.G, Zeymer, C, Bode, J.W. | | Deposit date: | 2019-09-27 | | Release date: | 2020-08-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins.
Nat.Chem., 12, 2020
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5FA5
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6RLW
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3TG4
 | | Structure of SMYD2 in complex with SAM | | Descriptor: | GLYCEROL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... | | Authors: | Zhao, K, Wang, L. | | Deposit date: | 2011-08-17 | | Release date: | 2011-08-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
J.Biol.Chem., 2011
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5W44
 | | Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7a (SRI-29770) | | Descriptor: | 2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide, MAGNESIUM ION, MANGANESE (II) ION, ... | | Authors: | Kumar, G, White, S.W. | | Deposit date: | 2017-06-09 | | Release date: | 2018-01-10 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
Sci Rep, 7, 2017
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2NPI
 | | Clp1-ATP-Pcf11 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein CLP1, ... | | Authors: | Noble, C.G, Beuth, B, Taylor, I.A. | | Deposit date: | 2006-10-27 | | Release date: | 2006-12-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor
Nucleic Acids Res., 35, 2007
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