5W44
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7a (SRI-29770)
Summary for 5W44
| Entry DOI | 10.2210/pdb5w44/pdb |
| Related | 5W3I |
| Descriptor | Polymerase acidic protein, MANGANESE (II) ION, 2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide, ... (6 entities in total) |
| Functional Keywords | nuclease, transcription, cap-snatching, virus, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Influenza A virus |
| Total number of polymer chains | 1 |
| Total formula weight | 21651.65 |
| Authors | Kumar, G.,White, S.W. (deposition date: 2017-06-09, release date: 2018-01-10, Last modification date: 2023-10-04) |
| Primary citation | Beylkin, D.,Kumar, G.,Zhou, W.,Park, J.,Jeevan, T.,Lagisetti, C.,Harfoot, R.,Webby, R.J.,White, S.W.,Webb, T.R. Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7:17139-17139, 2017 Cited by PubMed: 29215062DOI: 10.1038/s41598-017-17419-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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