5W44
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7a (SRI-29770)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polymerase acidic protein | polymer | 178 | 21048.1 | 1 | UniProt (C3W5S0) | Influenza A virus | RNA-directed RNA polymerase subunit P2 |
| 2 | B (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 3 | C (A) | 2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide | non-polymer | 501.4 | 1 | Chemie (GY6) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F (A) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A: 1 - 178 (UniProt: C3W5S0)
| PDB | External Database | Details |
|---|---|---|
| - | Phe 51 | deletion |
| - | His 52 | deletion |
| - | Phe 53 | deletion |
| - | Ile 54 | deletion |
| - | Asp 55 | deletion |
| - | Glu 56 | deletion |
| - | Arg 57 | deletion |
| - | Gly 58 | deletion |
| - | Glu 59 | deletion |
| - | Ser 60 | deletion |
| - | Ile 61 | deletion |
| - | Ile 62 | deletion |
| - | Val 63 | deletion |
| - | Glu 64 | deletion |
| - | Ser 65 | deletion |
| - | Gly 66 | deletion |
| - | Asp 67 | deletion |
| - | Pro 68 | deletion |
| - | Asn 69 | deletion |
| Gly 51 | Ala 70 | linker |
| Gly 52 | Leu 71 | linker |
| Ser 53 | Leu 72 | linker |
| Ala 178 | Gly 197 | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21048.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 603.6 | |
| All* | Total formula weight | 21651.6 |
