PDB: 8717 resultsInfo pagesStatus searchChemie searchBIRD

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4H10	Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic Helix-Loop-Helix domains with E-box DNA Descriptor: Aryl hydrocarbon receptor nuclear translocator-like protein 1, Circadian locomoter output cycles protein kaput, E-box DNA antisense strand, ... Authors: Wang, Z, Su, X.-D. Deposit date: 2012-09-10 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.402 Å) Cite: Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA. Cell Res., 23, 2013
4EOL	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor RO3306 Descriptor: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... Authors: Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. Deposit date: 2012-04-14 Release date: 2013-02-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
4EOQ	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... Authors: Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. Deposit date: 2012-04-14 Release date: 2013-02-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
7ZTD	Non-muscle F-actin decorated with non-muscle tropomyosin 3.2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 3.2, actin, ... Authors: Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. Deposit date: 2022-05-09 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms. Cell Rep, 42, 2023
7ZTC	Non-muscle F-actin decorated with non-muscle tropomyosin 1.6 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 1.6, actin, ... Authors: Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. Deposit date: 2022-05-09 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms. Cell Rep, 42, 2023
3A01	Crystal structure of Aristaless and Clawless homeodomains bound to DNA Descriptor: 5'-D(*CP*CP*GP*CP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*GP*CP*GP*G)-3', Homeobox protein aristaless, ... Authors: Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2009-02-28 Release date: 2010-03-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
3A02	Crystal structure of Aristaless homeodomain Descriptor: CADMIUM ION, CHLORIDE ION, Homeobox protein aristaless Authors: Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2009-02-28 Release date: 2010-03-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
1R4M	APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex Descriptor: Ubiquitin-like protein NEDD8, ZINC ION, amyloid beta precursor protein-binding protein 1, ... Authors: Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A. Deposit date: 2003-10-07 Release date: 2003-12-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol.Cell, 12, 2003
2XG8	Structural basis of gene regulation by protein PII: The crystal complex of PII and PipX from Synechococcus elongatus PCC 7942 Descriptor: NITROGEN REGULATORY PROTEIN P-II, PIPX Authors: Llacer, J.L, Rubio, V. Deposit date: 2010-06-01 Release date: 2010-08-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii. Proc.Natl.Acad.Sci.USA, 107, 2010
1F43	SOLUTION STRUCTURE OF THE MATA1 HOMEODOMAIN Descriptor: MATING-TYPE PROTEIN A-1 Authors: Anderson, J.S, Forman, M, Modleski, S, Dahlquist, F.W, Baxter, S.M. Deposit date: 2000-06-07 Release date: 2000-07-26 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Cooperative ordering in homeodomain-DNA recognition: solution structure and dynamics of the MATa1 homeodomain. Biochemistry, 39, 2000
7ZMW	14-3-3s binding to non-natural peptide 2c Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 1 Authors: Somsen, B.A, Craenmehr, F.W.B, Ottmann, C. Deposit date: 2022-04-19 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022
7ZMU	14-3-3s binding to non-natural peptide 2d Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 2 Authors: Somsen, B.A, Craenmehr, F.W.B, Ottmann, C. Deposit date: 2022-04-19 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022
1K6I	Crystal structure of Nmra, a negative transcriptional regulator (Trigonal form) Descriptor: CHLORIDE ION, NmrA Authors: Stammers, D.K, Ren, J, Leslie, K, Nichols, C.E, Lamb, H.K, Cocklin, S, Dodds, A, Hawkins, A.R. Deposit date: 2001-10-16 Release date: 2001-12-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. EMBO J., 20, 2001
1R4N	APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ubiquitin-like protein NEDD8, ZINC ION, ... Authors: Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A. Deposit date: 2003-10-07 Release date: 2003-12-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol.Cell, 12, 2003
1K6X	Crystal structure of Nmra, a negative transcriptional regulator in complex with NAD at 1.5 A resolution (Trigonal form) Descriptor: CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NmrA Authors: Stammers, D.K, Ren, J, Leslie, K, Nichols, C.E, Lamb, H.K, Cocklin, S, Dodds, A, Hawkins, A.R. Deposit date: 2001-10-17 Release date: 2002-02-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. EMBO J., 20, 2002
1K6J	Crystal structure of Nmra, a negative transcriptional regulator (Monoclinic form) Descriptor: CHLORIDE ION, NmrA Authors: Stammers, D.K, Ren, J, Leslie, K, Nichols, C.E, Lamb, H.K, Cocklin, S, Dodds, A, Hawkins, A.R. Deposit date: 2001-10-16 Release date: 2002-02-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. EMBO J., 20, 2001
3A03	Crystal structure of Hox11L1 homeodomain Descriptor: SODIUM ION, SULFATE ION, T-cell leukemia homeobox protein 2 Authors: Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2009-02-28 Release date: 2010-03-09 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
1GNC	STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN Descriptor: GRANULOCYTE COLONY-STIMULATING FACTOR Authors: Zink, T.W, Ross, A, Rudolph, R, Holak, T.A. Deposit date: 1994-03-08 Release date: 1994-07-31 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein. Biochemistry, 33, 1994
2PG1	Structural analysis of a cytoplasmic dynein Light Chain-Intermediate Chain complex Descriptor: Cytoplasmic dynein 1 intermediate chain 2, Dynein light chain 1, cytoplasmic, ... Authors: Williams, J.C, Hendrickson, W.A. Deposit date: 2007-04-06 Release date: 2007-06-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex Proc.Natl.Acad.Sci.Usa, 104, 2007
3JC5	Structure of the eukaryotic replicative CMG helicase and pumpjack motion Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... Authors: Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. Deposit date: 2015-11-24 Release date: 2016-02-10 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
3JC6	Structure of the eukaryotic replicative CMG helicase and pumpjack motion Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... Authors: Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. Deposit date: 2015-11-24 Release date: 2016-02-10 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
2F2C	X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol Descriptor: (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Cell division protein kinase 6, Cyclin homolog, ... Authors: Schulze-Gahmen, U, Lu, H. Deposit date: 2005-11-16 Release date: 2006-06-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. J.Med.Chem., 49, 2006
2EUF	X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991 Descriptor: 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ACETATE ION, CALCIUM ION, ... Authors: Schulze-Gahmen, U, Lu, H. Deposit date: 2005-10-28 Release date: 2006-07-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3 Å) Cite: Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. J.Med.Chem., 49, 2006
3BBF	Crystal structure of the NM23-H2 transcription factor complex with GDP Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Weichsel, A, Montfort, W.R. Deposit date: 2007-11-09 Release date: 2008-09-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1. Mol.Cancer Ther., 8, 2009
3BBB	Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG) Descriptor: DNA (5'-D(*AP*G)-3'), Nucleoside diphosphate kinase B Authors: Weichsel, A, Montfort, W.R. Deposit date: 2007-11-09 Release date: 2008-09-23 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.3 Å) Cite: NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1. Mol.Cancer Ther., 8, 2009

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