2FUG
 
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2FZS
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2FZJ
 | | New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives | | Descriptor: | 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Cody, V, Pace, J, Chisum, K, Rosowsky, A. | | Deposit date: | 2006-02-09 | | Release date: | 2006-12-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
Proteins, 65, 2006
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2FVN
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2FNC
 | | Thermotoga maritima maltotriose binding protein bound with maltotriose. | | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltose ABC transporter, periplasmic maltose-binding protein | | Authors: | Cuneo, M.J, Changela, A. | | Deposit date: | 2006-01-10 | | Release date: | 2007-01-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The
crystal structure of redundant maltotriose binding proteins from the
thermophile Thermotoga maritima
To be Published
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2HEO
 | | General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers. | | Descriptor: | 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Z-DNA binding protein 1 | | Authors: | Magis, C, Gasparini, S, Charbonnier, J.B, Stura, E, Le Du, M.H, Menez, A, Cuniasse, P. | | Deposit date: | 2006-06-21 | | Release date: | 2006-11-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers.
J.Am.Chem.Soc., 128, 2006
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2H7T
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2GPL
 | | TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors | | Descriptor: | BENZYL [12-(2-AMINO-2-OXOETHYL)-4-NITRO-10,13-DIOXO-15-[(PROPYLAMINO)CARBONYL]-2-OXA-11,14-DIAZATRICYCLO[15 .2.2.1~3,7~]DOCOSA-1(19),3(22),4,6,17,20-HEXAEN-9-YL]CARBAMATE, Proteasome component C1, Proteasome component C11, ... | | Authors: | Groll, M, Goetz, M, Kaiser, M, Weyher, E, Moroder, M. | | Deposit date: | 2006-04-18 | | Release date: | 2006-07-11 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome.
Chem.Biol., 13, 2006
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2GT6
 | | Solution structure of Human Cu(I) Sco1 | | Descriptor: | COPPER (I) ION, SCO1 protein homolog, mitochondrial | | Authors: | Banci, L, Bertini, I, Calderone, V, Ciofi-Baffoni, S, Mangani, S, Palumaa, P, Martinelli, M, Wang, S, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2006-04-27 | | Release date: | 2006-06-06 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A hint for the function of human Sco1 from different structures.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GXA
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2H35
 | | Solution structure of Human normal adult hemoglobin | | Descriptor: | Hemoglobin alpha subunit, Hemoglobin beta subunit, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Fan, J.S, Yang, D. | | Deposit date: | 2006-05-22 | | Release date: | 2006-11-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A new strategy for structure determination of large proteins in solution without deuteration
Nat.Methods, 3, 2006
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1D3B
 | | CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION | | Descriptor: | CITRIC ACID, GLYCEROL, PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEIN B), ... | | Authors: | Kambach, C, Walke, S, Avis, J.M, De La Fortelle, E, Li, J, Nagai, K. | | Deposit date: | 1998-12-22 | | Release date: | 1999-12-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
Cell(Cambridge,Mass.), 96, 1999
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2HC7
 | | 2'-selenium-T A-DNA [G(TSe)GTACAC] | | Descriptor: | 5'-D(*GP*(2ST)P*GP*TP*AP*CP*AP*C)-3' | | Authors: | Jiang, J, Sheng, J, Huang, Z. | | Deposit date: | 2006-06-15 | | Release date: | 2006-07-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal Structure of 2'-Selenium modified T A-DNA G(TSe)GTACAC
TO BE PUBLISHED
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2H1L
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2HRQ
 | | Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD) | | Descriptor: | (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, ... | | Authors: | Fleming, C.D, Redinbo, M.R. | | Deposit date: | 2006-07-20 | | Release date: | 2007-05-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
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2HIL
 | | Structure of the Neisseria gonorrhoeae Type IV pilus filament from x-ray crystallography and electron cryomicroscopy | | Descriptor: | Fimbrial protein, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, alpha-D-galactopyranose-(1-3)-2,4-bisacetamido-2,4-dideoxy-beta-D-glucopyranose | | Authors: | Craig, L, Volkmann, N, Egelman, E.H, Tainer, J.A. | | Deposit date: | 2006-06-29 | | Release date: | 2006-09-12 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (12.5 Å) | | Cite: | Type IV Pilus Structure by Cryo-Electron Microscopy and Crystallography: Implications for Pilus Assembly and Functions.
Mol.Cell, 23, 2006
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2HNB
 | | Solution Structure of a bacterial holo-flavodoxin | | Descriptor: | Protein mioC | | Authors: | Hu, Y, Jin, C. | | Deposit date: | 2006-07-12 | | Release date: | 2006-09-19 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both Apo- and Holo-forms: implications for cofactor binding and electron transfer
J.Biol.Chem., 281, 2006
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2HLN
 | | L-asparaginase from Erwinia carotovora in complex with glutamic acid | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLUTAMIC ACID, L-asparaginase | | Authors: | Kravchenko, O.V, Kislitsin, Y.A, Popov, A.N, Nikonov, S.V, Kuranova, I.P. | | Deposit date: | 2006-07-08 | | Release date: | 2007-07-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Three-dimensional structures of L-asparaginase from Erwinia carotovora complexed with aspartate and glutamate.
Acta Crystallogr.,Sect.D, 64, 2008
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2HLZ
 | | Crystal Structure of human ketohexokinase | | Descriptor: | Ketohexokinase, UNKNOWN ATOM OR ION | | Authors: | Rabeh, W.M, Tempel, W, Nedyalkova, L, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-07-10 | | Release date: | 2006-08-08 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structure of human ketohexokinase (CASP Target)
To be Published
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2GBV
 | | C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase | | Descriptor: | COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION | | Authors: | Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M. | | Deposit date: | 2006-03-11 | | Release date: | 2007-01-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase
J.Mol.Biol., 365, 2007
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2GSM
 | | Catalytic Core (Subunits I and II) of Cytochrome c oxidase from Rhodobacter sphaeroides | | Descriptor: | CADMIUM ION, CALCIUM ION, COPPER (II) ION, ... | | Authors: | Qin, L, Hiser, C, Mulichak, A, Garavito, R.M, Ferguson-Miller, S. | | Deposit date: | 2006-04-26 | | Release date: | 2006-10-10 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GWE
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2H16
 | | Structure of human ADP-ribosylation factor-like 5 (ARL5) | | Descriptor: | ADP-ribosylation factor-like protein 5A, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION | | Authors: | Rabeh, W.M, Tempel, W, Yaniw, D, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-05-16 | | Release date: | 2006-06-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of human ADP-ribosylation factor-like 5 (ARL5)
To be Published
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2HRA
 | | Crystal structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA aminoacylation and nuclear export cofactor Arc1p reveal a novel function for an old fold | | Descriptor: | Glutamyl-tRNA synthetase, cytoplasmic, IODIDE ION | | Authors: | Simader, H, Hothorn, M, Suck, D. | | Deposit date: | 2006-07-20 | | Release date: | 2006-09-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2HRF
 | | Solution Structure of Cu(I) P174L HSco1 | | Descriptor: | COPPER (I) ION, SCO1 protein homolog, mitochondrial | | Authors: | Banci, L, Bertini, I, Ciofi-Baffoni, S, Leontari, I, Martinelli, M, Palumaa, P, Sillard, R, Wang, S, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2006-07-20 | | Release date: | 2007-01-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Human Sco1 functional studies and pathological implications of the P174L mutant.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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