2FZJ

New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives

Summary for 2FZJ

Entry DOI	10.2210/pdb2fzj/pdb
Related	1u70
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE, ... (4 entities in total)
Functional Keywords	dihydrofolate reductase, trimethoprim derivatives, ring stacking interactions, oxidoreductase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	22619.67
Authors	Cody, V.,Pace, J.,Chisum, K.,Rosowsky, A. (deposition date: 2006-02-09, release date: 2006-12-26, Last modification date: 2023-08-30)
Primary citation	Cody, V.,Pace, J.,Chisum, K.,Rosowsky, A. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins, 65:959-969, 2006 Cited by PubMed: 17019704 DOI: 10.1002/prot.21131 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation